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Table 2 Correlations of YAP1 protein expression and clinical and molecular parameters of the randomised cohort (n=500)

From: Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response

  All patients, n= 500   ER+patients, n=324  
  YAP1 intensity, n=324   YAP1 intensity, n=213  
  Absent Weak Intermediate Strong p-value Absent Weak Intermediate Strong p-value
  n (%) n (%) n (%) n (%)   n (%) n (%) n (%) n (%)  
Variable 28 (9) 130 (40) 128 (39) 38 (12)   21 (10) 95 (45) 79 (37) 18 (8)  
NHG           
I 0 10 (8) 11 (9) 5 (13)   0 10 (11) 11 (14) 5 (28)  
II 13 (48) 55 (44) 56 (45) 10 (27)   12 (57) 48 (50) 51 (65) 9 (50)  
III 14 (52) 60 (48) 57 (46) 22 (60) 0.932a 9 (43) 37 (39) 16 (21) 4 (22) 0.001a
Lymph node status           
Negative 7 (25) 35 (27) 34 (27) 15 (41)   5 (24) 25 (26) 19 (24) 5 (29)  
Positive 21 (75) 94 (73) 94 (73) 22 (59) 0.285b 16 (76) 70 (74) 60 (76) 12 (71) 0.971b
Tumour size           
<20 mm 12 (44) 43 (33) 46 (36) 13 (34)   10 (50) 35 (37) 33 (42) 6 (33)  
≥20 mm 15 (56) 87 (67) 82 (64) 25 (66) 0.815b 10 (50) 60 (63) 46 (58) 12 (67) 0.757b
ERα           
<10% 4 (16) 33 (26) 46 (37) 20 (53)   - - - -  
≥10% 21 (84) 95 (74) 79 (63) 18 (47) <0.001b - - - -  
PgR           
<10% 6 (24) 35 (29) 47 (39) 20 (56)   1 (5) 6 (7) 4 (5) 0  
≥10% 19 (76) 86 (71) 75 (61) 16 (44) 0.002b 18 (95) 84 (93) 73 (95) 16 (100) 0.464b
Ki-67 fraction (%)           
0-10 12 (48) 48 (40) 53 (45) 10 (29)   9 (47) 37 (42) 47 (64) 9 (56)  
11-25 7 (28) 38 (32) 34 (29) 7 (20)   6 (32) 30 (34) 20 (27) 3 (19)  
26-100 6 (24) 34 (28) 31 (26) 18 (51) 0.198a 4 (21) 21 (24) 6 (8) 4 (25) 0.016a
Cyclin D1 intensity           
absent/weak 8 (31) 67 (53) 81 (67) 29 (76)   3 (14) 39 (42) 40 (51) 9 (50)  
intermediate/strong 18 (69) 59 (47) 40 (33) 9 (24) <0.001b 18 (86) 54 (58) 38 (49) 9 (50) 0.010b
CCND1 amplification           
No 8 (44) 69 (84) 75 (89) 24 (96)   5 (36) 48 (80) 47 (84) 12 (92)  
Yes 10 (56) 13 (16) 9 (11) 1 (4) <0.001b 9 (64) 12 (20) 9 (16) 1 (8) 0.003b
  1. NHG=Nottingham histological grade, ERα=estrogen receptor, PgR=progesterone receptor.
  2. aSpearman´s rank correlation.
  3. bMann-Whitney U test.