| All patients, n= 500 |  | ER+patients, n=324 |  | ||||||
---|---|---|---|---|---|---|---|---|---|---|
 | YAP1 intensity, n=324 |  | YAP1 intensity, n=213 |  | ||||||
 | Absent | Weak | Intermediate | Strong | p-value | Absent | Weak | Intermediate | Strong | p-value |
 | n (%) | n (%) | n (%) | n (%) |  | n (%) | n (%) | n (%) | n (%) |  |
Variable | 28 (9) | 130 (40) | 128 (39) | 38 (12) | Â | 21 (10) | 95 (45) | 79 (37) | 18 (8) | Â |
NHG | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
I | 0 | 10 (8) | 11 (9) | 5 (13) | Â | 0 | 10 (11) | 11 (14) | 5 (28) | Â |
II | 13 (48) | 55 (44) | 56 (45) | 10 (27) | Â | 12 (57) | 48 (50) | 51 (65) | 9 (50) | Â |
III | 14 (52) | 60 (48) | 57 (46) | 22 (60) | 0.932a | 9 (43) | 37 (39) | 16 (21) | 4 (22) | 0.001a |
Lymph node status | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Negative | 7 (25) | 35 (27) | 34 (27) | 15 (41) | Â | 5 (24) | 25 (26) | 19 (24) | 5 (29) | Â |
Positive | 21 (75) | 94 (73) | 94 (73) | 22 (59) | 0.285b | 16 (76) | 70 (74) | 60 (76) | 12 (71) | 0.971b |
Tumour size | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
<20 mm | 12 (44) | 43 (33) | 46 (36) | 13 (34) | Â | 10 (50) | 35 (37) | 33 (42) | 6 (33) | Â |
≥20 mm | 15 (56) | 87 (67) | 82 (64) | 25 (66) | 0.815b | 10 (50) | 60 (63) | 46 (58) | 12 (67) | 0.757b |
ERα |  |  |  |  |  |  |  |  |  |  |
<10% | 4 (16) | 33 (26) | 46 (37) | 20 (53) | Â | - | - | - | - | Â |
≥10% | 21 (84) | 95 (74) | 79 (63) | 18 (47) | <0.001b | - | - | - | - |  |
PgR | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
<10% | 6 (24) | 35 (29) | 47 (39) | 20 (56) | Â | 1 (5) | 6 (7) | 4 (5) | 0 | Â |
≥10% | 19 (76) | 86 (71) | 75 (61) | 16 (44) | 0.002b | 18 (95) | 84 (93) | 73 (95) | 16 (100) | 0.464b |
Ki-67 fraction (%) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
0-10 | 12 (48) | 48 (40) | 53 (45) | 10 (29) | Â | 9 (47) | 37 (42) | 47 (64) | 9 (56) | Â |
11-25 | 7 (28) | 38 (32) | 34 (29) | 7 (20) | Â | 6 (32) | 30 (34) | 20 (27) | 3 (19) | Â |
26-100 | 6 (24) | 34 (28) | 31 (26) | 18 (51) | 0.198a | 4 (21) | 21 (24) | 6 (8) | 4 (25) | 0.016a |
Cyclin D1 intensity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
absent/weak | 8 (31) | 67 (53) | 81 (67) | 29 (76) | Â | 3 (14) | 39 (42) | 40 (51) | 9 (50) | Â |
intermediate/strong | 18 (69) | 59 (47) | 40 (33) | 9 (24) | <0.001b | 18 (86) | 54 (58) | 38 (49) | 9 (50) | 0.010b |
CCND1 amplification | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
No | 8 (44) | 69 (84) | 75 (89) | 24 (96) | Â | 5 (36) | 48 (80) | 47 (84) | 12 (92) | Â |
Yes | 10 (56) | 13 (16) | 9 (11) | 1 (4) | <0.001b | 9 (64) | 12 (20) | 9 (16) | 1 (8) | 0.003b |