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Table 1 Correlations of YAP1 protein expression and clinical and molecular parameters of the screening cohort (n=144)

From: Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response

  All patients, n=144   ER+patients, n=125  
  YAP1 intensity, n=117   YAP1 intensity, n=99  
  Absent Weak Intermediate Strong   Absent Weak Intermediate Strong  
n (%) n (%) n (%) n (%) p-value n (%) n (%) n (%) n (%) p-value
Variable 4 (3) 52 (44) 38 (33) 23 (20)   4 (4) 46 (47) 35 (35) 14 (14)  
NHG           
I 0 3 (6) 6 (16) 2 (9)   0 3 (7) 6 (17) 2 (14)  
II 2 (50) 26 (50) 19 (50) 9 (41)   2 (50) 25 (54) 19 (54) 9 (64)  
III 2 (50) 23 (44) 13 (34) 11 (50) 0.646a 2 (50) 18 (39) 10 (29) 3 (21) 0.060a
Lymph node status           
Negative 1 (25) 26 (52) 22 (65) 12 (63)   1 (25) 23 (51) 20 (63) 10 (83)  
Positive 3 (75) 24 (48) 12 (35) 7 (37) 0.128b 3 (75) 22 (49) 12 (37) 2 (17) 0.022b
Tumour size           
<20 mm 0 26 (50) 18 (47) 9 (41)   0 24 (55) 18 (51) 8 (57)  
≥20 mm 4 (100) 26 (50) 20 (53) 13 (59) 0.995b 4 (100) 22 (45) 17 (49) 6 (43) 0.347b
ERα           
<10% 0 6 (12) 3 (8) 8 (36)   - - - -  
≥10% 4 (100) 46 (88) 35 (92) 14 (64) 0.030b - - - -  
PgR           
<10% 1 (25) 17 (33) 9 (24) 14 (64)   1 (25) 12 (26) 6 (17) 6 (43)  
≥10% 3 (75) 35 (67) 29 (76) 8 (36) 0.084b 3 (75) 34 (74) 29 (83) 8 (57) 0.691b
Ki-67 fraction (%)           
0-10 0 0 3 (8) 2 (10)   0 0 3 (9) 2 (15)  
11-25 2 (67) 20 (44) 18 (49) 7 (33)   2 (67) 18 (45) 18 (53) 6 (46)  
26-100 1 (33) 25 (56) 16 (43) 12 (57) 0.626a 1 (33) 22 (55) 13 (38) 5 (39) 0.091a
Cyclin D1 intensity           
Negative/Low 0 19 (51) 20 (67) 12 (86)   0 17 (53) 17 (63) 6 (75)  
Moderate/High 4 (100) 18 (49) 10 (33) 2 (14) 0.002b 4 (100) 15 (47) 10 (37) 2 (25) 0.040b
  1. NHG=Nottingham histological grade, ER=estrogen receptor, PgR=progesterone receptor.
  2. aSpearman´s rank correlation.
  3. bMann-Whitney U test.