BMC Cancer

Table 1 Correlations of YAP1 protein expression and clinical and molecular parameters of the screening cohort (n=144)

From: Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response

	All patients, n=144					ER⁺patients, n=125
	YAP1 intensity, n=117					YAP1 intensity, n=99
	Absent	Weak	Intermediate	Strong		Absent	Weak	Intermediate	Strong
	n (%)	n (%)	n (%)	n (%)	p-value	n (%)	n (%)	n (%)	n (%)	p-value
Variable	4 (3)	52 (44)	38 (33)	23 (20)		4 (4)	46 (47)	35 (35)	14 (14)
NHG
I	0	3 (6)	6 (16)	2 (9)		0	3 (7)	6 (17)	2 (14)
II	2 (50)	26 (50)	19 (50)	9 (41)		2 (50)	25 (54)	19 (54)	9 (64)
III	2 (50)	23 (44)	13 (34)	11 (50)	0.646^a	2 (50)	18 (39)	10 (29)	3 (21)	0.060^a
Lymph node status
Negative	1 (25)	26 (52)	22 (65)	12 (63)		1 (25)	23 (51)	20 (63)	10 (83)
Positive	3 (75)	24 (48)	12 (35)	7 (37)	0.128^b	3 (75)	22 (49)	12 (37)	2 (17)	0.022^b
Tumour size
<20 mm	0	26 (50)	18 (47)	9 (41)		0	24 (55)	18 (51)	8 (57)
≥20 mm	4 (100)	26 (50)	20 (53)	13 (59)	0.995^b	4 (100)	22 (45)	17 (49)	6 (43)	0.347^b
ERα
<10%	0	6 (12)	3 (8)	8 (36)		-	-	-	-
≥10%	4 (100)	46 (88)	35 (92)	14 (64)	0.030^b	-	-	-	-
PgR
<10%	1 (25)	17 (33)	9 (24)	14 (64)		1 (25)	12 (26)	6 (17)	6 (43)
≥10%	3 (75)	35 (67)	29 (76)	8 (36)	0.084^b	3 (75)	34 (74)	29 (83)	8 (57)	0.691^b
Ki-67 fraction (%)
0-10	0	0	3 (8)	2 (10)		0	0	3 (9)	2 (15)
11-25	2 (67)	20 (44)	18 (49)	7 (33)		2 (67)	18 (45)	18 (53)	6 (46)
26-100	1 (33)	25 (56)	16 (43)	12 (57)	0.626^a	1 (33)	22 (55)	13 (38)	5 (39)	0.091^a
Cyclin D1 intensity
Negative/Low	0	19 (51)	20 (67)	12 (86)		0	17 (53)	17 (63)	6 (75)
Moderate/High	4 (100)	18 (49)	10 (33)	2 (14)	0.002^b	4 (100)	15 (47)	10 (37)	2 (25)	0.040^b

NHG=Nottingham histological grade, ER=estrogen receptor, PgR=progesterone receptor.
^aSpearman´s rank correlation.
^bMann-Whitney U test.

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