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Table 7 Intracellular chemokine expression after xenotransplantation

From: Intracellular coexpression of CXC- and CC– chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation

 

CXCL9

CXCL10

CXCL11

CXCL12

CCL19

CCL21

CCL27

CCL28

 

%

MFI

%

MFI

%

MFI

%

MFI

%

MFI

%

MFI

%

MFI

%

MFI

WM-115

28.31

2.06

0.46

1.12

2.66

1.24

81.77

3.96

98.79

20.00

15.55

1.65

94.06

4.89

ns

0.94

WM-115-X

ns

1.10

ns

0.90

ns

0.96

0.30

0.94

50.38

3.80

ns

1.05

22.39

1.62

ns

0.97

WM-115-CX

50.39

5.36

4.33

2.54

15.24

5.25

79.83

5.08

98.64

36.76

14.46

4.24

98.17

13.36

3.51

2.98

WM-266

71.84

4.57

15.19

1.74

46.26

3.24

98.24

9.56

98.58

30.17

60.21

3.71

98.50

11.38

1.14

1.25

WM-266-X

2.12

1.46

2.53

1.28

22.73

1.93

3.81

1.42

81.95

10.43

2.38

1.33

54.41

3.39

1.25

1.19

WM-266-CX

67.84

7.02

3.72

1.41

37.75

4.98

95.52

14.66

98.10

43.82

50.06

4.00

97.12

12.36

0.29

0.97

  1. Mean percentage (%) and mean fluorescence index (MFI; calculated as the ratio between the mean fluorescence of samples stained with the mAb anti-receptor and correspondent isotypic control) of cells which significantly expressed (p < 0.05) chemokine ligands intracellularly. WM-115 and WM-266 represent the mean values of the original cell lines; WM-115-X and WM-266-X represent the mean values of the different xenografts; WM-115-CX and WM-266-CX represent the mean values of the different cell lines obtained after culturing the xenografts.