Figure 2

EMF guidance caused more accumulation and retention of ¹³¹ I-hVEGF siRNA/SilenceMag and hVEGF siRNA/SilenceMag in the HCC tumor compared with no EMF and control. A: The biodistribution of intravenous 131I-hVEGF siRNA/SilenceMag in HCC tumors as well as different organs 30 min after administered to HepG2 xenografts in the presence of EMF (A) or in the absence of EMF (B). B: ¹³¹I-hVEGF siRNA/SilenceMag scintigraphy taken at 30 min after injection in the HepG2 HCC xenograft. Left: in the presence of EMF. Right: in the absence of EMF. C: MRI images of nude mice bearing the HepG2 HCC xenograft 30 min after intravenously injection of 131I-hVEGF siRNA/SilenceMag. Upper (T1WI): I, in the absence of EMF. II, in the presence of EMF. Lower (T2WI): III, in the absence of EMF. IV, in the presence of EMF.