Table 1 Information of genes detected by double or triple-combination array analysis
Gene symbol | Function of encoded protein | Expression in tumor (log2 ratio) | SNP array | Methylation value in tumor and noncancerous liver | Methylation in HCC cell lines |
|---|---|---|---|---|---|
MT1G | A preserver of biologically essential metals homeostasis | -3.1~3.6 | No LOH | N/A | 3/5 (60.0%) |
EFEMP1 | A family of extracellular matrix protien | -3.7~4.1 | No LOH | N/A | 7/9 (77.8%) |
LIFR | A component of signaling complex in IL-6 cytokine family | -3.7~5.1 | No LOH | N/A | 6/6 (100.0%) |
FBLN1 | A family of extracellular matrix protein | -2.8~3.4 | No LOH | N/A | 4/5 (80.0%) |
RELN | A family of extracellular matrix protein | -3.0 | No LOH | N/A | 2/5 (40.0%) |
AKAP12 | A scafford protein of protein kinase A signaling pathway | -2.8 | No LOH | N/A | 3/6 (50.0%) |
BLMH | A cytoplasmic cysteine peptidase | -1.3 | No LOH | 0.530 / 0.089 | 2/5 (40.0%) |
ESR1 | A nuclear hormone receptor | -2.5 | No LOH | 0.775 / 0.093 | 5/9 (55.6%) |
DCDC2 | An enhancer of microtubule polymerization | -2.2 | No LOH | 0.846 / 0.212 | 6/9 (66.7%) |
DNM3 | A member of dynamin family and related to endocytosis | -1.0 | No LOH | 0.879 / 0.213 | 8/9 (88.9%) |
COL1A1 | A major component of type I collagen | -1.1 | No LOH | 0.557 / 0.084 | 4/6 (66.7%) |