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Table 1 Information of genes detected by double or triple-combination array analysis

From: Identification of the collagen type 1 alpha 1 gene (COL1A1) as a candidate survival-related factor associated with hepatocellular carcinoma

Gene symbol Function of encoded protein Expression in tumor (log2 ratio) SNP array Methylation value in tumor and noncancerous liver Methylation in HCC cell lines
MT1G A preserver of biologically essential metals homeostasis -3.1~3.6 No LOH N/A 3/5 (60.0%)
EFEMP1 A family of extracellular matrix protien -3.7~4.1 No LOH N/A 7/9 (77.8%)
LIFR A component of signaling complex in IL-6 cytokine family -3.7~5.1 No LOH N/A 6/6 (100.0%)
FBLN1 A family of extracellular matrix protein -2.8~3.4 No LOH N/A 4/5 (80.0%)
RELN A family of extracellular matrix protein -3.0 No LOH N/A 2/5 (40.0%)
AKAP12 A scafford protein of protein kinase A signaling pathway -2.8 No LOH N/A 3/6 (50.0%)
BLMH A cytoplasmic cysteine peptidase -1.3 No LOH 0.530 / 0.089 2/5 (40.0%)
ESR1 A nuclear hormone receptor -2.5 No LOH 0.775 / 0.093 5/9 (55.6%)
DCDC2 An enhancer of microtubule polymerization -2.2 No LOH 0.846 / 0.212 6/9 (66.7%)
DNM3 A member of dynamin family and related to endocytosis -1.0 No LOH 0.879 / 0.213 8/9 (88.9%)
COL1A1 A major component of type I collagen -1.1 No LOH 0.557 / 0.084 4/6 (66.7%)
  1. LOH, loss of heterozygosity; N/A, not applicable.