The relationship between miR-372 and ATAD2. (a) Significant down-regulation of miR-372 in paired HCC/NT samples was defined as a log2-fold change < -1. (b) miR-372 expression was negatively correlated with ATAD2 expression in 45 paired samples. (c) Luciferase assay with wild-type and miR-372 binding site-mutated ATAD2-3′ UTR in the presence of a miR-372 expression plasmid. Mutations are underlined and italicized. (d) miR-372 binding site in the ATAD2 3′ UTR in different species. The seed sequence is under the white box. (e) Relative luciferase activity analyses. The relative luciferase activity of the pGV214 group was set as 1.