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Table 3 Subgroup and Sensitivity analysis

From: Prognostic significance of glypican-3 in hepatocellular carcinoma: a meta-analysis

Variables (cut-off value)*

Number of study

HR/OR

95% CI

p

I2

OS

6

1.96

1.51-2.55

0.000

0%

  0% cut -off value Of GPC3

1

1.35

0.57-3.21

0.000

NA

  10% cut -off value Of GPC3

3

1.84

1.25-2.71

0.002

0%

  20% cut- off value Of GPC3

1

2.20

1.25-3.89

0.006

NA

  25% cut- off value Of GPC3

1

2.29

1.35-3.89

0.002

NA

  Exclusion of Liang et al.

5

2.04

1.55-2.68

0.000

0%

  Studies with multivariate analysis

4

2.06

1.56-2.73

0.000

0%

  Studies without multivariate analysis

2

1.43

0.70-2.91

0.32

0%

DFS

7

1.99

1.57-2.51

0.000

34%

  0% cut- off value Of GPC3

0

NA

NA

NA

NA

  10% cut -off value Of GPC3

4

1.60

1.14-2.25

0.007

33%

  20% cut- off value Of GPC3

1

3.60

1.81-7.14

0.000

NA

  25% cut- off value Of GPC3

1

2.14

1.39-3.29

0.000

NA

  Exclusion of Yorita et al.

6

1.83

1.43-2.36

0.000

14%

  Studies with multivariate analyis

3

2.43

1.76-3.35

0.000

0%

  Studies without multivariate analyis

4

1.58

1.12-2.22

0.010

29%

Tumor grade

4

3.30

2.04-5.33

0.000

34%

  0% cut- off value Of GPC3

0

NA

NA

NA

NA

  10% cut -off value Of GPC3

2

5.55

1.92-16.06

0.002

0%

  20% cut- off value Of GPC3

1

4.53

2.26-9.06

0.000

NA

  25% cut- off value Of GPC3

1

1.61

0.70-3.73

0.26

NA

  Exclusion of Yorita et al. l

3

2.45

1.26-4.78

0.008

39%

TNM stage

4

2.26

1.00-5.12

0.05

54%

  0% cut- off value Of GPC3

0

NA

NA

NA

NA

  10% cut -off value Of GPC3

3

1.78

0.54-5.87

0.34

57%

  20% cut- off value Of GPC3

1

3.40

1.87-6.18

0.000

NA

  25% cut- off value Of GPC3

0

NA

NA

NA

NA

  Exclusion of Yorita et al.

3

1.78

0.54-5.87

0.34

57%

Vascular invasion

4

2.43

1.23-4.82

0.01

52%

  0% cut- off value Of GPC3

0

NA

NA

NA

NA

  10% cut- off value Of GPC3

2

3.41

0.52-22.41

0.20

71%

  20% cut- off value Of GPC3

1

3.34

1.85-6.05

0.000

NA

  25% cut- off value Of GPC3

1

1.36

0.56-3.30

0.50

NA

  Exclusion of Yorita et al.

3

2.11

0.81-5.49

0.13

52%

Tumor size5 cm

4

1.30

0.88-1.93

0.19

0%

  0% cut- off value Of GPC3

0

NA

NA

NA

NA

  10% cut- off value Of GPC3

2

1.08

0.46-2.53

0.78

0%

  20% cut- off value Of GPC3

1

1.19

0.67-2.11

0.56

NA

  25% cut- off value Of GPC3

1

1.70

0.84-3.43

0.14

NA

  Exclusion of Yorita et al.

3

1.41

0.82-2.42

0.21

0%

Tumor multifocality

4

2.42

0.94-6.23

0.07

72%

  0% cut- off value Of GPC3

0

NA

NA

NA

NA

  10% cut- off value Of GPC3

2

4.59

0.41-51.05

0.21

83%

  20% cut- off value Of GPC3

1

1.06

0.53-2.12

0.86

NA

  25% cut- off value Of GPC3

1

2.71

1.19-6.13

0.02

NA

  Exclusion of Yorita et al.

3

3.50

1.09-11.18

0.03

66%

  1. GPC3:glypican3; HR: hazard ratio; OR: odds ratios; CI: confidence interval; OS: overall survival; DFS: disease-free survival; NA: not available.
  2. *High glypican-3 cut-off level was scored according to 0%, 10%, 20%, and 25% of the percentage of positive tumor cells by immunohistochemical staining.
  3. A HR >1 implies a worse prognosis in the group with GPC3 overexpression; while an OR > 1 indicated higher probability for high tumor grade, later TNM stage, the presence of vascular invasion,tumor size ≥ 5 cm and tumor multifocality in HCC with GPC3 overexpression.