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Table 3 Subgroup and Sensitivity analysis

From: Prognostic significance of glypican-3 in hepatocellular carcinoma: a meta-analysis

Variables (cut-off value)* Number of study HR/OR 95% CI p I2
OS 6 1.96 1.51-2.55 0.000 0%
  0% cut -off value Of GPC3 1 1.35 0.57-3.21 0.000 NA
  10% cut -off value Of GPC3 3 1.84 1.25-2.71 0.002 0%
  20% cut- off value Of GPC3 1 2.20 1.25-3.89 0.006 NA
  25% cut- off value Of GPC3 1 2.29 1.35-3.89 0.002 NA
  Exclusion of Liang et al. 5 2.04 1.55-2.68 0.000 0%
  Studies with multivariate analysis 4 2.06 1.56-2.73 0.000 0%
  Studies without multivariate analysis 2 1.43 0.70-2.91 0.32 0%
DFS 7 1.99 1.57-2.51 0.000 34%
  0% cut- off value Of GPC3 0 NA NA NA NA
  10% cut -off value Of GPC3 4 1.60 1.14-2.25 0.007 33%
  20% cut- off value Of GPC3 1 3.60 1.81-7.14 0.000 NA
  25% cut- off value Of GPC3 1 2.14 1.39-3.29 0.000 NA
  Exclusion of Yorita et al. 6 1.83 1.43-2.36 0.000 14%
  Studies with multivariate analyis 3 2.43 1.76-3.35 0.000 0%
  Studies without multivariate analyis 4 1.58 1.12-2.22 0.010 29%
Tumor grade 4 3.30 2.04-5.33 0.000 34%
  0% cut- off value Of GPC3 0 NA NA NA NA
  10% cut -off value Of GPC3 2 5.55 1.92-16.06 0.002 0%
  20% cut- off value Of GPC3 1 4.53 2.26-9.06 0.000 NA
  25% cut- off value Of GPC3 1 1.61 0.70-3.73 0.26 NA
  Exclusion of Yorita et al. l 3 2.45 1.26-4.78 0.008 39%
TNM stage 4 2.26 1.00-5.12 0.05 54%
  0% cut- off value Of GPC3 0 NA NA NA NA
  10% cut -off value Of GPC3 3 1.78 0.54-5.87 0.34 57%
  20% cut- off value Of GPC3 1 3.40 1.87-6.18 0.000 NA
  25% cut- off value Of GPC3 0 NA NA NA NA
  Exclusion of Yorita et al. 3 1.78 0.54-5.87 0.34 57%
Vascular invasion 4 2.43 1.23-4.82 0.01 52%
  0% cut- off value Of GPC3 0 NA NA NA NA
  10% cut- off value Of GPC3 2 3.41 0.52-22.41 0.20 71%
  20% cut- off value Of GPC3 1 3.34 1.85-6.05 0.000 NA
  25% cut- off value Of GPC3 1 1.36 0.56-3.30 0.50 NA
  Exclusion of Yorita et al. 3 2.11 0.81-5.49 0.13 52%
Tumor size5 cm 4 1.30 0.88-1.93 0.19 0%
  0% cut- off value Of GPC3 0 NA NA NA NA
  10% cut- off value Of GPC3 2 1.08 0.46-2.53 0.78 0%
  20% cut- off value Of GPC3 1 1.19 0.67-2.11 0.56 NA
  25% cut- off value Of GPC3 1 1.70 0.84-3.43 0.14 NA
  Exclusion of Yorita et al. 3 1.41 0.82-2.42 0.21 0%
Tumor multifocality 4 2.42 0.94-6.23 0.07 72%
  0% cut- off value Of GPC3 0 NA NA NA NA
  10% cut- off value Of GPC3 2 4.59 0.41-51.05 0.21 83%
  20% cut- off value Of GPC3 1 1.06 0.53-2.12 0.86 NA
  25% cut- off value Of GPC3 1 2.71 1.19-6.13 0.02 NA
  Exclusion of Yorita et al. 3 3.50 1.09-11.18 0.03 66%
  1. GPC3:glypican3; HR: hazard ratio; OR: odds ratios; CI: confidence interval; OS: overall survival; DFS: disease-free survival; NA: not available.
  2. *High glypican-3 cut-off level was scored according to 0%, 10%, 20%, and 25% of the percentage of positive tumor cells by immunohistochemical staining.
  3. A HR >1 implies a worse prognosis in the group with GPC3 overexpression; while an OR > 1 indicated higher probability for high tumor grade, later TNM stage, the presence of vascular invasion,tumor size ≥ 5 cm and tumor multifocality in HCC with GPC3 overexpression.