From: Prognostic significance of glypican-3 in hepatocellular carcinoma: a meta-analysis
Variables (cut-off value)* | Number of study | HR/OR | 95% CI | p | I2 |
---|---|---|---|---|---|
OS | 6 | 1.96 | 1.51-2.55 | 0.000 | 0% |
0% cut -off value Of GPC3 | 1 | 1.35 | 0.57-3.21 | 0.000 | NA |
10% cut -off value Of GPC3 | 3 | 1.84 | 1.25-2.71 | 0.002 | 0% |
20% cut- off value Of GPC3 | 1 | 2.20 | 1.25-3.89 | 0.006 | NA |
25% cut- off value Of GPC3 | 1 | 2.29 | 1.35-3.89 | 0.002 | NA |
Exclusion of Liang et al. | 5 | 2.04 | 1.55-2.68 | 0.000 | 0% |
Studies with multivariate analysis | 4 | 2.06 | 1.56-2.73 | 0.000 | 0% |
Studies without multivariate analysis | 2 | 1.43 | 0.70-2.91 | 0.32 | 0% |
DFS | 7 | 1.99 | 1.57-2.51 | 0.000 | 34% |
0% cut- off value Of GPC3 | 0 | NA | NA | NA | NA |
10% cut -off value Of GPC3 | 4 | 1.60 | 1.14-2.25 | 0.007 | 33% |
20% cut- off value Of GPC3 | 1 | 3.60 | 1.81-7.14 | 0.000 | NA |
25% cut- off value Of GPC3 | 1 | 2.14 | 1.39-3.29 | 0.000 | NA |
Exclusion of Yorita et al. | 6 | 1.83 | 1.43-2.36 | 0.000 | 14% |
Studies with multivariate analyis | 3 | 2.43 | 1.76-3.35 | 0.000 | 0% |
Studies without multivariate analyis | 4 | 1.58 | 1.12-2.22 | 0.010 | 29% |
Tumor grade | 4 | 3.30 | 2.04-5.33 | 0.000 | 34% |
0% cut- off value Of GPC3 | 0 | NA | NA | NA | NA |
10% cut -off value Of GPC3 | 2 | 5.55 | 1.92-16.06 | 0.002 | 0% |
20% cut- off value Of GPC3 | 1 | 4.53 | 2.26-9.06 | 0.000 | NA |
25% cut- off value Of GPC3 | 1 | 1.61 | 0.70-3.73 | 0.26 | NA |
Exclusion of Yorita et al. l | 3 | 2.45 | 1.26-4.78 | 0.008 | 39% |
TNM stage | 4 | 2.26 | 1.00-5.12 | 0.05 | 54% |
0% cut- off value Of GPC3 | 0 | NA | NA | NA | NA |
10% cut -off value Of GPC3 | 3 | 1.78 | 0.54-5.87 | 0.34 | 57% |
20% cut- off value Of GPC3 | 1 | 3.40 | 1.87-6.18 | 0.000 | NA |
25% cut- off value Of GPC3 | 0 | NA | NA | NA | NA |
Exclusion of Yorita et al. | 3 | 1.78 | 0.54-5.87 | 0.34 | 57% |
Vascular invasion | 4 | 2.43 | 1.23-4.82 | 0.01 | 52% |
0% cut- off value Of GPC3 | 0 | NA | NA | NA | NA |
10% cut- off value Of GPC3 | 2 | 3.41 | 0.52-22.41 | 0.20 | 71% |
20% cut- off value Of GPC3 | 1 | 3.34 | 1.85-6.05 | 0.000 | NA |
25% cut- off value Of GPC3 | 1 | 1.36 | 0.56-3.30 | 0.50 | NA |
Exclusion of Yorita et al. | 3 | 2.11 | 0.81-5.49 | 0.13 | 52% |
Tumor size ≧ 5 cm | 4 | 1.30 | 0.88-1.93 | 0.19 | 0% |
0% cut- off value Of GPC3 | 0 | NA | NA | NA | NA |
10% cut- off value Of GPC3 | 2 | 1.08 | 0.46-2.53 | 0.78 | 0% |
20% cut- off value Of GPC3 | 1 | 1.19 | 0.67-2.11 | 0.56 | NA |
25% cut- off value Of GPC3 | 1 | 1.70 | 0.84-3.43 | 0.14 | NA |
Exclusion of Yorita et al. | 3 | 1.41 | 0.82-2.42 | 0.21 | 0% |
Tumor multifocality | 4 | 2.42 | 0.94-6.23 | 0.07 | 72% |
0% cut- off value Of GPC3 | 0 | NA | NA | NA | NA |
10% cut- off value Of GPC3 | 2 | 4.59 | 0.41-51.05 | 0.21 | 83% |
20% cut- off value Of GPC3 | 1 | 1.06 | 0.53-2.12 | 0.86 | NA |
25% cut- off value Of GPC3 | 1 | 2.71 | 1.19-6.13 | 0.02 | NA |
Exclusion of Yorita et al. | 3 | 3.50 | 1.09-11.18 | 0.03 | 66% |