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Table 2 Relative risks for esophageal cancer related to different metabolic risk factors in quintiles

From: Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580 000 subjects within the Me-Can project

Exposure   Adenocarcinoma Squamous cell carcinoma
  Quintile Mean (SD) Cases (n) Age and cohort stratified RR Adjusted RR1 Adjusted, RDR corrected RR1 Cases (n) Age and cohort stratified RR Adjusted RR1 Adjusted, RDR corrected RR1
BMI 1 20.7 (1.5) 5 1.00 1.00 1.00 55 1.00 1.00 1.00
2 23.0 (1.1) 18 3.13 (1.16–8.44) 3.37 (1.25–9.10) 3.86 (1.28–11.66) 29 0.44 (0.28–0.70) 0.50 (0.32–0.79) 0.47 (0.28–0.77)
3 24.7 (1.0) 18 2.81 (1.04–7.60) 3.17 (1.17–8.57) 3.61 (1.19–10.91) 46 0.62 (0.42–0.92) 0.76 (0.51–1.12) 0.73 (0.47–1.14)
4 26.8 (1.0) 31 4.41 (1.71–11.39) 5.19 (2.00–13.42) 6.24 (2.17–17.97) 30 0.37 (0.23–0.57) 0.46 (0.30–0.72) 0.42 (0.26–0.70)
5 31.3 (3.3) 42 5.96 (2.34–15.16) 7.34 (2.88–18.68) 9.18 (3.24–25.96) 24 0.29 (0.18–0.47) 0.38 (0.23–0.62) 0.34 (0.20–0.58)
Ptrend     <0.0001 <0.0001 <0.0001   <0.0001 <0.0001  
Adjusted RR per increment of 5 1   1.64 (1.35–2.00) 1.78 (1.45–2.17)    0.56 (0.44–0.70) 0.62 (0.50–0.79)  
Mid blood pressure, mmHg 1 88 (5.7) 14 1.00 1.00 1.00 21 1.00 1.00 1.00
2 97 (4.1) 18 1.12 (0.56–2.25) 0.99 (0.49–2.00) 0.99 (0.27–3.58) 30 1.29 (0.74–2.26) 1.47 (0.84–2.58) 2.04 (0.73–5.70)
3 103 (3.8) 22 1.24 (0.63–2.44) 1.15 (0.58–2.27) 1.29 (0.37–4.50) 23 0.87 (0.48–1.58) 1.14 (0.63–2.08) 1.28 (0.43–3.83)
4 110 (4.1) 25 1.13 (0.58–2.19) 1.01 (0.52–1.98) 1.02 (0.30–3.50) 49 1.55 (0.93–2.61) 2.27 (1.35–3.83) 4.51 (1.72–11.81)
5 125 (10.4) 35 1.32 (0.70–2.51) 1.09 (0.57–2.10) 1.17 (0.35–3.90) 60 1.59 (0.95–2.66) 2.60 (1.54–4.39) 5.79 (2.21–15.20)
Ptrend     0.44 0.81    0.035 <0.0001  
Adjusted RR per increment of 10 mmHg 1   1.09 (0.95–1.25) 1.03 (0.89–1.19)    1.17 (1.05–1.29) 1.30 (1.17–1.44)  
Glucose, mmol/L 1 4.1 (0.5) 19 1.00 1.00 1.00 34 1.00 1.00 1.00
2 4.7 (0.3) 21 1.06 (0.57–1.97) 1.07 (0.57–2.01) 1.29 (0.14–12.21) 33 0.96 (0.59–1.55) 1.04 (0.64–1.69) 1.16 (0.20–6.55)
3 5.1 (0.3) 20 0.96 (0.51–1.81) 0.95 (0.51–1.80) 0.85 (0.09–8.32) 38 1.07 (0.69–1.70) 1.20 (0.75–1.91) 1.90 (0.35–10.27)
4 5.5 (0.3) 28 1.28 (0.71–2.31) 1.32 (0.73–2.38) 2.69 (0.32–22.70) 31 0.88 (0.54–1.44) 1.02 (0.62–1.68) 1.08 (0.18–6.43)
5 6.8 (1.9) 26 1.07 (0.59–1.95) 1.04 (0.57.1.90) 1.14 (0.13–10.12) 48 1.21 (0.77–1.89) 1.44 (0.92–2.27) 3.76 (0.74–19.17)
Ptrend     0.62 0.70    0.50 0.14  
Adjusted RR per increment of 1 mmol/l 2,3   1.14 (0.93–1.38) 1.12 (0.92–1.38)    1.16 (0.99–1.35) 1.22 (1.04–1.42)  
Cholesterol, mmol/L 1 4.2 (0.5) 13 1.00 1.00 1.00 22 1.00 1.00 1.00
2 5.0 (0.3) 25 1.60 (0.82–3.15) 1.48 (0.75–2.91) 1.82 (0.65–5.08) 30 1.09 (0.63–1.89) 1.08 (0.62–1.88) 1.13 (0.49–2.62)
3 5.6 (0.3) 18 1.01 (0.49–2.08) 0.93 (0.45–1.92) 0.90 (0.30–2.69) 36 1.16 (0.68–1.99) 1.20 (0.70–2.05) 1.32 (0.59–2.99)
4 6.2 (0.3) 27 1.34 (0.68–2.63) 1.22 (0.62–2.40) 1.36 (0.49–3.80) 44 1.26 (0.75–2.12) 1.32 (0.78–2.21) 1.52 (0.69–3.35)
5 7.4 (0.8) 31 1.34 (0.69–2.62) 1.22 (0.63–2.37) 1.35 (0.49–3.72) 51 1.32 (0.79–2.21) 1.42 (0.85–2.37) 1.70 (0.78–3.71)
Ptrend     0.68 0.86    0.22 0.12  
Adjusted RR per increment of 1 mmol/l 2   0.99 (0.84–1.17) 0.94 (0.80–1.10)    1.06 (0.94–1.21) 1.08 (0.95–1.22)  
Triglycerides, mmol/L 1 0.72 (0.17) 14 1.00 1.00 1.00 27 1.00 1.00 1.00
2 1.03 (0.21) 18 1.20 (0.60–2.42) 1.03 (0.51–2.07) 1.05 (0.26–4.22) 39 1.28 (0.78–2.09) 1.26 (0.77–2.06) 1.57 (0.59–4.17)
3 1.33 (0.29) 16 0.98 (0.48–2.02) 0.78 (0.38–1.60) 0.61 (0.15.2.55) 34 1.05 (0.63–1.74) 1.05 (0.63–1.75) 1.11 (0.40–3.04)
4 1.77 (0.42) 33 1.95 (1.04–3.65) 1.42 (0.75–2.69) 2.00 (0.56–7.09) 39 1.14 (0.70–1.87) 1.22 (0.74–2.01) 1.48 (0.55–3.99)
5 3.12 (1.54) 28 1.60 (0.84–3.06) 1.05 (0.54–2.05) 1.11 (0.30–4.15) 44 1.24 (0.77–2.02) 1.45 (0.87–2.39) 2.07 (0.77–5.61)
Ptrend     0.038 0.51    0.58 0.22  
Adjusted RR per increment of 1 mmol/l 2,4   1.35 (1.12–1.61) 1.13 (0.93–1.38)    1.15 (0.98–1.34) 1.19 (1.01–1.40)  
  1. All analyses were stratified by study cohort and birth-year category. See text for correction of regression dilution bias.
  2. 1Adjusted for sex, age at baseline (continuous) smoking status and quintiles of BMI. 2Adjusted for age at baseline (continuous), smoking status, quintiles of BMI and fasting time. 3Outliers >10 mmol/l are excluded. 4Outliers >6 mmol/l are excluded.
  3. Abbreviations: CI confidence interval, RR relative risk, SD standard deviation, BMI body mass index, Mid BP: mid blood pressure, RDR regression dilution ratio.