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Figure 4 | BMC Cancer

Figure 4

From: Integrity of the LXXLL motif in Stat6 is required for the inhibition of breast cancer cell growth and enhancement of differentiation in the context of progesterone

Figure 4

Stat6 mediates the induction of p21 and p27 gene expression by progesterone. T47D cells, treated with or without progesterone (30nM) and transfected with control or Stat6 siRNAs (500 ng), were harvested at the indicated times for RNA (A) and protein (B) extraction. (A) Quantitative RT-PCR analyses. mRNA levels are expressed relative to levels in vehicle-treated control siRNA-transfected cells harvested at 24 h, arbitrarily set as 1. *P ≤ 0.05 versus control. (B) Western blotting of p21 and p27 with GADPH as control.

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