P4HA2 is associated with collagen expression and poor prognosis in human breast cancer.
(A-C) Scatterplot of correlated mRNA levels between P4HA2 and (A)
Col3A1, and (C)
Col4A1 in normal and malignant breast tissues (n = 593). The mRNA levels of P4HA2 were acquired from the TCGA microarray dataset generated from human breast cancer. (D)
P4HA2 mRNA levels in IBC (invasive breast carcinoma) (n = 76), IDBC (invasive ductal breast carcinoma) (n = 398) and ILBC (invasive lobular breast carcinoma) (n = 36) is higher than normal breast tissue (n = 61). (E)
P4HA2 mRNA expression is higher in ERBB2 (epidermal growth factor receptor 2) negative tumors than in ERBB2-positive cancer tissues. (F)
P4HA2 mRNA levels are associated with stages of breast cancer. (G) Kaplan-Meier survival analysis showed the association between P4HA2 expression and clinical outcomes. Breast cancer patients were grouped by ER status (ER-positive, n = 1452; ER-negative, n = 473). Tumor samples were classified into low and high P4HA2 expression based on the mRNA levels. Tumor had high P4HA2 expression levels in a shorter overall survival period. The association of P4HA2 expression and clinical outcome is ER status independent (*p < 0.05; **p < 0.01; ***p < 0.001).