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Table 1 Experimental drugs used in 2D and 3D cultures with respective viabilities

From: 3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

Name Class Concentration Viability after treatment,%
    2D 3D
Gemcitabine nucleoside analogue 1 μM 63 83
H107 microtubulin inhibitor 10 μM 10 97
CB5 microtubulin inhibitor 10 μM 58 93
CB7 microtubulin inhibitor 10 μM 55 100
CB13 microtubulin inhibitor 10 μM 70 95
AXP-107-11 genistein derivative 100 μM 40 65
6-MP mercaptopurine 200 μM 53 97
6-MPR mercaptopurine 200 μM 52 95
MT100 allicin derivative 200 μM 19 37
Allicin diallyl thiosulfinate 200 μM 19 46
act16412 sHH inhibitor 20 μM 72 100
GANT61 sHH inhibitor 20 μM 85 100
  1. The concentrations with the greatest effect are recorded. For details see Figure 7.