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Table 1 Experimental drugs used in 2D and 3D cultures with respective viabilities

From: 3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

Name

Class

Concentration

Viability after treatment,%

   

2D

3D

Gemcitabine

nucleoside analogue

1 μM

63

83

H107

microtubulin inhibitor

10 μM

10

97

CB5

microtubulin inhibitor

10 μM

58

93

CB7

microtubulin inhibitor

10 μM

55

100

CB13

microtubulin inhibitor

10 μM

70

95

AXP-107-11

genistein derivative

100 μM

40

65

6-MP

mercaptopurine

200 μM

53

97

6-MPR

mercaptopurine

200 μM

52

95

MT100

allicin derivative

200 μM

19

37

Allicin

diallyl thiosulfinate

200 μM

19

46

act16412

sHH inhibitor

20 μM

72

100

GANT61

sHH inhibitor

20 μM

85

100

  1. The concentrations with the greatest effect are recorded. For details see Figure 7.