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Table 1 Ovarian cancer patient demographics by ß-blocker use

From: Use of ß-blockers and mortality following ovarian cancer diagnosis: a population-based cohort study

  Nonusers Current users Previous users
Number (%) 6,166 (93.06) 373 (5.63) 87 (1.31)
Age at diagnosis, years    
 Median age (IQR) 65 (56–75) 66 (56–74) 63 (55–73)
 20-40 213 (3.45) 13 (3.49) 1 (1.15)
 41-60 1,982 (32.14) 118 (31.64) 32 (36.78)
 61-80 3,188 (51.70) 197 (52.82) 42 (48.28)
 >80 783 (12.70) 45 (12.06) 12 (13.79)
Stageb    
 Localized 1,848 (29.97) 128 (34.32) 28 (32.18)
 Regional 1,931 (31.32) 97 (26.01) 16 (18.39)
 Distant 1,920 (31.14) 111 (29.76) 33 (37.93)
 Unknown/missing 467 (7.57) 37 (9.92) 10 (11.49)
Comorbidity levelc    
 Low 4,127 (66.93) 251 (67.29) 58 (66.67)
 Moderate 1,512 (24.52) 88 (23.59) 26 (29.89)
 High 527 (8.55) 34 (9.12) 3 (3.45)
Comorbidities    
 Hypertension 681 (11.04) 45 (12.06) 12 (13.79)
 Obesity 71 (1.15) 2 (0.54) 0 (0.00)
 Atrial fibrillation/flutter 222 (3.60) 22 (5.90) 8 (9.20)
 Angina pectoris 257 (4.17) 9 (2.41) 0 (0.00)
 Myocardial infarction 160 (2.59) 10 (2.68) 2 (2.30)
 Congestive heart failure 183 (2.97) 12 (3.22) 4 (4.60)
 Esophageal varices 5 (0.08) 1 (0.27) 0 (0.00)
 Tremor 4 (0.06) 0 (0.00) 0 (0.00)
 Anxiety 41 (0.66) 1 (0.27) 1 (1.15)
 Thyrotoxicosis 182 (2.95) 16 (4.29) 5 (5.75)
 COPD 227 (3.68) 13 (3.49) 4 (4.60)
 Migraines 78 (1.27) 3 (0.80) 2 (2.30)
 Stroke 223 (3.62) 21 (5.63) 4 (4.60)
 Chronic kidney disease 81 (1.31) 5 (1.34) 3 (3.45)
 Hysterectomy 358 (5.81) 24 (6.43) 7 (8.05)
 Tubal sterilization 204 (3.31) 11 (2.95) 3 (3.45)
Comedication use    
 ACE-inhibitors 351 (5.69) 104 (27.88) 30 (34.48)
 ARBs 198 (3.21) 60 (16.09) 16 (18.39)
 Calcium channel blockers 407 (6.60) 112 (30.03) 31 (35.63)
 Diuretics 1,276 (20.69) 234 (62.73) 67 (77.01)
 Non-aspirin NSAIDs 1,852 (30.04) 220 (58.98) 51 (58.62)
 Aspirin 525 (8.51) 157 (42.09) 40 (45.98)
 Statins 320 (5.19) 111 (29.76) 28 (32.18)
 HRT 1,165 (18.89) 126 (33.78) 33 (37.93)
 Antipsychotics 336 (5.45) 41 (10.99) 8 (9.20)
 Anxiolytics 285 (4.62) 22 (5.90) 7 (8.05)
 Antidepressants 816 (13.23) 100 (26.81) 24 (27.59)
  1. ACE: angiotensin-converting enzyme; ARBs: angiotensin receptor blockers; NSAIDs: nonsteroidal anti-inflammatory drugs.
  2. a Defined as time between first and last prescription plus 90 days (assumed to be the average length of prescription).
  3. b Classified according to Summary Staging classification with the TNM grouping translated as localized (TNM: T1–4, N0, M0), regional (TNM: T1–4, N1–3, M0), distant (TNM: T1–4, N1–3, M1), or unknown/missing.
  4. c Computed using the Charlson Comorbidity Index (CCI) score categorized into low (0), medium (1–2), or high (3+).