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Table 2 PFAA profiles of controls and lung cancer patients

From: The significance and robustness of a plasma free amino acid (PFAA) profile-based multiplex function for detecting lung cancer

A. Concentration
Amino acids P1 C1 P2 C2
  Mean SD Mean SD AUCa   Mean SD Mean SD AUCa pb
Thr 115.8 30.8 118.5 23.6 0.453   122.6 32.0 121.8 25.8 0.483  
Ser 107.8 20.8 108.8 18.1 0.472   110.7 20.1 106.7 17.4 0.560  
Asn 42.6 7.3 45.2 6.5 0.383 p<0.001 47.9 11.2 46.1 6.5 0.533  
Gln 547.4 71.4 586.9 64.2 0.347 p<0.001 577.5 84.1 587.1 61.5 0.470  
Pro 141.6 37.1 132.3 38.4 0.588 p<0.05 157.3 48.5 138.6 38.5 0.630 p<0.001
Gly 214.3 66.2 209.7 52.2 0.490   208.0 63.5 203.5 47.9 0.511  
Ala 324.2 84.5 343.1 74.8 0.428 <p0.05 366.5 99.8 353.5 69.7 0.550  
Cit 29.0 8.8 33.0 7.4 0.367 p<0.001 33.3 10.3 32.4 7.1 0.530  
Val 215.1 43.1 220.5 39.7 0.453   242.1 43.2 230.0 37.2 0.578 p<0.05
Met 24.2 5.4 25.8 4.6 0.388 p<0.01 26.9 7.2 26.8 4.1 0.489  
Ile 64.7 16.2 60.8 14.4 0.563   73.9 14.0 64.4 13.1 0.689 p<0.001
Leu 117.6 25.3 118.8 23.8 0.484   135.2 26.3 125.2 21.3 0.610 p<0.01
Tyr 65.9 15.0 65.2 12.5 0.503   71.9 15.9 67.3 10.9 0.579 p<0.05
Phe 59.5 9.9 59.6 9.4 0.496   66.5 12.8 61.3 7.9 0.625 p<0.001
His 69.7 12.5 80.2 9.5 0.255 p<0.001 74.1 15.8 81.2 9.4 0.383 p<0.001
Trp 51.3 11.0 57.0 8.8 0.338 p<0.004 56.4 13.4 59.6 8.9 0.432  
Orn 55.2 13.2 51.7 12.6 0.581 p<0.05 61.7 16.4 51.7 10.4 0.696 p<0.001
Lys 183.9 32.7 189.1 30.4 0.450   195.7 37.7 191.6 27.7 0.535  
Arg 93.1 20.7 95.1 16.8 0.460   100.4 24.7 96.4 15.1 0.551  
B. Ratio
Thr 4.556 0.887 4.544 0.706 0.488   4.460 0.749 4.590 0.781 0.445  
Ser 4.301 0.765 4.200 0.669 0.528   4.080 0.601 4.044 0.617 0.521  
Asn 1.692 0.218 1.740 0.197 0.408 p<0.01 1.749 0.235 1.742 0.194 0.494  
Gln 21.800 2.097 22.661 2.233 0.383 p<0.001 21.276 2.079 22.253 2.053 0.364 p<0.001
Pro 5.599 1.246 5.049 1.225 0.654 p<0.001 5.756 1.504 5.213 1.211 0.622 p<0.001
Gly 8.543 2.566 8.102 1.994 0.542   7.608 1.872 7.703 1.734 0.477  
Ala 12.715 2.141 13.123 2.156 0.459   13.253 2.380 13.321 2.092 0.499  
Cit 1.150 0.328 1.278 0.288 0.378 p<0.001 1.211 0.311 1.229 0.263 0.469  
Val 8.530 1.294 8.454 1.109 0.510   8.925 1.267 8.696 1.198 0.563  
Met 0.955 0.128 0.990 0.115 0.407 p<0.01 0.979 0.152 1.011 0.108 0.424 p<0.05
Ile 2.558 0.519 2.321 0.405 0.631 p<0.001 2.727 0.441 2.427 0.415 0.698 p<0.001
Leu 4.657 0.760 4.547 0.643 0.551   4.986 0.795 4.731 0.671 0.607 p<0.01
Tyr 2.616 0.495 2.503 0.368 0.560   2.644 0.455 2.543 0.335 0.567  
Phe 2.374 0.370 2.295 0.291 0.557   2.470 0.492 2.322 0.272 0.572 p<0.05
His 2.769 0.395 3.091 0.291 0.245 p<0.001 2.702 0.355 3.074 0.295 0.213 p<0.001
Trp 2.034 0.348 2.197 0.301 0.351 p<0.001 2.057 0.373 2.260 0.313 0.338 p<0.001
Orn 2.195 0.482 1.984 0.413 0.631 p<0.001 2.298 0.674 1.955 0.353 0.662 p<0.001
Lys 7.278 0.809 7.265 0.834 0.507   7.169 0.760 7.241 0.824 0.485  
Arg 3.680 0.568 3.657 0.525 0.519   3.650 0.550 3.645 0.473 0.494  
  1. a: AUC indicates AUC of the ROC curve.
  2. b: p value derived from the Mann–Whitney U-test.
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