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Table 2 Dose-limiting toxicities per dose level

From: Prospective, open, multi-centre phase I/II trial to assess safety and efficacy of neoadjuvant radiochemotherapy with docetaxel and oxaliplatin in patients with adenocarcinoma of the oesophagogastric junction

  Dose level  
  1 2 3 Total
Number of patients 4 (100%) 13 (100%) 7 (100%) 24 (100%)
Any DLTs?     
  No 3 (75%) 12 (92%) 2 (29%) 17 (71%)
  Yes 1 (25%) 1 (8%) 5 (71%) 7 (29%)
If yes:     
CTC-Grade III IV III IV III IV  
Non-haematological toxicity grade ≥ 3:        6 (25%)
 - Dehydration, syncope 1       
 - Heartburn/dyspepsia       1  
 - Fatigue      2   
 - Diarrhea      1   
 - Infection      1   
Haematological toxicity:        1 (4%)
 - Thrombocytpenia     1    
  1. DLT, dose limiting toxicity.