Model proposing different mechanisms of miR-200c regulatory activity on TUBB3 mRNA in ovarian cancer. When HuR is confined in the nucleus (HuR N), miR-200c behaves as a repressor, mediating TUBB3 mRNA decay (right panel). The resulting low levels of TUBB3 protein expression is linked to a good response to chemotherapy and a favorable outcome. On the contrary, if HuR is expressed in the cytoplasm (HuR C), the interaction with miR-200c-RISC on TUBB3 mRNA induces specific pickup of TUBB3 gene into ribosomes and enhancement of mRNA stability. This will yield up-regulation of TUBB3 protein, drug-resistance and early relapse with a poor outcome.