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Table 1 Prognostic indexes parameters

From: Comparative performances of prognostic indexes for breast cancer patients presenting with brain metastases

A: Clinical parameters used for 5 prognostic indexes (RPA, GPA, BS-BM, Breast RPA, and Breast GPA).
RPA
Class 1 Age <65 y, KPS ≥ 70, controlled primary tumor, no extracranial metastases
Class 2 All patients not in Class I or III
Class 3 KPS < 70
GPA
    0 0,5 1
Age    > 60 50-59 <50
KPS    <70 70-80 90-100
Number of BM    > 3 2-3 1
Extracranial metastases    Yes - No
BS-BM
     0 1
KPS     50-70 80-100
Control of primary tumor     No Yes
Extracranial metastases     Yes No
Breast RPA
Class 1 1–2 brain metastases and extracranial disease absent or controlled and KPS 100
Class 2 All patients not in Class I or III
Class 3 Multiple brain metastases and KPS ≤ 60
Breast GPA
  0 0,5 1 1.5 2
Age ≥ 60 <60    
KPS ≤ 50 60 70-80 90-100  
Genetic subtype Basal   Luminal A HER2 Luminal B
B: Clinico-biological parameters used for the P1PS and Le Scodan’s prognostic indexes.
P1PS
   0   1  
Sites of metastases   0-2   >2  
Serum LDH   <ULN   >ULN  
Albumin, g/L   ≥35   <35  
Le Scodan Score
Class I HER2+ tumors treated with trastuzumab
Class II All patients not in Class I or III
Class III Tumors not treated with trastuzumab and: lymphopenia at BM diagnosis or KPS < 70 and ≥ 50 years old at BM diagnosis or KPS ≥ 70 and triple negative tumors
  1. RPA, Recursive Partitioning Analysis, GPA, Graded Partitioning Analysis, BS-BM, Basic Score for Brain Metastases, BM, Brain Metastases, P1PS, phase 1 prognostic score, KPS, Karnofsky Performance Status, BM, Brain Metastases, LDH, Lactate Dehydrogenase, ULN, Upper Limit of Normal.