Table 1 Prognostic indexes parameters
A: Clinical parameters used for 5 prognostic indexes (RPA, GPA, BS-BM, Breast RPA, and Breast GPA). | |||||
|---|---|---|---|---|---|
RPA | |||||
Class 1 | Age <65 y, KPS ≥ 70, controlled primary tumor, no extracranial metastases | ||||
Class 2 | All patients not in Class I or III | ||||
Class 3 | KPS < 70 | ||||
GPA | |||||
0 | 0,5 | 1 | |||
Age | > 60 | 50-59 | <50 | ||
KPS | <70 | 70-80 | 90-100 | ||
Number of BM | > 3 | 2-3 | 1 | ||
Extracranial metastases | Yes | - | No | ||
BS-BM | |||||
0 | 1 | ||||
KPS | 50-70 | 80-100 | |||
Control of primary tumor | No | Yes | |||
Extracranial metastases | Yes | No | |||
Breast RPA | |||||
Class 1 | 1–2 brain metastases and extracranial disease absent or controlled and KPS 100 | ||||
Class 2 | All patients not in Class I or III | ||||
Class 3 | Multiple brain metastases and KPS ≤ 60 | ||||
Breast GPA | |||||
0 | 0,5 | 1 | 1.5 | 2 | |
Age | ≥ 60 | <60 | |||
KPS | ≤ 50 | 60 | 70-80 | 90-100 | |
Genetic subtype | Basal | Luminal A | HER2 | Luminal B | |
B: Clinico-biological parameters used for the P1PS and Le Scodan’s prognostic indexes. | |||||
P1PS | |||||
0 | 1 | ||||
Sites of metastases | 0-2 | >2 | |||
Serum LDH | <ULN | >ULN | |||
Albumin, g/L | ≥35 | <35 | |||
Le Scodan Score | |||||
Class I | HER2+ tumors treated with trastuzumab | ||||
Class II | All patients not in Class I or III | ||||
Class III | Tumors not treated with trastuzumab and: lymphopenia at BM diagnosis or KPS < 70 and ≥ 50 years old at BM diagnosis or KPS ≥ 70 and triple negative tumors | ||||