Effect of Rac3 inhibition on vasculogenic mimicry on growth-factor-rich Matrigel. Cells were treated for 48 h with 10 nM siRNA (control or Rac3). (A) Cells were plated on Matrigel rich in growth factors and photographed 4 h after seeding; scale bar represents 100 μm. (B) Cumulative length (top) and intersections (bottom) of capillary tubes were counted. Mean ± S.E., N=3 independent experiments. *P<0.05.