Figure 5

Berberine exhibited higher toxicity towards HONE1 cells. MTT assays were performed on one non-neoplastic nasopharyngeal epithelial cell line (NP460), and three NPC cell lines (HK1, C666-1 and HONE1) for 24, 48 and 72 hr under the indicated doses of berberine (0, 50, 100, 200, 400 and 800 μM). For each time point, the growth rates of each untreated cell line were arbitrarily assigned as 100. Mean ± SD were calculated from triplicate of two independent experiments.