Factors | Cut-offsa | Univariate | Multivariate | ||||
---|---|---|---|---|---|---|---|
p value | Hazard ratio | 95% CI | p value | Hazard ratio | 95% CI | ||
IgG response | Positive vs. negative | <0.0001 | 0.19 | 0.101-0.355 | 0.001 | 0.272 | 0.125-0.592 |
ECOG performance status | 0 vs. 1 | <0.0001 | 0.073 | 0.031-0.174 | 0.004 | 0.179 | 0.056-0.569 |
CRP | Low (<3000 ng/mL) vs. high | 0.012 | 0.461 | 0.252-0.842 | 0.006 | 0.389 | 0.199-0.759 |
PSADT | Increase (2 times) vs. no | 0.018 | 0.477 | 0.258-0.881 | 0.004 | 0.357 | 0.176-0.725 |
PSA | Low (<30 ng/mL) vs. high | 0.004 | 0.407 | 0.221-0.749 | 0.008 | 0.361 | 0.171-0.762 |
Prior chemotherapy | Untreated vs. treated | 0.037 | 0.536 | 0.298-0.962 | 0.329 | 0.695 | 0.335-1.445 |
T-cell response | Positive vs. negative | 0.039 | 0.51 | 0.269-0.967 | 0.273 | 0.679 | 0.340-1.357 |
>50% PSA decline | Positive vs. negative | 0.046 | 0.387 | 0.152-0.984 | 0.553 | 0.733 | 0.263-2.042 |
Number of lymphocytes | High (>1300/μL) vs. low | 0.054 | 0.562 | 0.313-1.009 | - | - | - |
IL6 | Low (<2.4 pg/mL) vs. high | 0.057 | 0.491 | 0.236-1.021 | - | - | - |
Pts. age | Low (<69 years) vs. high | 0.186 | 0.666 | 0.364-1.218 | - | - | - |
Gleason score | Low (<8) vs. high | 0.623 | 1.162 | 0.637-2.128 | - | - | - |
SAA | Low (<8 μg/mL) vs. high | 0.709 | 0.875 | 0.433-1.767 | - | - | - |