Skip to main content

Table 2 Grade 3 and 4 adverse events: NCI CTC v.3

From: Bifractionated CPT-11 with LV5FU2 infusion (FOLFIRI-3) in combination with bevacizumab: clinical outcomes in first-line metastatic colorectal cancers according to plasma angiopoietin-2 levels

  Induction chemotherapy Maintenance chemotherapy
(N = 61) (N = 41)
Adverse events No. of patients % No. of patients %
Nausea 1 2 0 -
Vomiting 1 2 0 -
Diarrhea 9 15 2 5
Mucositis 0 - 0 -
Fatigue 6 10 1 2
Platelet count decreased 0 - 0 -
Anemia 0 - 0 -
White blood cell decreased 3 5 0 -
Neutropenia 8 13 0 -
(2 grade IV)
Febrile neutropenia 1 2 0 -
Hypertension 3 5 1 2
Hemorrhage 1 2 0 -
Thromboembolic event 0 - 1* 2
Palmar-plantar syndrome 0 - 6 15
  1. *One catheter related deep vein thrombosis.
  2. Grade IV toxicity: the only grade IV toxicity observed was neutropenia.