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Table 2 Associations of TP53 SNPs with lung cancer risk in Taiyuan lung cancer study in total study population

From: TP53 genetic polymorphisms, interactions with lifestyle factors and lung cancer risk: a case control study in a Chinese population

SNP Genotype Cases Controls Crude OR (95% CI) Adjusted OR* (95% CI)
   N % N %   
TP53 rs2078486   355   448    
  CC 186 52.4 250 55.8 1 1
  TC 136 38.3 167 37.3 1.10 (0.82, 1.47) 1.20 (0.88, 1.64)
  TT 33 9.3 31 6.9 1.43 (0.85, 2.42) 1.30 (0.75, 2.25)
Dominant model Any T vs. CC 169 47.6 198 44.2 1.15 (0.87, 1.52) 1.22 (0.91, 1.63)
Recessive model TT vs. Any C 33 9.3 31 6.9 1.38 (0.83, 2.30) 1.20 (0.70, 2.06)
Allele OR T vs. C      1.15 (0.93, 1.43) 1.17 (0.93, 1.46)
TP53 rs1042522   363   446    
  GG 118 32.5 161 36.1 1 1
  CG 146 40.2 196 43.9 1.02 (0.74, 1.40) 1.07 (0.77, 1.50)
  CC 99 27.3 89 20.0 1.52 (1.05, 2.20) 1.63 (1.10, 2.41)
Dominant model Any C vs. GG 245 67.5 285 63.9 1.17 (0.88, 1.57) 1.24 (0.92, 1.69)
Recessive model CC vs. Any G 99 27.3 89 20.0 1.50 (1.08, 2.09) 1.57 (1.11, 2.21)
Allele OR C vs. G      1.21 (1.01, 1.46) 1.26 (1.04, 1.53)
  1. *Adjusted for age, gender, education, pack years of smoking, alcohol drinking, tea drinking and average income 10 years ago.
  2. Significant results were highlighted in bold.