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Figure 1 | BMC Cancer

Figure 1

From: Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo

Figure 1

Impact of gemcitabine and MK-8776 on cell cycle perturbation of MDA-MB-231 cells. A. Cells were incubated with 0 – 50 nmol/L gemcitabine for 24 h without (left) or with (right) 1 μmol/L MK-8776. The drugs were then removed and cells incubated for an additional 24 or 48 h. Cells were then analyzed for DNA content by flow cytometry. B. Similar to A except cells were incubated with gemcitabine for only the first 6 h, while MK-8776 was added only from 18–24 h.

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BMC Cancer

ISSN: 1471-2407

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