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Table 4 Promoter methylation frequencies of SFRP2 , WIF-1 , DKK3 and SOX17 in relation with chromosome 5q loss

From: Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas

  Nonpolypoid 5q loss Nonpolypoid no 5q loss p-value Polypoid 5q loss Polypoid no 5q loss p-value All adenomas 5q loss All adenomas no 5q loss p-value
SFRP2 75% (6/8) 97% (28/29) 0.1** 100% (1/1) 90% (26/29) 1** 78% (7/9) 93% (54/58) 0.2**
WIF-1 50% (4/8) 60% (18/30) 0.7** 100% (1/1) 92% (22/24) 1** 56% (5/9) 74% (40/54) 0.3**
DKK3 63% (5/8) 82% (23/28) 0.3** 100% (1/1) 96% (23/24) 1** 67% (6/9) 89% (46/52) 0.1**
SOX17 88% (7/8) 97% (28/29) 0.4** 100% (1/1) 100% (24/24) - 89% (8/9) 98% (52/53) 0.3**
All four combined 25% (2/8) 43% (12/28) 0.4** 100% (1/1) 66% (19/24) 1** 33% (3/9) 60% (31/52) 0.2**
  1. Results are shown for polypoid adenomas, nonpolypoid adenomas and all adenomas together, divided into samples that had a chromosome 5q loss (locus of APC) or samples that had no chromosome 5q loss.
  2. All four combined; is considered positive if all four genes showed methylation. **Fisher exact based p-value.