Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas

BMC Cancer

Table 4 Promoter methylation frequencies of SFRP2 , WIF-1 , DKK3 and SOX17 in relation with chromosome 5q loss

	Nonpolypoid 5q loss	Nonpolypoid no 5q loss	p-value	Polypoid 5q loss	Polypoid no 5q loss	p-value	All adenomas 5q loss	All adenomas no 5q loss	p-value
SFRP2	75% (6/8)	97% (28/29)	0.1**	100% (1/1)	90% (26/29)	1**	78% (7/9)	93% (54/58)	0.2**
WIF-1	50% (4/8)	60% (18/30)	0.7**	100% (1/1)	92% (22/24)	1**	56% (5/9)	74% (40/54)	0.3**
DKK3	63% (5/8)	82% (23/28)	0.3**	100% (1/1)	96% (23/24)	1**	67% (6/9)	89% (46/52)	0.1**
SOX17	88% (7/8)	97% (28/29)	0.4**	100% (1/1)	100% (24/24)	-	89% (8/9)	98% (52/53)	0.3**
All four combined	25% (2/8)	43% (12/28)	0.4**	100% (1/1)	66% (19/24)	1**	33% (3/9)	60% (31/52)	0.2**

Results are shown for polypoid adenomas, nonpolypoid adenomas and all adenomas together, divided into samples that had a chromosome 5q loss (locus of APC) or samples that had no chromosome 5q loss.
All four combined; is considered positive if all four genes showed methylation. **Fisher exact based p-value.

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