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Table 2 Promoter methylation frequencies of SFRP2 , WIF-1 , DKK3 and SOX17 in relation to location

From: Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas

  Left nonpolypoid adenomas Right nonpolypoid adenomas p-value Left polypoid adenomas Right polypoid adenomas p-value All adenomas left All adenomas right p-value
SFRP2 79% (11/14) 100% (29/29) 0.3** 93% (37/40) 100% (4/4) 1** 89% (48/54) 100% (33/33) 0.08**
WIF-1 69% (9/13) 52% (15/29) 0.3** 86% (31/36) 100% (3/3) 1** 82% (40/49) 56% (18/32) 0.013*
DKK3 64% (9/14) 82% (23/28) 0.3** 97% (35/36) 100% (3/3) 1** 88% (44/50) 84% (26/31) 0.7**
SOX17 86% (12/14) 97% (28/29) 0.2** 100% (36/36) 100% (3/3) - 96% (48/50) 97% (31/32) 1**
All four combined 38% (5/13) 41% (11/27) 0.9* 78% (28/36) 100% (3/3) 1** 67% (33/49) 47% (14/30) 0.07**
  1. Results are shown for polypoid adenomas, nonpolypoid adenomas and all adenomas together, divided into samples that were distal (left) or proximal (right).
  2. All four combined; is considered positive if all four genes showed methylation. *chi-square based p-value **Fisher exact based p-value.