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Table 1 Clinicopathologic features of patients with human papillomavirus positive oropharyngeal SCC, overall and by PIK3CA mutational status

From: PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma

Feature Total1, n = 75 PIK3CAwild type PIK3CAmutant Notes
n = 51 n = 23
Men/women 64/11 43/8 20/3 n.s.
Average age, years (range) 56 (34–78) 56 55.3 n.s.
Smoking2 Never 22 15 7 n.s.
Ever 40 26 14
Site3 BOT 31 24 7 n.s.
Tonsil 43 27 15
pT4 1 34 23 11 n.s.
2 25 17 8
3 7 4 3
4 5 4 1
pN6 0 2 2 0 n.s.
1 16 11 5
2 51 35 15
3 5 3 2
Resection Margins5 Positive 10 7 3 n.s.
Negative 54 36 18
Clinical Stage6 I 1 1 0 n.s.
III 15 10 4
IV 58 40 18
Therapy7 RT 43 32 11 n.s.
CRT 21 14 7
Non-keratinizing 52 35 17 n.s.
Mixed 23 17 5
Deceased of disease 14 9 5  
  1. 1For one patient with HRAS mutation PIK3CA status was indeterminate. The clinicopathologic features of the case with indeterminate PIK3CA status are not presented in the columns 3 and 4 of the Table.
  2. 2Smoking history was not available for 13 patients.
  3. 3The oropharyngeal sub-site for one case was unknown.
  4. 4pT was unknown for 4 cases with biopsies only.
  5. 5Margin status was not assessed in 11 cases (biopsies, fragmented specimens).
  6. 6pN and clinical stage were unknown for 1 patient.
  7. 7Seven patients received no postoperative therapy; for 4 patients these data were not available.
  8. BOT base of tongue, RT radiotherapy, CT chemotherapy, CRT chemoradiotherapy, mixed keratinizing and non-keratinizing, n.s. not statistically significant.