Skip to main content

Table 1 Clinicopathologic features of patients with human papillomavirus positive oropharyngeal SCC, overall and by PIK3CA mutational status

From: PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma

Feature

Total1, n = 75

PIK3CAwild type

PIK3CAmutant

Notes

n = 51

n = 23

Men/women

64/11

43/8

20/3

n.s.

Average age, years (range)

56 (34–78)

56

55.3

n.s.

Smoking2

Never

22

15

7

n.s.

Ever

40

26

14

Site3

BOT

31

24

7

n.s.

Tonsil

43

27

15

pT4

1

34

23

11

n.s.

2

25

17

8

3

7

4

3

4

5

4

1

pN6

0

2

2

0

n.s.

1

16

11

5

2

51

35

15

3

5

3

2

Resection Margins5

Positive

10

7

3

n.s.

Negative

54

36

18

Clinical Stage6

I

1

1

0

n.s.

III

15

10

4

IV

58

40

18

Therapy7

RT

43

32

11

n.s.

CRT

21

14

7

Non-keratinizing

52

35

17

n.s.

Mixed

23

17

5

Deceased of disease

14

9

5

 
  1. 1For one patient with HRAS mutation PIK3CA status was indeterminate. The clinicopathologic features of the case with indeterminate PIK3CA status are not presented in the columns 3 and 4 of the Table.
  2. 2Smoking history was not available for 13 patients.
  3. 3The oropharyngeal sub-site for one case was unknown.
  4. 4pT was unknown for 4 cases with biopsies only.
  5. 5Margin status was not assessed in 11 cases (biopsies, fragmented specimens).
  6. 6pN and clinical stage were unknown for 1 patient.
  7. 7Seven patients received no postoperative therapy; for 4 patients these data were not available.
  8. BOT base of tongue, RT radiotherapy, CT chemotherapy, CRT chemoradiotherapy, mixed keratinizing and non-keratinizing, n.s. not statistically significant.
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us