|
Symptom
|
Sample size
|
Age group
|
Mean score
|
Distress ratings† (%)
|
Unadjusted values
|
Adjusted values
|
|---|
|
Older age
|
Older age
|
|---|
|
0
|
1
|
2
|
3
|
4
|
OR
|
CI
|
p-value
|
OR
|
CI
|
p-value
|
|---|
|
Difficulty concentrating
|
147
|
<60
|
1.52
|
17.7
|
38.1
|
22.4
|
18.4
|
3.4
|
.71
|
.45-1.10
|
.124
|
.82
|
.50-1.34
|
.424
|
|
116
|
≥60
|
1.33
|
25.0
|
37.9
|
21.6
|
10.3
|
5.2
|
|
Pain
|
192
|
<60
|
2.01
|
6.3
|
32.3
|
29.2
|
19.3
|
13.0
|
.63
|
.43-.90
|
.012
|
.65
|
.43-.98
|
.041
|
|
183
|
≥60
|
1.69
|
15.8
|
32.2
|
26.2
|
18.0
|
7.7
|
|
Lack of energy
|
212
|
<60
|
2.04
|
8.5
|
26.4
|
30.2
|
22.6
|
12.3
|
.54
|
.39-.77
|
<.001
|
.57
|
.39-.83
|
.004
|
|
220
|
≥60
|
1.64
|
20.5
|
30.5
|
22.3
|
18.6
|
8.2
|
|
Cough
|
103
|
<60
|
1.39
|
29.1
|
28.2
|
24.3
|
11.7
|
6.8
|
.60
|
.37-.97
|
.037
|
.52
|
.29-.91
|
.022
|
|
112
|
≥60
|
1.07
|
42.9
|
25.0
|
19.6
|
7.1
|
5.4
|
|
Feeling nervous
|
102
|
<60
|
1.70
|
10.8
|
38.2
|
26.5
|
19.6
|
4.9
|
.51
|
.30-.87
|
.013
|
.57
|
.30-1.06
|
.075
|
|
85
|
≥60
|
1.33
|
23.5
|
40.0
|
22.4
|
8.2
|
5.9
|
|
Dry mouth
|
111
|
<60
|
1.45
|
22.5
|
37.8
|
20.7
|
9.9
|
9.0
|
.50
|
.32-.80
|
.003
|
.47
|
.29-.76
|
.002
|
|
133
|
≥60
|
1.05
|
42.1
|
29.3
|
15.8
|
7.5
|
5.3
|
|
Nausea
|
99
|
<60
|
1.84
|
12.1
|
32.3
|
29.3
|
12.1
|
14.1
|
.47
|
.27-.80
|
.006
|
.46
|
.25-.86
|
.015
|
|
81
|
≥60
|
1.37
|
33.3
|
29.6
|
13.6
|
13.6
|
9.9
|
|
Feeling drowsy
|
165
|
<60
|
1.39
|
21.2
|
39.4
|
23.0
|
12.1
|
4.2
|
.53
|
.36-.79
|
.002
|
.52
|
.34-.80
|
.003
|
|
167
|
≥60
|
1.07
|
40.1
|
31.7
|
13.8
|
9.6
|
4.8
|
|
Numbness/tingling in hands/feet
|
94
|
<60
|
1.40
|
21.3
|
39.4
|
20.2
|
16.0
|
3.2
|
.72
|
.43-1.21
|
.212
|
.84
|
.46-1.56
|
.586
|
|
91
|
≥60
|
1.25
|
33.0
|
33.0
|
16.5
|
11.0
|
6.6
|
|
Difficulty sleeping
|
166
|
<60
|
2.01
|
9.6
|
29.5
|
25.9
|
19.9
|
15.1
|
.61
|
.41-.92
|
.017
|
.54
|
.35-.86
|
.008
|
|
142
|
≥60
|
1.66
|
19.0
|
27.5
|
29.6
|
16.2
|
7.7
|
|
Feeling bloated
|
81
|
<60
|
1.85
|
16.0
|
24.7
|
27.2
|
22.2
|
9.9
|
.43
|
.23-.81
|
.008
|
.38
|
.18-.80
|
.011
|
|
56
|
≥60
|
1.30
|
19.6
|
42.9
|
26.8
|
8.9
|
1.8
|
|
Problems with urination
|
54
|
<60
|
1.57
|
24.1
|
25.9
|
25.9
|
16.7
|
7.4
|
1.21
|
.67-2.19
|
.530
|
.91
|
.47-1.76
|
.783
|
|
108
|
≥60
|
1.70
|
14.8
|
32.4
|
31.5
|
10.2
|
11.1
|
|
Vomiting
|
43
|
<60
|
1.63
|
23.3
|
32.6
|
16.3
|
14.0
|
14.0
|
.78
|
.34-1.79
|
.553
|
.58
|
.21-1.62
|
.298
|
|
30
|
≥60
|
1.43
|
33.3
|
20.0
|
26.7
|
10.0
|
10.0
|
|
Shortness of breath
|
97
|
<60
|
1.63
|
14.4
|
41.2
|
21.6
|
12.4
|
10.3
|
.79
|
.48-1.30
|
.347
|
.80
|
.46-1.39
|
.427
|
|
100
|
≥60
|
1.47
|
28.0
|
26.0
|
24.0
|
15.0
|
7.0
|
|
Diarrhea
|
54
|
<60
|
1.59
|
18.5
|
38.9
|
14.8
|
20.4
|
7.4
|
.69
|
.36-1.34
|
.274
|
.61
|
.28-1.31
|
.204
|
|
63
|
≥60
|
1.32
|
25.4
|
33.3
|
30.2
|
6.3
|
4.8
|
|
Feeling sad
|
137
|
<60
|
1.87
|
8.0
|
36.5
|
27.0
|
17.5
|
10.9
|
.47
|
.29-.77
|
.003
|
.49
|
.28-.85
|
.011
|
|
94
|
≥60
|
1.41
|
14.9
|
46.8
|
24.5
|
9.6
|
4.3
|
|
Sweats
|
117
|
<60
|
1.75
|
17.1
|
29.1
|
28.2
|
12.8
|
12.8
|
.49
|
.30-.80
|
.005
|
.56
|
.32-.98
|
.040
|
|
95
|
≥60
|
1.26
|
24.2
|
40.0
|
24.2
|
8.4
|
3.2
|
|
Worrying
|
151
|
<60
|
1.93
|
7.3
|
34.4
|
28.5
|
17.9
|
11.9
|
.45
|
.28-.72
|
.001
|
.57
|
.34-.96
|
.033
|
|
101
|
≥60
|
1.46
|
8.9
|
53.5
|
23.8
|
10.9
|
3.0
|
|
Problems with sexual interest
|
91
|
<60
|
2.08
|
22.0
|
19.8
|
15.4
|
14.3
|
28.6
|
.96
|
.55-1.66
|
.875
|
.89
|
.46-1.73
|
.731
|
|
69
|
≥60
|
2.03
|
18.8
|
20.3
|
24.6
|
11.6
|
24.6
|
|
Itching
|
88
|
<60
|
1.56
|
15.9
|
40.9
|
25.0
|
8.0
|
10.2
|
.82
|
.46-1.45
|
.497
|
1.04
|
.55-1.95
|
.908
|
|
69
|
≥60
|
1.42
|
24.6
|
31.9
|
27.5
|
8.7
|
7.2
|
|
Lack of appetite
|
99
|
<60
|
1.38
|
27.3
|
31.3
|
24.2
|
10.1
|
7.1
|
.85
|
.51-1.41
|
.529
|
.85
|
.48-1.51
|
.589
|
|
96
|
≥60
|
1.28
|
32.3
|
29.2
|
21.9
|
11.5
|
5.2
|
|
Dizziness
|
69
|
<60
|
1.32
|
23.2
|
37.7
|
26.1
|
10.1
|
2.9
|
.84
|
.45-1.56
|
.572
|
.62
|
.30-1.29
|
.202
|
|
63
|
≥60
|
1.25
|
23.8
|
46.0
|
15.9
|
9.5
|
4.8
|
|
Difficulty swallowing
|
40
|
<60
|
1.65
|
10.0
|
40.0
|
30.0
|
15.0
|
5.0
|
.96
|
.44-2.09
|
.924
|
.85
|
.35-2.06
|
.724
|
|
43
|
≥60
|
1.63
|
20.9
|
27.9
|
23.3
|
23.3
|
4.7
|
|
Feeling irritable
|
135
|
<60
|
1.49
|
21.5
|
34.8
|
24.4
|
11.9
|
7.4
|
.79
|
.49-1.27
|
.335
|
.82
|
.48-1.42
|
.485
|
|
96
|
≥60
|
1.31
|
18.8
|
47.9
|
17.7
|
14.6
|
1.0
|
|
Mouth sores
|
36
|
<60
|
1.67
|
22.2
|
30.6
|
19.4
|
13.9
|
13.9
|
.46
|
.20-1.09
|
.079
|
.41
|
.16-1.03
|
.058
|
|
35
|
≥60
|
1.11
|
31.4
|
42.9
|
11.4
|
11.4
|
2.9
|
|
Change in way food tastes
|
78
|
<60
|
1.69
|
17.9
|
32.1
|
25.6
|
11.5
|
12.8
|
.47
|
.27-.81
|
.007
|
.57
|
.31-1.05
|
.072
|
|
89
|
≥60
|
1.18
|
32.6
|
36.0
|
14.6
|
14.6
|
2.2
|
|
Weight loss
|
61
|
<60
|
1.05
|
45.9
|
26.2
|
13.1
|
6.6
|
8.2
|
.67
|
.35-1.29
|
.232
|
.51
|
.24-1.09
|
.082
|
|
68
|
≥60
|
0.78
|
54.4
|
26.5
|
8.8
|
7.4
|
2.9
|
|
Hair loss
|
61
|
<60
|
1.74
|
19.7
|
29.5
|
21.3
|
16.4
|
13.1
|
.50
|
.26-.97
|
.041
|
.48
|
.23-.99
|
.048
|
|
55
|
≥60
|
1.29
|
43.6
|
20.0
|
9.1
|
18.2
|
9.1
|
|
Constipation
|
87
|
<60
|
2.09
|
13.8
|
23.0
|
25.3
|
16.1
|
21.8
|
.68
|
.41-1.14
|
.145
|
.74
|
.42-1.29
|
.285
|
|
95
|
≥60
|
1.80
|
23.2
|
25.3
|
15.8
|
20.0
|
15.8
|
|
Swelling of arms or legs
|
42
|
<60
|
1.64
|
28.6
|
23.8
|
19.0
|
11.9
|
16.7
|
.96
|
.46-2.01
|
.913
|
1.11
|
.46-2.67
|
.819
|
|
48
|
≥60
|
1.58
|
27.1
|
25.0
|
18.8
|
20.8
|
8.3
|
|
I don’t look like myself
|
91
|
<60
|
1.89
|
11.0
|
36.3
|
19.8
|
18.7
|
14.3
|
.32
|
.17-.58
|
<.001
|
.30
|
.15-.58
|
<.001
|
|
64
|
≥60
|
1.14
|
34.4
|
34.4
|
17.2
|
10.9
|
3.1
|
|
Changes in skin
|
99
|
<60
|
1.76
|
11.1
|
36.4
|
29.3
|
12.1
|
11.1
|
.41
|
.23-.76
|
.004
|
.51
|
.27-.98
|
.043
|
|
62
|
≥60
|
1.26
|
38.7
|
24.2
|
17.7
|
11.3
|
8.1
|
- Abbreviations: CI, confidence interval; OR, odds ratio.
- †Distress ratings = not at all (0), a little bit (1), somewhat (2), quite a bit (4), very much (5).
