Symptom
|
Sample size
|
Age group
|
Mean score
|
Severity ratings† (%)
|
Unadjusted values
|
Adjusted values
|
---|
Older age
|
Older age
|
---|
1
|
2
|
3
|
4
|
OR
|
CI
|
p-value
|
OR
|
CI
|
p-value
|
---|
Difficulty concentrating
|
149
|
<60
|
1.67
|
44.3
|
45.0
|
10.1
|
0.7
|
.80
|
.50-1.28
|
.353
|
.78
|
.46-1.32
|
.354
|
115
|
≥60
|
1.61
|
50.4
|
40.0
|
7.8
|
1.7
|
Pain
|
192
|
<60
|
2.08
|
24.5
|
47.9
|
22.9
|
4.7
|
1.08
|
.74-1.58
|
.674
|
.97
|
.64-1.49
|
.898
|
181
|
≥60
|
2.12
|
24.3
|
45.3
|
24.3
|
6.1
|
Lack of energy
|
214
|
<60
|
2.15
|
15.4
|
57.5
|
23.8
|
3.3
|
.91
|
.64-1.31
|
.622
|
.81
|
.55-1.21
|
.311
|
217
|
≥60
|
2.13
|
21.7
|
49.8
|
22.1
|
6.5
|
Cough
|
102
|
<60
|
1.74
|
46.1
|
36.3
|
15.7
|
2.0
|
1.04
|
.63-1.73
|
.870
|
.86
|
.47-1.55
|
.609
|
110
|
≥60
|
1.75
|
44.5
|
38.2
|
14.5
|
2.7
|
Feeling nervous
|
103
|
<60
|
1.83
|
35.9
|
47.6
|
13.6
|
2.9
|
.81
|
.47-1.40
|
.452
|
.81
|
.42-1.54
|
.514
|
85
|
≥60
|
1.78
|
40.0
|
48.2
|
5.9
|
5.9
|
Dry mouth
|
110
|
<60
|
2.06
|
28.2
|
41.8
|
25.5
|
4.5
|
.64
|
.40-1.03
|
.068
|
.54
|
.32-.91
|
.020
|
131
|
≥60
|
1.89
|
38.2
|
41.2
|
14.5
|
6.1
|
Nausea
|
99
|
<60
|
1.99
|
31.3
|
42.4
|
22.2
|
4.0
|
.64
|
.37-1.10
|
.107
|
.62
|
.33-1.14
|
.123
|
81
|
≥60
|
1.80
|
43.2
|
37.0
|
16.0
|
3.7
|
Feeling drowsy
|
167
|
<60
|
1.95
|
24.6
|
58.1
|
15.6
|
1.8
|
.68
|
.45-1.03
|
.068
|
.61
|
.38-.96
|
.033
|
169
|
≥60
|
1.82
|
32.5
|
55.0
|
10.7
|
1.8
|
Numbness/tingling in hands/feet
|
94
|
<60
|
1.85
|
36.2
|
45.7
|
14.9
|
3.2
|
.90
|
.53-1.55
|
.710
|
.79
|
.42-1.52
|
.484
|
91
|
≥60
|
1.85
|
41.8
|
38.5
|
13.2
|
6.6
|
Difficulty sleeping
|
168
|
<60
|
2.23
|
14.9
|
54.8
|
23.2
|
7.1
|
.87
|
.56-1.33
|
.512
|
.67
|
.42-1.09
|
.108
|
141
|
≥60
|
2.16
|
17.0
|
54.6
|
24.1
|
4.3
|
Feeling bloated
|
82
|
<60
|
1.91
|
30.5
|
51.2
|
14.6
|
3.7
|
.77
|
.40-1.47
|
.429
|
.77
|
.36-1.66
|
.510
|
55
|
≥60
|
1.82
|
36.4
|
49.1
|
10.9
|
3.6
|
Problems with urination
|
54
|
<60
|
1.96
|
33.3
|
42.6
|
18.5
|
5.6
|
1.14
|
.61-2.11
|
.685
|
1.10
|
.56-2.18
|
.777
|
110
|
≥60
|
2.01
|
26.4
|
52.7
|
14.5
|
6.4
|
Vomiting
|
43
|
<60
|
1.91
|
41.9
|
32.6
|
18.6
|
7.0
|
.90
|
.38-2.14
|
.811
|
.51
|
.17-1.54
|
.232
|
29
|
≥60
|
1.79
|
37.9
|
44.8
|
17.2
|
0.0
|
Shortness of breath
|
97
|
<60
|
1.78
|
40.2
|
45.4
|
10.3
|
4.1
|
1.52
|
.90-2.58
|
.116
|
1.27
|
.71-2.29
|
.423
|
99
|
≥60
|
2.00
|
33.3
|
42.4
|
15.2
|
9.1
|
Diarrhea
|
54
|
<60
|
1.93
|
24.1
|
61.1
|
13.0
|
1.9
|
.67
|
.33-1.35
|
.263
|
.62
|
.27-1.42
|
.258
|
63
|
≥60
|
1.81
|
36.5
|
49.2
|
11.1
|
3.2
|
Feeling sad
|
137
|
<60
|
1.99
|
30.7
|
43.8
|
21.2
|
4.4
|
.43
|
.26-.72
|
.001
|
.43
|
.24-.76
|
.003
|
93
|
≥60
|
1.66
|
46.2
|
46.2
|
3.2
|
4.3
|
Sweats
|
117
|
<60
|
2.14
|
23.9
|
44.4
|
25.6
|
6.0
|
.54
|
.33-.91
|
.019
|
.56
|
.31-.997
|
.049
|
95
|
≥60
|
1.86
|
34.7
|
46.3
|
16.8
|
2.1
|
Worrying
|
152
|
<60
|
2.10
|
20.4
|
58.6
|
11.8
|
9.2
|
.43
|
.26-.72
|
.001
|
.52
|
.30-.90
|
.020
|
101
|
≥60
|
1.77
|
38.6
|
49.5
|
7.9
|
4.0
|
Problems with sexual interest
|
92
|
<60
|
2.50
|
22.8
|
31.5
|
18.5
|
27.2
|
1.43
|
.82-2.52
|
.212
|
1.12
|
.57-2.19
|
.745
|
69
|
≥60
|
2.72
|
18.8
|
24.6
|
21.7
|
34.8
|
Itching
|
88
|
<60
|
1.86
|
38.6
|
43.2
|
11.4
|
6.8
|
.84
|
.46-1.52
|
.562
|
.89
|
.46-1.75
|
.745
|
69
|
≥60
|
1.78
|
42.0
|
43.5
|
8.7
|
5.8
|
Lack of appetite
|
99
|
<60
|
2.00
|
27.3
|
49.5
|
19.2
|
4.0
|
.96
|
.57-1.64
|
.886
|
.77
|
.42-1.43
|
.409
|
94
|
≥60
|
2.00
|
27.7
|
51.1
|
14.9
|
6.4
|
Dizziness
|
69
|
<60
|
1.54
|
55.1
|
37.7
|
5.8
|
1.4
|
.84
|
.43-1.65
|
.615
|
.61
|
.27-1.39
|
.241
|
64
|
≥60
|
1.48
|
59.4
|
34.4
|
4.7
|
1.6
|
Difficulty swallowing
|
40
|
<60
|
2.03
|
27.5
|
45.0
|
25.0
|
2.5
|
.53
|
.23-1.21
|
.133
|
.39
|
.14-1.10
|
.074
|
43
|
≥60
|
1.79
|
37.2
|
51.2
|
7.0
|
4.7
|
Feeling irritable
|
135
|
<60
|
1.77
|
40.7
|
42.2
|
16.3
|
0.7
|
.82
|
.50-1.34
|
.425
|
.65
|
.37-1.15
|
.142
|
98
|
≥60
|
1.68
|
41.8
|
49.0
|
8.2
|
1.0
|
Mouth sores
|
37
|
<60
|
1.86
|
43.2
|
35.1
|
13.5
|
8.1
|
.55
|
.23-1.34
|
.188
|
.52
|
.19-1.43
|
.205
|
35
|
≥60
|
1.60
|
60.0
|
22.9
|
14.3
|
2.9
|
Change in way food tastes
|
79
|
<60
|
2.06
|
27.8
|
48.1
|
13.9
|
10.1
|
.81
|
.46-1.43
|
.476
|
1.05
|
.57-1.93
|
.883
|
91
|
≥60
|
1.96
|
31.9
|
47.3
|
14.3
|
6.6
|
Weight loss
|
60
|
<60
|
1.67
|
48.3
|
38.3
|
11.7
|
1.7
|
.87
|
.45-1.69
|
.674
|
.60
|
.28-1.30
|
.196
|
67
|
≥60
|
1.63
|
52.2
|
35.8
|
9.0
|
3.0
|
Hair loss
|
61
|
<60
|
2.38
|
27.9
|
26.2
|
26.2
|
19.7
|
.97
|
.50-1.88
|
.921
|
.77
|
.36-1.61
|
.482
|
52
|
≥60
|
2.37
|
32.7
|
23.1
|
19.2
|
25.0
|
Constipation
|
87
|
<60
|
2.38
|
17.2
|
40.2
|
29.9
|
12.6
|
.67
|
.39-1.14
|
.139
|
.74
|
.42-1.32
|
.308
|
96
|
≥60
|
2.19
|
24.0
|
43.8
|
21.9
|
10.4
|
Swelling of arms or legs
|
42
|
<60
|
2.19
|
33.3
|
31.0
|
19.0
|
16.7
|
.92
|
.43-1.98
|
.837
|
.86
|
.36-2.04
|
.734
|
47
|
≥60
|
2.09
|
25.5
|
44.7
|
25.5
|
4.3
|
I don’t look like myself
|
91
|
<60
|
2.14
|
24.2
|
47.3
|
18.7
|
9.9
|
.52
|
.28-.95
|
.033
|
.49
|
.25-.96
|
.037
|
62
|
≥60
|
1.82
|
43.5
|
32.3
|
22.6
|
1.6
|
Changes in skin
|
99
|
<60
|
2.07
|
24.2
|
53.5
|
13.1
|
9.1
|
.63
|
.34-1.16
|
.140
|
.80
|
.41-1.56
|
.510
|
61
|
≥60
|
1.89
|
37.7
|
42.6
|
13.1
|
6.6
|
- Abbreviations: CI, confidence interval; OR, odds ratio.
- †Severity ratings = slight (1), moderate (2), severe (3), very severe (4).