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Table 2 Multivariate analysis using Cox proportional hazards model on DFS, including only patients with no missing values (N = 431)*

From: Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study

Parameter

ELISA

PLA

 

HR

95% Cl

P

HR

95% Cl

P

MMP-9:TIMP-1 complex

      

Q2 vs. Q1

1.08

0.65-1.80

0.771

0.91

0.56-1.49

0.712

Q3 vs. Q1

1.12

0.68-1.85

0.652

0.84

0.51-1.38

0.493

Q4 vs. Q1

1.06

0.64-1.77

0.812

0.76

0.46-1.27

0.294

Age

      

50-69 years vs. < 50 years

0.82

0.39-1.71

0.592

0.82

0.39-1.72

0.601

≥ 70 years vs. < 50 years

2.48

1.63-3.77

<0.0001

2.49

1.64-3.78

<0.0001

Menopausal status

      

Post- vs. premenopausal

1.14

0.58-2.27

0.705

1.19

0.60-2.36

0.618

Tumor size

      

>20 mm vs. 0–20 mm

1.25

0.85-1.82

0.254

1.24

0.85-1.81

0.261

Lymph node status

      

Positive vs. negative

1.22

0.84-1.77

0.301

1.26

0.87-1.84

0.22

Hormone receptor status

      

Positive vs. negative

0.47

0.30-0.75

0.002

0.48

0.30-0.76

0.002

Malignacy grade

      

Grade 2 + 3 vs. Grade 1

1.15

0.76-1.75

0.499

1.14

0.75-1.73

0.536

  1. *34 patients are excluded from the analysis due to missing values for one or more of the prognostic factors.
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