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Table 2 Multivariate analysis using Cox proportional hazards model on DFS, including only patients with no missing values (N = 431)*

From: Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study

Parameter ELISA PLA
  HR 95% Cl P HR 95% Cl P
MMP-9:TIMP-1 complex       
Q2 vs. Q1 1.08 0.65-1.80 0.771 0.91 0.56-1.49 0.712
Q3 vs. Q1 1.12 0.68-1.85 0.652 0.84 0.51-1.38 0.493
Q4 vs. Q1 1.06 0.64-1.77 0.812 0.76 0.46-1.27 0.294
Age       
50-69 years vs. < 50 years 0.82 0.39-1.71 0.592 0.82 0.39-1.72 0.601
≥ 70 years vs. < 50 years 2.48 1.63-3.77 <0.0001 2.49 1.64-3.78 <0.0001
Menopausal status       
Post- vs. premenopausal 1.14 0.58-2.27 0.705 1.19 0.60-2.36 0.618
Tumor size       
>20 mm vs. 0–20 mm 1.25 0.85-1.82 0.254 1.24 0.85-1.81 0.261
Lymph node status       
Positive vs. negative 1.22 0.84-1.77 0.301 1.26 0.87-1.84 0.22
Hormone receptor status       
Positive vs. negative 0.47 0.30-0.75 0.002 0.48 0.30-0.76 0.002
Malignacy grade       
Grade 2 + 3 vs. Grade 1 1.15 0.76-1.75 0.499 1.14 0.75-1.73 0.536
  1. *34 patients are excluded from the analysis due to missing values for one or more of the prognostic factors.