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Table 1 Patient, tumor characteristics (N = 465) and association between MMP-9:TIMP-1 complex and the clinicopathological parameters

From: Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study

Characteristics ELISA PLA
MMP-9:TIMP-1 MMP-1:TIMP-1
N Q1(%) Q2 Q3 Q4 P(χw2 test) Q1(%) Q2 Q3 Q4 P(χw2 test)
Age       0.12      0.27
<50 years 107 30 16 25 21   26 27 24 16  
50-69 years 257 50 62 48 60   57 49 56 59  
≥70 years 101 20 22 27 19   17 24 20 26  
Menopausal status       0.03      0.03
Premenopausal 142 40 22 31 28   36 35 31 20  
Postmenopausal 323 60 78 69 72   64 65 69 80  
Tumor size      0.96       0.87
0-20 mm 302 66 66 64 64   63 67 63 66  
>20 mm 163 34 34 36 36   37 33 37 34  
Malignancy grade*       0.06      0.65
Grade 1 196 42 57 41 42   40 49 46 45  
Grade 2-3** 239 58 43 59 58   60 51 54 55  
Unknown 7           
Lymph node status       0.73      0.44
Positive 220 44 47 48 51   42 46 51 51  
Negative 245 56 53 52 49   58 54 49 49  
Hormone receptor status       0.50      .084
(ER and/or PR)         84    
Positive 378 79 86 83 80   82 16 84 80  
Negative 82 21 14 17 20   18   16 20  
Unknown 5           
  1. *malignancy grade is only relevant in ductal or lobularcarcinoma, and therefore missing for 23 patients with other histological types.
  2. **Grade 2: 140, Grade 3: 99.
  3. Association between MMP-9:TIMP-1 complex and the clinicopathological parameters.