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Table 1 Patient, tumor characteristics (N = 465) and association between MMP-9:TIMP-1 complex and the clinicopathological parameters

From: Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study

Characteristics

ELISA

PLA

MMP-9:TIMP-1

MMP-1:TIMP-1

N

Q1(%)

Q2

Q3

Q4

P(χw2 test)

Q1(%)

Q2

Q3

Q4

P(χw2 test)

Age

     

0.12

    

0.27

<50 years

107

30

16

25

21

 

26

27

24

16

 

50-69 years

257

50

62

48

60

 

57

49

56

59

 

≥70 years

101

20

22

27

19

 

17

24

20

26

 

Menopausal status

     

0.03

    

0.03

Premenopausal

142

40

22

31

28

 

36

35

31

20

 

Postmenopausal

323

60

78

69

72

 

64

65

69

80

 

Tumor size

    

0.96

     

0.87

0-20 mm

302

66

66

64

64

 

63

67

63

66

 

>20 mm

163

34

34

36

36

 

37

33

37

34

 

Malignancy grade*

     

0.06

    

0.65

Grade 1

196

42

57

41

42

 

40

49

46

45

 

Grade 2-3**

239

58

43

59

58

 

60

51

54

55

 

Unknown

7

          

Lymph node status

     

0.73

    

0.44

Positive

220

44

47

48

51

 

42

46

51

51

 

Negative

245

56

53

52

49

 

58

54

49

49

 

Hormone receptor status

     

0.50

    

.084

(ER and/or PR)

       

84

   

Positive

378

79

86

83

80

 

82

16

84

80

 

Negative

82

21

14

17

20

 

18

 

16

20

 

Unknown

5

          
  1. *malignancy grade is only relevant in ductal or lobularcarcinoma, and therefore missing for 23 patients with other histological types.
  2. **Grade 2: 140, Grade 3: 99.
  3. Association between MMP-9:TIMP-1 complex and the clinicopathological parameters.