TY - JOUR AU - Thorsen, Stine B. AU - Christensen, Sarah LT AU - Würtz, Sidse Ø AU - Lundberg, Martin AU - Nielsen, Birgitte S. AU - Vinther, Lena AU - Knowles, Mick AU - Gee, Nick AU - Fredriksson, Simon AU - Møller, Susanne AU - Brünner, Nils AU - Schrohl, Anne-Sofie AU - Stenvang, Jan PY - 2013 DA - 2013/12/13 TI - Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study JO - BMC Cancer SP - 598 VL - 13 IS - 1 AB - Worldwide more than one million women are annually diagnosed with breast cancer. A considerable fraction of these women receive systemic adjuvant therapy; however, some are cured by primary surgery and radiotherapy alone. Prognostic biomarkers guide stratification of patients into different risk groups and hence improve management of breast cancer patients. Plasma levels of Matrix Metalloproteinase-9 (MMP-9) and its natural inhibitor Tissue inhibitor of metalloproteinase-1 (TIMP-1) have previously been associated with poor patient outcome and resistance to certain forms of chemotherapy. To pursue additional prognostic information from MMP-9 and TIMP-1, the level of the MMP-9 and TIMP-1 complex (MMP-9:TIMP-1) was investigated in plasma from breast cancer patients. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-13-598 DO - 10.1186/1471-2407-13-598 ID - Thorsen2013 ER -