Table 3 Pooled ORs and 95% CIs for ERCC2 rs13181 polymorphism of stratified meta-analysis
From: Association between polymorphisms in ERCC2 gene and oral cancer risk: evidence from a meta-analysis
Subgroup | Genotype | No of studies | Test of association | Test of heterogeneity | |||||
|---|---|---|---|---|---|---|---|---|---|
OR(95% CI) | Z | P-value | Model | χ 2 | P-value | I2(%) | |||
Asian | AC vs. AA | 4 | 1.16[0.88,1.36] | 0.83 | 0.405 | F | 5.81 | 0.121 | 48.3 |
CC vs. AA | 4 | 1.33[0.59,3.01] | 0.69 | 0.489 | R | 1.41 | 0.098 | 52.3 | |
AC + CC vs. AA | 4 | 1.13[0.75,1.71] | 0.59 | 0.555 | R | 8.79 | 0.032 | 65.9 | |
CC vs. AC + AA | 4 | 1.08[0.74,1.56] | 0.39 | 0.694 | F | 4.36 | 0.225 | 61.2 | |
C vs. A | 4 | 1.12[0.76,1.65] | 0.56 | 0.576 | R | 10.90 | 0.012 | 72.5 | |
Oral leukoplakia | AC vs. AA | 4 | 1.28[1.01,1.62] | 2.01 | 0.045 | F | 2.13 | 0.546 | 0.0 |
CC vs. AA | 4 | 1.94[0.99,3.79] | 1.95 | 0.052 | R | 7.52 | 0.057 | 60.1 | |
AC + CC vs. AA | 4 | 1.35[1.08,1.69] | 2.60 | 0.009 | F | 3.64 | 0.303 | 17.6 | |
CC vs. AC + AA | 4 | 1.67[0.90,3.13] | 1.63 | 0.102 | R | 7.20 | 0.066 | 58.3 | |
C vs. A | 4 | 1.38[1.04,1.82] | 2.26 | 0.024 | R | 6.88 | 0.043 | 56.4 | |
Oral cancer | AC vs. AA | 4 | 1.10[0.73,1.65] | 0.45 | 0.656 | R | 7.02 | 0.071 | 57.3 |
CC vs. AA | 4 | 1.07[0.69,1.69] | 0.31 | 0.758 | F | 5.26 | 0.154 | 43.0 | |
AC + CC vs. AA | 4 | 1.11[0.71,1.75] | 0.46 | 0.643 | R | 9.29 | 0.026 | 67.7 | |
CC vs. AC + AA | 4 | 1.01[0.66,1.55] | 0.06 | 0.951 | F | 3.13 | 0.371 | 4.3 | |
C vs. A | 4 | 1.09[0.73,1.64] | 0.44 | 0.661 | R | 10.22 | 0.064 | 55.0 | |