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Table 3 Univariate and multivariate analysis of variable factors for 5-year local recurrence free survival (LRFS)

From: Radiographic response to neoadjuvant therapy and its impact on scope of surgery and prognosis in stage IIB/III soft tissue sarcomas

Factors

LRFS

Univariate analysis

Multivariate analysis

RR

95% CI

P

RR

95% CI

P

Radiographic response

   

0.024

  

0.351

 PR (n = 25)

96.0

0.100

0.014-0.737

 

0.366

0.044-3.027

 

 SD + PD (n = 95)

65.0

1

  

1

  

Size (cm)

   

<0.001

  

0.572

 ≥10 (n = 63)

33.3

6.614

2.293-19.079

 

1.491

0.373-5.950

 

 <10 (n = 57)

81.4

1

  

1

  

FNCLCC Grade

   

<0.001

  

0.120

 Grade 2 (n = 45)

86.2

1

  

1

  

 Grade 3 (n = 75)

38.6

9.178

2.177-38.697

 

3.278

0.734-14.649

 

UICC margins

   

<0.001

  

<0.001

 R0 + R1 (n = 92)

69.9

1

  

1

  

 R2 (n = 28)

6.6

22.975

9.204-57.353

 

10.458

3.755-29.126

 

Surgery type

   

<0.001

  

0.672

 Resection only (n = 55)

89.4

1

  

1

  

 Resection with other modalities* (n = 65)

27.1

9.184

2.767-30.476

 

1.431

0.273-7.498

 
  1. *: Other modalities include epineural dissection and reconstruction of blood vessels and bony structures. FNCLCC: French Federation of Cancer Centres; UICC: Union Internationale Contre Cancer.