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Table 2 Univariate and multivariate analysis of variable factors for 5-year OS

From: Radiographic response to neoadjuvant therapy and its impact on scope of surgery and prognosis in stage IIB/III soft tissue sarcomas

Factors

OS

Univariate analysis

Multivariate analysis

RR

95% CI

P

RR

95% CI

P

Radiographic response

   

<0.001

   

 PR (n = 25)

96.0

0.081

0.027-0.239

 

0.133

0.037-0.483

0.002

 SD + PD (n = 95)

38.8

1

  

1

  

Size (cm)

   

<0.001

  

0.568

 ≥10 (n = 63)

33.5

5.276

2.704-10.294

 

1.263

0.566-2.818

 

 <10 (n = 57)

81.4

1

  

1

  

FNCLCC Grade

   

<0.001

  

0.001

 Grade 2 (n = 45)

86.2

1

  

1

  

 Grade 3 (n = 75)

38.7

6.188

2.647-14.467

 

5.146

2.028-13.058

 

UICC margins

   

<0.001

  

0.005

 R0 + R1 (n = 92)

69.9

1

  

1

  

 R2 (n = 28)

6.6

8.196

4.604-14.591

 

2.384

1.301-4.367

 

Surgery type

   

<0.001

  

0.027

 Resection only (n = 55)

89.4

1

  

1

  

 Resection with other modalities* (n = 65)

26.9

9.708

4.479-21.042

 

2.986

1.133-7.865

 
  1. *: Other modalities include epineural dissection and reconstruction of blood vessels and bony structures. FNCLCC: French Federation of Cancer Centres; UICC: Union Internationale Contre Cancer.