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Table 2 The most differentially regulated genes in gastric tumor vs control mucosa

From: Up-regulation of CLDN1 in gastric cancer is correlated with reduced survival

Up-regulated genes (n=30) Down-regulated genes (n=100)
Gene symbol Average FC Gene symbol Average FC Gene symbol Average FC Gene symbol Average FC
IL-8 2.58 PGA4 -5.58 MAL -2.22 AKR7A3 -1.79
COL1A1 2.18 GIF -5.48 SCNN1B -2.22 KIAA1324 -1.79
CLDN1 2.14 ATP4A -5.28 SOX21 -2.22 CCDC121 -1.78
SPP1 2.09 PGA3 -4.72 CAPN9 -2.21 FBP2 -1.76
CLDN2 2.09 ATP4B -4.71 AGXT2L1 -2.20 FCGBP -1.75
CEACAM6 2.09 PGA5 -4.34 HDC -2.18 ORM2 -1.75
SERPINB5 2.06 LIPF -3.91 GSTA1 -2.18 FAM3B -1.73
KRT17 2.00 CPA2 -3.78 KLK11 -2.12 TRIM50 -1.73
H19 1.94 GHRL -3.75 APLP1 -2.12 DUOX1 -1.72
CLDN7 1.93 GKN2 -3.26 MT1H -2.09 RAP1GAP -1.70
TFF3 1.92 KCNE2 -3.19 ADH1C -2.09 EEF1A2 -1.70
OLFM4 1.91 SST -3.12 DPCR1 -2.06 ANGPTL3 -1.70
THBS2 1.91 CHGA -3.02 AKR1B10 -2.03 B3GAT1 -1.69
PI3 1.90 PSCA -3.00 MT1G -2.03 C6ORF105 -1.68
SULF1 1.89 CHIA -2.88 CKB -2.01 FGG -1.68
BGN 1.82 GKN1 -2.88 SH3GL2 -1.99 ADA -1.65
KRT6B 1.80 KCNJ16 -2.82 REP15 -1.97 C6ORF58 -1.63
THY1 1.72 GC -2.66 CKM -1.95 ZNF533 -1.60
MMP11 1.70 CLIC6 -2.65 FGA -1.95 RPESP -1.59
KLK6 1.67 SOSTDC1 -2.53 SLC9A4 -1.92 MT1F -1.58
SERPINA3 1.65 ESRRG -2.52 MFSD4 -1.92 PNPLA7 -1.57
FNDC1 1.64 CCKBR -2.51 ALDOB -1.89 FUT9 -1.57
COL1A2 1.63 TMED6 -2.44 SCNN1G -1.87 RPRM -1.56
CST1 1.63 MT1M -2.44 IRX2 -1.87 GUCA2B -1.56
FAP 1.60 GPER -2.43 SLC26A9 -1.87 TCN1 -1.55
COL6A3 1.60 CKMT2 -2.36 CLCNKA -1.87 PKIB -1.55
SFRP4 1.56 VSIG2 -2.36 CAPN13 -1.86 SLC9A2 -1.55
TMEM158 1.53 FLJ42875 -2.33 TTR -1.86 HOMER2 -1.53
MMP7 1.50 CXCL17 -2.32 GSTA2 -1.85 AKR1C4 -1.50
MMP10 1.50 CA9 -2.32 NKX6-2 -1.83 REG3A -1.50
   AKR1C2 -2.27 CA2 -1.83 PI16 -1.50
   ALDH3A1 -2.24 FOLR1 -1.82 MAP7D2 -1.50
   SCGB2A1 -2.23 RDH12 -1.81   
   AQP4 -2.24 IRX3 -1.80   
  1. Differentially regulated genes with average log2FC of > 1.5 (n = 130). extracted from whole genome expression. Average log2FC levels corresponding to each gene are listed. Nine genes. shown in bold type. demonstrated similar regulation in both the current study and in a previous study where gastric epithelial cells were exposed to H. pylori[17].