Age and center stratified | Multivariable adjusted1 | Postmenopausal women2 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
ER+PR+ | ER-PR- | ER+PR+ | ER-PR- | ER+PR+ | ER-PR- | |||||||
(n = 3387) | (n = 944) | (n = 3387) | (n = 944 ) | (n = 1755) | (n = 477) | |||||||
Reproductive factor | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI |
Number of full-term childbirths 3 | ||||||||||||
1 child | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
2 children | 0.93 | (0.84-1.03) | 0.97 | (0.80-1.19) | 0.93 | (0.84-1.03) | 0.98 | (0.80-1.19) | 0.96 | (0.83-1.10) | 0.90 | (0.69-1.19) |
≥3 children | 0.77 | (0.68-0.87) | 0.83 | (0.66-1.05) | 0.77 | (0.68-0.87) | 0.84 | (0.66-1.06) | 0.79 | (0.67-0.93) | 0.90 | (0.65-1.22) |
P for trend | <0.001 | 0.09 | <0.001 | 0.10 | 0.002 | 0.54 | ||||||
Subtype heterogeneity4 | 0.53 | 0.47 | 0.22 | |||||||||
Age at first full-term childbirth 3 | ||||||||||||
≤19 years | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
20–24 years | 1.05 | (0.92-1.19) | 1.11 | (0.88-1.40) | 1.05 | (0.92-1.19) | 1.10 | (0.87-1.39) | 1.17 | (0.97-1.40) | 1.14 | (0.82-1.59) |
25–29 years | 1.16 | (0.99-1.35) | 0.96 | (0.72-1.28) | 1.16 | (0.99-1.36) | 0.96 | (0.72-1.28) | 1.32 | (1.05-1.64) | 1.02 | (0.68-1.54) |
30–34 years | 1.24 | (1.00-1.53) | 0.83 | (0.55-1.25) | 1.24 | (1.00-1.53) | 0.83 | (0.55-1.25) | 1.57 | (1.16-2.11) | 0.88 | (0.49-1.57) |
≥35 years | 1.32 | (0.96-1.82) | 0.69 | (0.35-1.36) | 1.30 | (0.95-1.79) | 0.69 | (0.35-1.36) | 1.64 | (1.05-2.56) | 0.81 | (0.32-2.03) |
P for trend | 0.02 | 0.19 | 0.02 | 0.19 | 0.002 | 0.51 | ||||||
Subtype heterogeneity4 | 0.03 | 0.03 | 0.05 | |||||||||
Age at last full-term childbirth 3 | ||||||||||||
Less than 25 | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
Between 25 and 30 | 0.90 | (0.80-1.02) | 1.15 | (0.93-1.44) | 0.90 | (0.80-1.02) | 1.16 | (0.93-1.44) | 0.87 | (0.74-1.02) | 1.13 | (0.83-1.53) |
Between 30 and 35 | 0.97 | (0.83-1.13) | 1.33 | (1.00-1.77) | 0.97 | (0.84-1.13) | 1.33 | (1.00-1.77) | 0.85 | (0.69-1.04) | 1.27 | (0.86-1.86) |
Greater than 35 | 0.89 | (0.72-1.09) | 1.29 | (0.88-1.90) | 0.89 | (0.73-1.10) | 1.30 | (0.88-1.91) | 0.83 | (0.63-1.10) | 1.39 | (0.83-2.34) |
P for trend | 0.53 | 0.10 | 0.58 | 0.09 | 0.18 | 0.18 | ||||||
Subtype heterogeneity4 | 0.17 | 0.17 | 0.09 | |||||||||
Time since last full-term childbirth 3 | ||||||||||||
≤20 years | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
>20 years | 0.87 | (0.77-0.98) | 1.01 | (0.81-1.26) | 0.86 | (0.77-0.97) | 1.00 | (0.80-1.25) | 0.90 | (0.73-1.12) | 1.10 | (0.74-1.65) |
P for significance | 0.02 | 0.94 | 0.02 | 0.99 | 0.35 | 0.63 | ||||||
Subtype heterogeneity4 | 0.24 | 0.24 | 0.29 |