| |
Age and center stratified
|
Multivariable adjusted1
|
Postmenopausal women2
|
|---|
| |
ER+PR+
|
ER-PR-
|
ER+PR+
|
ER-PR-
|
ER+PR+
|
ER-PR-
|
|---|
|
(n = 3387)
|
(n = 944)
|
(n = 3387)
|
(n = 944 )
|
(n = 1755)
|
(n = 477)
|
|---|
|
Reproductive factor
|
HR
|
95% CI
|
HR
|
95% CI
|
HR
|
95% CI
|
HR
|
95% CI
|
HR
|
95% CI
|
HR
|
95% CI
|
|
Number of full-term childbirths
3
|
|
1 child
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
|
2 children
|
0.93
|
(0.84-1.03)
|
0.97
|
(0.80-1.19)
|
0.93
|
(0.84-1.03)
|
0.98
|
(0.80-1.19)
|
0.96
|
(0.83-1.10)
|
0.90
|
(0.69-1.19)
|
|
≥3 children
|
0.77
|
(0.68-0.87)
|
0.83
|
(0.66-1.05)
|
0.77
|
(0.68-0.87)
|
0.84
|
(0.66-1.06)
|
0.79
|
(0.67-0.93)
|
0.90
|
(0.65-1.22)
|
|
P for trend
| |
<0.001
| |
0.09
| |
<0.001
| |
0.10
| |
0.002
| |
0.54
|
|
Subtype heterogeneity4
| | | |
0.53
| | | |
0.47
| | | |
0.22
|
|
Age at first full-term childbirth
3
|
|
≤19 years
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
|
20–24 years
|
1.05
|
(0.92-1.19)
|
1.11
|
(0.88-1.40)
|
1.05
|
(0.92-1.19)
|
1.10
|
(0.87-1.39)
|
1.17
|
(0.97-1.40)
|
1.14
|
(0.82-1.59)
|
|
25–29 years
|
1.16
|
(0.99-1.35)
|
0.96
|
(0.72-1.28)
|
1.16
|
(0.99-1.36)
|
0.96
|
(0.72-1.28)
|
1.32
|
(1.05-1.64)
|
1.02
|
(0.68-1.54)
|
|
30–34 years
|
1.24
|
(1.00-1.53)
|
0.83
|
(0.55-1.25)
|
1.24
|
(1.00-1.53)
|
0.83
|
(0.55-1.25)
|
1.57
|
(1.16-2.11)
|
0.88
|
(0.49-1.57)
|
|
≥35 years
|
1.32
|
(0.96-1.82)
|
0.69
|
(0.35-1.36)
|
1.30
|
(0.95-1.79)
|
0.69
|
(0.35-1.36)
|
1.64
|
(1.05-2.56)
|
0.81
|
(0.32-2.03)
|
|
P for trend
| |
0.02
| |
0.19
| |
0.02
| |
0.19
| |
0.002
| |
0.51
|
|
Subtype heterogeneity4
| | | |
0.03
| | | |
0.03
| | | |
0.05
|
|
Age at last full-term childbirth
3
|
|
Less than 25
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
|
Between 25 and 30
|
0.90
|
(0.80-1.02)
|
1.15
|
(0.93-1.44)
|
0.90
|
(0.80-1.02)
|
1.16
|
(0.93-1.44)
|
0.87
|
(0.74-1.02)
|
1.13
|
(0.83-1.53)
|
|
Between 30 and 35
|
0.97
|
(0.83-1.13)
|
1.33
|
(1.00-1.77)
|
0.97
|
(0.84-1.13)
|
1.33
|
(1.00-1.77)
|
0.85
|
(0.69-1.04)
|
1.27
|
(0.86-1.86)
|
|
Greater than 35
|
0.89
|
(0.72-1.09)
|
1.29
|
(0.88-1.90)
|
0.89
|
(0.73-1.10)
|
1.30
|
(0.88-1.91)
|
0.83
|
(0.63-1.10)
|
1.39
|
(0.83-2.34)
|
|
P for trend
| |
0.53
| |
0.10
| |
0.58
| |
0.09
| |
0.18
| |
0.18
|
|
Subtype heterogeneity4
| | | |
0.17
| | | |
0.17
| | | |
0.09
|
|
Time since last full-term childbirth
3
|
|
≤20 years
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
1.00
|
Reference
|
|
>20 years
|
0.87
|
(0.77-0.98)
|
1.01
|
(0.81-1.26)
|
0.86
|
(0.77-0.97)
|
1.00
|
(0.80-1.25)
|
0.90
|
(0.73-1.12)
|
1.10
|
(0.74-1.65)
|
|
P for significance
| |
0.02
| |
0.94
| |
0.02
| |
0.99
| |
0.35
| |
0.63
|
|
Subtype heterogeneity4
| | | |
0.24
| | | |
0.24
| | | |
0.29
|
-
1Stratified by age at recruitment and center and further adjusted for BMI, height, menopausal status at enrolment, HRT use, physical activity, smoking status, alcohol consumption and attained level of education; 2stratified by age at recruitment and center and further adjusted for BMI, height, HRT use, physical activity, smoking status, alcohol consumption and attained level of education; 3mutually adjusted for the pregnancy related variables in this table; 4heterogeneity between ER+PR+ and ER-PR- tumors was assessed on the trend score using the data augmentation method as described by Lunn and McNeil.
