Reproductive factor
|
Cases
|
HR
|
95% CI
|
Cases
|
HR
|
95% CI
|
Cases
|
HR
|
95% CI
|
Cases
|
HR
|
95% CI
|
Age at menarche
|
<13 years
|
1373
|
1.00
|
Reference
|
376
|
1.00
|
Reference
|
1373
|
1.00
|
Reference
|
376
|
1.00
|
Reference
|
14 years
|
1717
|
0.96
|
(0.90-1.04)
|
481
|
0.98
|
(0.86-1.13)
|
1717
|
0.96
|
(0.89-1.03)
|
481
|
0.97
|
(0.85-1.12)
|
≥15 years
|
439
|
0.76
|
(0.68-0.85)
|
135
|
0.85
|
(0.69-1.04)
|
439
|
0.76
|
(0.68-0.85)
|
135
|
0.84
|
(0.69-1.03)
|
P for trend
| | |
<0.001
| | |
0.17
| | |
<0.001
| | |
0.17
|
Subtype heterogeneity2
| | | | | |
0.44
| | | | | |
0.48
|
Age at menopause
3
|
≤48 years
|
464
|
1.00
|
Reference
|
135
|
1.00
|
Reference
|
464
|
1.00
|
Reference
|
135
|
1.00
|
Reference
|
49–50 years
|
397
|
1.10
|
(0.95-1.26)
|
116
|
1.09
|
(0.84-1.41)
|
397
|
1.12
|
(0.98-1.29)
|
116
|
1.09
|
(0.84-1.42)
|
51–54 years
|
280
|
1.04
|
(0.89-1.21)
|
63
|
0.88
|
(0.64-1.20)
|
280
|
1.06
|
(0.91-1.24)
|
63
|
0.87
|
(0.64-1.20)
|
≥55 years
|
121
|
1.19
|
(0.97-1.47)
|
32
|
1.06
|
(0.71-1.58)
|
121
|
1.17
|
(0.95-1.44)
|
32
|
1.03
|
(0.69-1.54)
|
P for trend
| | |
0.18
| | |
0.79
| | |
0.18
| | |
0.79
|
Subtype heterogeneity2
| | | | | |
0.40
| | | | | |
0.34
|
Ever a full-term birth
|
No
|
446
|
1.00
|
Reference
|
115
|
1.00
|
Reference
|
446
|
1.00
|
Reference
|
115
|
1.00
|
Reference
|
Yes
|
2994
|
0.86
|
(0.77-0.95)
|
843
|
0.97
|
(0.80-1.19)
|
2994
|
0.87
|
(0.78-0.96)
|
843
|
0.98
|
(0.80-1.20)
|
P for significance
| | |
0.003
| | |
0.78
| | |
0.01
| | |
0.78
|
Subtype heterogeneity2
| | | | | |
0.92
| | | | | |
0.88
|
Number of full-term childbirths
4
|
1 child
|
612
|
1.00
|
Reference
|
160
|
1.00
|
Reference
|
612
|
1.00
|
Reference
|
160
|
1.00
|
Reference
|
2 children
|
1497
|
0.92
|
(0.84-1.01)
|
432
|
1.02
|
(0.85-1.22)
|
1497
|
0.92
|
(0.84-1.01)
|
432
|
1.01
|
(0.84-1.22)
|
>3 children
|
840
|
0.77
|
(0.69-0.85)
|
244
|
0.89
|
(0.72-1.09)
|
840
|
0.76
|
(0.68-0.85)
|
244
|
0.89
|
(0.73-1.10)
|
P for trend
| | |
<0.001
| | |
0.19
| | |
<0.001
| | |
0.19
|
Subtype heterogeneity2
| | | | | |
0.22
| | | | | |
0.20
|
Age at first full-term childbirth
4
|
≤19 years
|
357
|
1.00
|
Reference
|
103
|
1.00
|
Reference
|
357
|
1.00
|
Reference
|
103
|
1.00
|
Reference
|
20–24 years
|
1369
|
1.06
|
(0.94-1.20)
|
431
|
1.20
|
(0.97-1.50)
|
1369
|
1.07
|
(0.95-1.21)
|
431
|
1.20
|
(0.96-1.50)
|
25–29 years
|
912
|
1.20
|
(1.06-1.36)
|
242
|
1.16
|
(0.92-1.47)
|
912
|
1.22
|
(1.07-1.39)
|
242
|
1.17
|
(0.92-1.50)
|
30–34 years
|
275
|
1.35
|
(1.15-1.59)
|
61
|
1.10
|
(0.80-1.52)
|
275
|
1.39
|
(1.18-1.64)
|
61
|
1.12
|
(0.81-1.56)
|
≤35 years
|
82
|
1.44
|
(1.13-1.83)
|
14
|
0.91
|
(0.52-1.60)
|
82
|
1.47
|
(1.15-1.88)
|
14
|
0.93
|
(0.53-1.65)
|
P for trend
| | |
<0.001
| | |
0.96
| | |
<0.001
| | |
0.96
|
Subtype heterogeneity2
| | | | | |
0.02
| | | | | |
0.03
|
Time between menarche and first full-term childbirth
4
|
<10 years
|
837
|
1.00
|
Reference
|
257
|
1.00
|
Reference
|
837
|
1.00
|
Reference
|
257
|
1.00
|
Reference
|
≥10 years
|
2133
|
1.21
|
(1.12-1.31)
|
592
|
1.14
|
(0.98-1.32)
|
2133
|
1.22
|
(1.12-1.33)
|
592
|
1.15
|
(0.99-1.34)
|
P for significance
| | |
<0.001
| | |
0.09
| | |
<0.001
| | |
0.09
|
Subtype heterogeneity2
| | | | | |
0.49
| | | | | |
0.52
|
Age at last full-term childbirth
4
|
≤24 years
|
463
|
1.00
|
Reference
|
138
|
1.00
|
Reference
|
463
|
1.00
|
Reference
|
138
|
1.00
|
Reference
|
25–29 years
|
1058
|
0.98
|
(0.88-1.10)
|
321
|
1.01
|
(0.82-1.23)
|
1058
|
0.98
|
(0.88-1.10)
|
321
|
1.01
|
(0.82-1.23)
|
30–34 years
|
984
|
1.07
|
(0.95-1.20)
|
263
|
0.97
|
(0.78-1.19)
|
984
|
1.07
|
(0.96-1.20)
|
263
|
0.98
|
(0.79-1.21)
|
≥35 years
|
490
|
1.11
|
(0.97-1.26)
|
130
|
1.01
|
(0.79-1.29)
|
490
|
1.12
|
(0.98-1.28)
|
130
|
1.03
|
(0.80-1.33)
|
P for trend
| | |
0.03
| | |
0.90
| | |
0.02
| | |
0.90
|
Subtype heterogeneity2
| | | | | |
0.24
| | | | | |
0.29
|
Time since last full-term childbirth
4
|
≤20 years
|
1043
|
1.00
|
Reference
|
300
|
1.00
|
Reference
|
1043
|
1.00
|
Reference
|
300
|
1.00
|
Reference
|
>20 years
|
1952
|
0.87
|
(0.78-0.96)
|
552
|
1.00
|
(0.82-1.22)
|
1952
|
0.86
|
(0.77-0.95)
|
552
|
0.98
|
(0.81-1.20)
|
P for significance
| | |
0.01
| | |
0.98
| | |
0.01
| | |
0.98
|
Subtype heterogeneity2
| | | | | |
0.20
| | | | | |
0.24
|
Ever breast-fed
4
|
No
|
538
|
1.00
|
Reference
|
152
|
1.00
|
Reference
|
538
|
1.00
|
Reference
|
152
|
1.00
|
Reference
|
Yes
|
2317
|
0.99
|
(0.90-1.09)
|
642
|
0.97
|
(0.81-1.16)
|
2317
|
0.99
|
(0.89-1.09)
|
642
|
0.98
|
(0.81-1.17)
|
P for significance
| | |
0.82
| | |
0.74
| | |
0.76
| | |
0.74
|
Subtype heterogeneity2
| | | | | |
0.85
| | | | | |
0.93
|
Total cumulative breastfeeding duration
4,5
|
<1 month
|
249
|
1.00
|
Reference
|
72
|
1.00
|
Reference
|
249
|
1.00
|
Reference
|
72
|
1.00
|
Reference
|
1–3 months
|
602
|
1.04
|
(0.89-1.20)
|
155
|
0.91
|
(0.69-1.21)
|
602
|
1.04
|
(0.89-1.20)
|
155
|
0.91
|
(0.69-1.21)
|
4–6 months
|
460
|
0.97
|
(0.83-1.14)
|
137
|
0.98
|
(0.74-1.32)
|
460
|
0.97
|
(0.83-1.14)
|
137
|
0.99
|
(0.74-1.32)
|
7–12 months
|
487
|
0.97
|
(0.83-1.13)
|
132
|
0.91
|
(0.68-1.22)
|
487
|
0.97
|
(0.83-1.13)
|
132
|
0.91
|
(0.68-1.23)
|
13–17 months
|
182
|
0.91
|
(0.75-1.11)
|
62
|
1.10
|
(0.78-1.57)
|
182
|
0.92
|
(0.75-1.12)
|
62
|
1.12
|
(0.79-1.60)
|
≥18 months
|
293
|
1.09
|
(0.91-1.31)
|
77
|
1.04
|
(0.73-1.46)
|
293
|
1.11
|
(0.92-1.33)
|
77
|
1.07
|
(0.75-1.51)
|
P for trend
| | |
0.99
| | |
0.54
| | |
0.90
| | |
0.54
|
Subtype heterogeneity2
| | | | | |
0.58
| | | | | |
0.53
|
Ever an abortion
6
|
No
|
1552
|
1.00
|
Reference
|
435
|
1.00
|
Reference
|
1552
|
1.00
|
Reference
|
435
|
1.00
|
Reference
|
Yes
|
1016
|
1.00
|
(0.92-1.08)
|
293
|
1.00
|
(0.86-1.16)
|
1016
|
0.99
|
(0.91-1.07)
|
293
|
1.00
|
(0.86-1.16)
|
P for significance
| | |
0.97
| | |
0.98
| | |
0.72
| | |
0.98
|
Subtype heterogeneity2
| | | | | |
0.97
| | | | | |
0.86
|
OC use at recruitment
|
Never OC user
|
1477
|
1.00
|
Reference
|
379
|
1.00
|
Reference
|
1477
|
1.00
|
Reference
|
379
|
1.00
|
Reference
|
Past OC user
|
1839
|
1.00
|
(0.93-1.08)
|
548
|
1.11
|
(0.96-1.28)
|
1839
|
0.97
|
(0.90-1.05)
|
548
|
1.09
|
(0.94-1.26)
|
Current OC user
|
108
|
1.20
|
(0.97-1.47)
|
33
|
1.08
|
(0.73-1.59)
|
108
|
1.19
|
(0.96-1.47)
|
33
|
1.09
|
(0.74-1.63)
|
P for trend
| | |
0.42
| | |
0.20
| | |
0.95
| | |
0.20
|
Subtype heterogeneity7
| | | | | |
0.34
| | | | | |
0.30
|
Age started OC
8
|
≤24 years
|
899
|
1.00
|
Reference
|
292
|
1.00
|
Reference
|
899
|
1.00
|
Reference
|
292
|
1.00
|
Reference
|
25–29 years
|
335
|
0.86
|
(0.75-0.99)
|
94
|
0.86
|
(0.66-1.11)
|
335
|
0.87
|
(0.76-1.00)
|
94
|
0.86
|
(0.66-1.11)
|
30–34 years
|
303
|
0.91
|
(0.78-1.07)
|
90
|
0.92
|
(0.69-1.23)
|
303
|
0.93
|
(0.79-1.08)
|
90
|
0.92
|
(0.69-1.22)
|
≥35 years
|
265
|
1.07
|
(0.90-1.28)
|
73
|
0.97
|
(0.70-1.36)
|
265
|
1.09
|
(0.91-1.30)
|
73
|
0.97
|
(0.70-1.36)
|
P for trend
| | |
0.83
| | |
0.75
| | |
0.67
| | |
0.75
|
Subtype heterogeneity2
| | | | | |
0.70
| | | | | |
0.61
|
Duration of OC use
8
|
1 year or less
|
396
|
1.00
|
Reference
|
114
|
1.00
|
Reference
|
396
|
1.00
|
Reference
|
114
|
1.00
|
Reference
|
2–4 years
|
450
|
1.02
|
(0.89-1.17)
|
116
|
0.86
|
(0.66-1.12)
|
450
|
1.03
|
(0.89-1.18)
|
116
|
0.86
|
(0.67-1.12)
|
5–9 years
|
426
|
1.06
|
(0.92-1.22)
|
122
|
0.97
|
(0.75-1.26)
|
426
|
1.06
|
(0.92-1.22)
|
122
|
0.97
|
(0.75-1.27)
|
≥10 years
|
521
|
1.02
|
(0.89-1.17)
|
187
|
1.11
|
(0.87-1.41)
|
521
|
1.02
|
(0.89-1.18)
|
187
|
1.11
|
(0.87-1.42)
|
P for trend
| | |
0.70
| | |
0.21
| | |
0.68
| | |
0.21
|
Subtype heterogeneity2
| | | | | |
0.36
| | | | | |
0.37
|