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The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

  • Zeze Fu1,
  • Biyong Deng1,
  • Yuxin Liao1,
  • Liancheng Shan2, 1,
  • Fei Yin1,
  • Zhuoying Wang1,
  • Hui Zeng1,
  • Dongqing Zuo1,
  • Yingqi Hua1Email author and
  • Zhengdong Cai1Email author
Contributed equally
BMC Cancer201313:580

Received: 2 September 2013

Accepted: 4 December 2013

Published: 6 December 2013

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
2 Sep 2013 Submitted Original manuscript
10 Nov 2013 Reviewed Reviewer Report - hemant kumar bid
18 Nov 2013 Reviewed Reviewer Report - Hao Tang
1 Dec 2013 Author responded Author comments - Zeze Fu
Resubmission - Version 2
1 Dec 2013 Submitted Manuscript version 2
4 Dec 2013 Editorially accepted
6 Dec 2013 Article published 10.1186/1471-2407-13-580

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine, Shanghai, China
Postdoctoral Research Station of School of Life Science and Technology of Tongji University, Shanghai, China