Figure 5
From: The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis
Survival of mice treated with DMSO and shikonin respectively. The lung metastatic models were constructed by osteosarcoma K7 cells in 4-week-old female Balb/c mice. The experimental group (n = 10) was injected with shikonin (2.0 mg/kg, diluted with 5% DMSO) while control group (n = 10) was injeced with 5% DMSO intraperitoneally every other day. The survival time in shikonin group was longer than that in control group significantly (p < 0.001).