Measuring telomere length for the early detection of precursor lesions of esophageal squamous cell carcinoma

BMC Cancer

Table 4 Association between telomere length ^a and high-grade dysplasia compared with all other diagnoses

	Controls and all other diagnoses^b	High-grade dysplasia^c
		Cases	OR (95% CI)
Unadjusted
Continuous^d	179	52	1.14 (0.91-1.43)
Quartiles
<0.784	37	10	ref
0.784 - <0.925	61	14	0.85 (0.34-2.11)
0.925 - <1.047	37	13	1.30 (0.51-3.34)
≥1.047	44	15	1.26 (0.51-3.14)
p-trend			0.728
Adjusted^e
Continuous^d	179	52	1.17 (0.93-1.37)
Quartiles
<0.784	37	10	ref
0.784 - <0.925	61	14	0.93 (0.36-2.37)
0.925 - <1.047	37	13	1.43 (0.55-3.76)
≥1.047	44	15	1.39 (0.55-3.54)
p-trend			0.684

^aCalculated as telomeric DNA (T) divided by amount of single-copy control gene DNA (S) to produce the relative measurement of telomere length (T/S ratio).
^bCategory includes normal controls, esophagitis cases, and mild dysplasia cases.
^cHigh-grade dysplasia category includes moderate and severe dysplasia cases.
^dContinuous telomere length scaled by half the interquartile range based on the distribution among the normal controls.
^eModels adjusted for age, sex, BMI, tobacco smoking, alcohol drinking, and hypertension.
Abbreviations: OR, odds ratio; CI, confidence interval; BMI, body mass index.

ISSN: 1471-2407