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Table 4 Association between telomere length a and high-grade dysplasia compared with all other diagnoses

From: Measuring telomere length for the early detection of precursor lesions of esophageal squamous cell carcinoma

  Controls and all other diagnosesb High-grade dysplasiac
   Cases OR (95% CI)
Unadjusted    
  Continuousd 179 52 1.14 (0.91-1.43)
  Quartiles    
   <0.784 37 10 ref
   0.784 - <0.925 61 14 0.85 (0.34-2.11)
   0.925 - <1.047 37 13 1.30 (0.51-3.34)
   ≥1.047 44 15 1.26 (0.51-3.14)
   p-trend    0.728
Adjustede    
  Continuousd 179 52 1.17 (0.93-1.37)
  Quartiles    
   <0.784 37 10 ref
   0.784 - <0.925 61 14 0.93 (0.36-2.37)
   0.925 - <1.047 37 13 1.43 (0.55-3.76)
   ≥1.047 44 15 1.39 (0.55-3.54)
   p-trend    0.684
  1. aCalculated as telomeric DNA (T) divided by amount of single-copy control gene DNA (S) to produce the relative measurement of telomere length (T/S ratio).
  2. bCategory includes normal controls, esophagitis cases, and mild dysplasia cases.
  3. cHigh-grade dysplasia category includes moderate and severe dysplasia cases.
  4. dContinuous telomere length scaled by half the interquartile range based on the distribution among the normal controls.
  5. eModels adjusted for age, sex, BMI, tobacco smoking, alcohol drinking, and hypertension.
  6. Abbreviations: OR, odds ratio; CI, confidence interval; BMI, body mass index.