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Table 3 Cumulative promoter hypermethylation of WIF1, PENK, and NPY DNA in serum

From: Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer

 

CMI

Specificity

Sensitivity

Series 1

0.62

73 (22/30)

100 (9/9)

 

0.68-0.75

>80

>80

 

1.15

90

66

 

2.85

95

66

Series 2

0.01

25 (33/131)

91 (21/23)

 

0.60-0.73

>80

>80

 

0.94

90

75

 

2.48

96

52

Pooled 1 + 2

0.05

34 (55/161)

94 (30/32)

 

0.62-0.85

>80

>80

 

0.94

90

75

 

2.01

95

59

  1. Sensitivity (Se) and Specificity (Sp) are shown at several CMI thresholds for both CRC series: Se > 90% (CMI = 0.62 for Series 1 and 0.01 for Series 2), Sp > 90% (1.15 and 0.94) and Sp > 95% (2.85 and 2.48). We note the existence of two similar numerical ranges for the thresholds (0.68-0.75 for Series 1 and 0.60-0.73 for Series 2) where both Sp and Se are high (>80%). CMI values are the cumulative methylation index of three genes.