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Table 3 Cumulative promoter hypermethylation of WIF1, PENK, and NPY DNA in serum

From: Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer

  CMI Specificity Sensitivity
Series 1 0.62 73 (22/30) 100 (9/9)
  0.68-0.75 >80 >80
  1.15 90 66
  2.85 95 66
Series 2 0.01 25 (33/131) 91 (21/23)
  0.60-0.73 >80 >80
  0.94 90 75
  2.48 96 52
Pooled 1 + 2 0.05 34 (55/161) 94 (30/32)
  0.62-0.85 >80 >80
  0.94 90 75
  2.01 95 59
  1. Sensitivity (Se) and Specificity (Sp) are shown at several CMI thresholds for both CRC series: Se > 90% (CMI = 0.62 for Series 1 and 0.01 for Series 2), Sp > 90% (1.15 and 0.94) and Sp > 95% (2.85 and 2.48). We note the existence of two similar numerical ranges for the thresholds (0.68-0.75 for Series 1 and 0.60-0.73 for Series 2) where both Sp and Se are high (>80%). CMI values are the cumulative methylation index of three genes.