| CMI | Specificity | Sensitivity |
---|
Series 1 | 0.62 | 73 (22/30) | 100 (9/9) |
 | 0.68-0.75 | >80 | >80 |
 | 1.15 | 90 | 66 |
 | 2.85 | 95 | 66 |
Series 2 | 0.01 | 25 (33/131) | 91 (21/23) |
 | 0.60-0.73 | >80 | >80 |
 | 0.94 | 90 | 75 |
 | 2.48 | 96 | 52 |
Pooled 1 + 2 | 0.05 | 34 (55/161) | 94 (30/32) |
 | 0.62-0.85 | >80 | >80 |
 | 0.94 | 90 | 75 |
 | 2.01 | 95 | 59 |
- Sensitivity (Se) and Specificity (Sp) are shown at several CMI thresholds for both CRC series: Se > 90% (CMI = 0.62 for Series 1 and 0.01 for Series 2), Sp > 90% (1.15 and 0.94) and Sp > 95% (2.85 and 2.48). We note the existence of two similar numerical ranges for the thresholds (0.68-0.75 for Series 1 and 0.60-0.73 for Series 2) where both Sp and Se are high (>80%). CMI values are the cumulative methylation index of three genes.