Skip to main content

Table 4 Age-adjusted odds ratio and multivariate adjusted odds ratio with 95% confidence intervals for lifestyle factors in rs3757318

From: Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case–control study in Japanese women

  

Risk allele carriers(AA + AG) n = 397

non-risk allele carriers(GG) n = 530

  

Case n = 216/Control n = 181

Case n = 249/Control n = 281

  

n/n

ORa(95%CI)

p

ORb(95% CI)

p

n/n

ORa(95% CI)

p

ORc(95% CI)

p

Age (years)

 

54.23/53.30

      

55.28/53.76

      

Menopausal status

Pre

124/101

      

154/170

      
 

Post

92/80

      

95/111

      

Height (cm)

≤150

36/28

1.24

(0.66-2.34)

0.50

1.46

(0.68-3.16)

0.33

58/50

1.07

(0.65-1.77)

0.78

1.01

(0.60-1.69)

0.98

 

151-155

62/63

Ref.

  

Ref.

  

84/80

Ref.

  

ref.

  
 

156-160

78/51

1.57

(0.96-260)

0.07

1.57

(0.86-2.90)

0.14

72/105

0.68

(0.44-1.05)

0.08

0.73

(0.47-1.15)

0.18

 

>160

36/38

1.00

(0.55-1.80)

0.99

0.58

(0.26-1.24)

0.16

34/43

0.80

(0.46-1.39)

0.43

0.89

(0.50-1.59)

0.70

BMI(Kg/m2)

<20

48/37

1.36

(0.77-2.40)

0.26

1.11

(0.54-2.29)

0.77

54/59

1.57

(0.95-2.59)

0.06

1.60

(0.95-2.69)

0.08

 

20-21.9

59/60

Ref.

  

Ref.

  

54/90

Ref.

  

Ref.

  
 

22-23.9

47/35

1.35

(0.77-2.40)

0.24

1.57

(0.80-3.12)

0.19

57/66

1.41

(0.86-2.30)

0.40

1.29

(0.78-2.14)

0.32

 

≥24

57/48

1.18

(0.69-2.01)

0.51

1.14

(0.60-2.17)

0.68

81/63

2.08

(1.29-3.37)

<0.01

1.89

(1.16-3.10)

0.01

Smoking status

Never

186/168

Ref.

  

Ref.

  

214/262

Ref.

  

Ref.

  
 

Current or former

25/11

2.15

(1.05-4.71)

0.04

2.73

(1.07-7.65)

0.04

34/17

2.82

(1.53-5.40)

<0.01

2.39

(1.27-4.65)

<0.01

Alcohol drinking

Never

114/90

Ref.

  

Ref.

  

124/127

Ref.

  

Ref.

  
 

Current or former

101/89

0.93

(0.62-1.39)

0.71

0.99

(0.60-1.65)

0.97

125/153

0.90

(0.63-1.28)

0.55

0.95

(0.65-1.38)

0.78

Alcohol intake

0

114/90

Ref.

  

Ref.

  

124/127

Ref.

  

Ref.

  

(g/day)

<5

59/45

1.08

(0.67-1.76)

0.75

1.12

(0.61-2.04)

0.72

78/84

1.01

(0.67-1.51)

0.98

1.11

(0.72-1.70)

0.64

 

5-10

27/27

0.81

(0.44-1.49)

0.50

0.88

(0.41-1.90)

0.75

25/35

0.79

(0.44-1.41)

0.43

0.89

(0.49-1.63)

0.71

 

10>

13/16

0.65

(0.29-1.41)

0.27

0.78

(0.27-2.14)

0.63

22/29

0.82

(0.44-1.52)

0.54

0.66

(0.33-1.28)

0.22

Leisure-time

No

122/80

Ref.

  

Ref.

  

127/133

Ref.

  

Ref.

  

Exercise

Yes

93/101

0.58

(0.39-0.87)

<0.01

0.78

(0.47-1.27)

0.32

119/146

0.82

(0.58-1.17)

0.27

0.84

(0.59-1.21)

0.35

Intensity of physical activityd(met/week)

0

122/81

Ref.

  

Ref.

  

126/137

Ref.

  

Ref.

  

>6.0

23/17

0.87

(0.44-1.76)

0.70

1.62

(0.68-4.03)

0.28

28/25

1.24

(0.68-2.27)

0.48

1.19

(0.64-2.25)

0.58

 

6.0-11.9

21/25

0.55

(0.28-1.04)

0.07

0.58

(0.27-1.21)

0.15

23/34

0.68

(0.37-1.22)

0.20

0.69

(0.37-1.28)

0.24

 

12.0-23.9

19/32

0.39

(0.20-0.73)

<0.01

0.73

(0.33-1.56)

0.41

29/48

0.63

(0.37-1.06)

0.08

0.62

(0.36-1.06)

0.08

 

≥24.0

23/26

0.56

(0.29-1.06)

0.07

0.67

(0.31-1.42)

0.29

27/35

0.79

(0.45-1.39)

0.42

0.84

(0.47-1.50)

0.55

Age at menarche

≤12

63/73

1.00

(0.59-1.70)

0.99

1.67

(0.85-3.33)

0.14

73/127

0.77

(0.47-1.24)

0.28

0.74

(0.45-1.22)

0.24

(year)

13

52/51

Ref.

  

Ref.

  

57/61

Ref.

  

Ref.

  
 

≤14

99/56

1.39

(0.82-2.35)

0.22

1.74

(0.90-3.37)

0.10

115/88

1.12

(0.70-1.81)

0.63

1.02

(0.62-1.68)

0.92

Parity

0

49/24

Ref.

  

Ref.

  

37/50

Ref.

  

Ref.

  
 

1-2

110/105

0.48

(0.27-0.84)

<0.01

0.55

(0.19-1.54)

0.25

132/160

0.98

(0.60-1.62)

0.95

1.19

(0.70-2.05)

0.52

 

≥3

36/48

0.34

(0.17-0.65)

<0.01

0.35

(0.12-1.04)

0.06

65/58

1.36

(0.77-2.40)

0.29

1.74

(0.95-3.21)

0.07

Age at first childbirth

<25

60/60

1.05

(0.64-1.71)

0.86

0.97

(0.56-1.66)

0.90

88/82

1.35

(0.89-2.05)

0.15

1.19

(0.77-1.84)

0.43

(year)

25-29

72/77

      

88/110

Ref.

  

Ref.

  
 

≥30

34/19

1.96

(1.03-3.80)

0.04

1.82

(0.88-3.85)

0.11

29/31

1.17

(0.66-2.10)

0.59

1.27

(0.69-2.33)

0.45

Breastfeeding

No

65/38

Ref.

  

Ref.

  

59/65

Ref.

  

Ref.

  
 

Yes

150/143

0.60

(0.38-0.95)

0.03

0.93

(0.36-2.43)

0.89

183/211

0.91

(0.61-1.38)

0.67

1.07

(0.69-1.65)

0.77

Family history of

No

173/143

Ref.

  

Ref.

  

212/229

Ref.

  

Ref.

  

Breast cancer

Yes

24/19

1.04

(0.55-2.00)

0.79

1.30

(0.56-3.07)

0.54

28/33

0.91

(0.53-1.57)

0.93

0.90

(0.51-1.58)

0.72

Education

High school or less

113/80

Ref.

  

Ref.

  

144/115

Ref.

  

Ref.

  
 

Two-year college

74/54

0.99

(0.62-1.57)

0.96

1.02

(0.58-1.79)

0.94

66/90

0.60

(0.40-0.91)

0.01

0.63

(0.42-0.96)

0.03

 

University

27/45

0.43

(0.24-0.76)

<0.01

0.33

(0.16-0.67)

0.00

36/74

0.40

(0.25-0.64)

<0.01

0.45

(0.28-0.73)

<0.01

  1. aOR is adjusted for age.
  2. bMultivariate adjusted for smoking state, leisure-time exercise, party, age of first children, breastfeeding and education. cMultivariate adjusted for BMI, smoking state, and education. dIntensity of physical activity and education. Significant dates are showed in boldface. OR, odds ratio; CI, confidence interval; BMI, body mass index.
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us