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Table 3 Age-adjusted odds ratio and multivariate adjusted odds ratio with 95% confidence intervals for lifestyle factors in rs2046210

From: Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case–control study in Japanese women

  

Risk allele carriers (AA + AG) n = 474

Non-risk allele carriers (GG) n = 457

  

Case n = 255/Control n = 219

Case n = 213/Control n = 244

  

n/n

ORa(95% CI)

p

ORb(95% CI)

p

n/n

ORa(95% CI)

p

ORc(95% CI)

p

Age (years)

 

54.0/53.9

      

55.8/53.2

      

Menopausal status

Pre

148/133

      

130/137

      
 

Post

107/86

      

83/107

      

Height (cm)

≤150

40/39

1.03

(0.58-1.83)

0.93

0.96

(0.53-1.74)

0.89

55/39

1.34

(0.78-2.9)

0.29

1.19

(0.66-2.14)

0.57

 

151-155

76/77

Ref.

  

Ref.

  

68/68

Ref.

  

Ref.

  
 

156-160

89/66

1.38

(0.88-2.16)

0.16

1.44

(0.91-2.29)

0.12

63/89

0.76

(0.48-1.3)

0.27

0.89

(0.53-1.48)

0.64

 

>160

46/34

1.41

(0.81-2.47)

0.23

1.62

(0.91-2.91)

0.10

25/47

0.59

(0.32-1.08)

0.09

0.51

(0.25-0.99)

0.05

BMI (Kg/m2)

20

59/46

1.27

(0.75-2.14)

0.37

1.13

(0.67-1.94)

0.64

43/50

1.62

(0.93-2.81)

0.09

1.54

(0.84-2.82)

0.16

 

20-21.9

69/67

Ref.

  

Ref.

  

48/82

Ref.

  

Ref.

  
 

22-23.9

58/50

1.09

(0.66-1.80)

0.75

0.97

(0.58-1.63)

0.92

43/52

1.40

(0.82-2.40)

0.22

1.47

(0.83-2.63)

0.19

 

≥24

65/53

1.17

(0.71-1.94)

0.53

1.09

(0.65-1.82)

0.74

74/59

2.07

(1.26-3.43)

<0.01

1.91

(1.11-3.29)

0.02

Smoking status

Never

222/201

Ref.

  

Ref.

  

180/230

Ref.

  

Ref.

  
 

Current or former

29/15

1.78

(0.93-3.51)

0.08

1.61

(0.83-3.21)

0.16

31/13

3.82

(1.94-7.98)

<0.01

3.86

(1.87-8.37)

<0.01

Alcohol drinking

Never

129/107

Ref.

  

Ref.

  

108/111

Ref.

  

Ref.

  
 

Current or former

125/109

0.97

(0.67-1.40)

0.97

1.07

(0.73-1.57)

0.74

105/133

0.91

(0.62-1.33)

0.61

0.87

(0.56-1.33)

0.51

Alcohol intake (g/day)

0

129/107

Ref.

  

Ref.

  

108/111

Ref.

  

Ref.

  
 

<5

75/56

1.12

(0.72-1.74)

0.61

1.22

(0.78-1.92)

0.39

64/73

0.99

(0.64-1.54)

0.98

0.98

(0.60-1.61)

0.94

 

5-10

28/32

0.75

(0.42-1.34)

0.34

0.88

(0.49-1.60)

0.68

25/30

0.94

(0.51-1.72)

0.85

0.92

(0.46-1.80)

0.80

 

10>

20/19

0.88

(0.44-1.74)

0.71

0.94

(0.46-1.89)

0.85

16/26

0.70

(0.35-1.38)

0.31

0.55

(0.24-1.22)

0.14

Leisure-time exercise

No

143/97

Ref.

  

Ref.

  

110/116

Ref.

  

Ref.

  
 

Yes

110/121

0.62

(0.43-0.89)

0.01

0.60

(0.41-0.87)

<0.01

101/127

0.77

(0.52-1.12)

0.17

0.74

(0.49-1.11)

0.14

Intensity of physical activityd (met/week)

0

143/99

Ref.

  

Ref.

  

109/119

Ref.

  

Ref.

  

>6.0

25/23

0.79

(0.42-1.48)

0.45

0.72

(0.38-1.37)

0.32

25/19

1.35

(0.70-2.63)

0.37

1.20

(0.59-2.48)

0.61

 

6.0-11.9

20/28

0.49

(0.26-0.92)

0.03

0.46

(0.24-0.86)

0.02

22/32

0.63

(0.34-1.17)

0.15

0.66

(0.34-1.28)

0.22

 

12.0-23.9

27/36

0.52

(0.29-0.91)

0.02

0.53

(0.30-0.94)

0.03

21/44

0.48

(0.26-0.85)

0.01

0.45

(0.24-0.83)

0.01

 

≥24.0

30/32

0.65

(0.37-1.14)

0.13

0.68

(0.38-1.20)

0.18

22/29

0.74

(0.40-1.38)

0.35

0.70

(0.36-1.36)

0.30

Age at menarche

≤12

70/92

0.73

(0.45-1.19)

0.73

0.72

(0.44-1.19)

0.20

68/109

1.07

(0.63-1.81)

0.80

0.98

(0.56-1.70)

0.93

(year)

13

66/55

Ref.

  

Ref.

  

43/58

Ref.

  

Ref.

  
 

≤14

116/68

1.20

(0.74-1.93)

1.20

1.15

(0.71-1.89)

0.57

99/75

1.32

(0.78-2.25)

0.29

1.62

(0.93-2.84)

0.09

Parity

0

54/35

Ref.

  

Ref.

  

31/40

Ref.

  

Ref.

  
 

1-2

123/122

0.63

(0.38-1.04)

0.07

0.66

(0.40-1.10)

0.11

124/143

0.95

(0.55-1.64)

0.85

1.12

(0.61-2.09)

0.71

 

≥3

54/53

0.65

(0.36-1.15)

0.14

0.65

(0.36-1.17)

0.15

46/53

0.94

(0.50-1.76)

0.84

1.29

(0.64-2.62)

0.48

Age at first childbirth

<25

78/68

1.21

(0.77-1.90)

0.40

1.08

(0.68-1.71)

0.74

72/74

1.22

(0.78-1.91)

0.38

1.17

(0.71-1.91)

0.54

(year)

25-29

87/89

Ref.

  

Ref.

  

75/97

Ref.

  

Ref.

  
 

≥30

33/22

1.55

(0.84-2.90)

0.16

1.45

(0.77-2.76)

0.25

30/28

1.39

(0.77-2.54)

0.27

1.77

(0.92-3.45)

0.09

Breastfeeding

No

72/51

Ref.

  

Ref.

  

51/53

Ref.

  

Ref.

  
 

Yes

178/165

0.76

(0.50-1.16)

0.21

0.77

(0.50-1.17)

0.22

159/189

0.83

(0.53-1.30)

0.42

1.02

(0.62-1.69)

0.93

Family history of

No

209/180

Ref.

  

Ref.

  

178/192

Ref.

  

Ref.

  

Breast cancer

Yes

31/24

1.11

(0.63-1.97)

0.55

1.12

(0.63-2.00)

0.71

22/28

0.82

(0.45-1.50)

0.75

1.07

(0.57-2.05)

0.83

Education

High school or less

135/99

Ref.

  

Ref.

  

123/96

Ref.

  

Ref.

  
 

Two-year college

81/63

0.93

(0.61-1.42)

0.74

0.95

(0.62-1.47)

0.83

60/81

0.62

(0.40-0.95)

0.03

0.59

(0.37-0.94)

0.03

 

University

36/55

0.48

(0.29-0.79)

<0.01

0.48

(0.29-0.79)

<0.01

28/65

0.35

(0.21-0.59)

<0.01

0.38

(0.22-0.66)

<0.01

  1. aOR is adjusted for age.
  2. bMultivariate adjusted for leisure-time exercise and education. cMultivariate adjusted for BMI, smoking state, intensity of physical activity and education.
  3. dIntensity of physical activity and education. Significant dates are showed in boldface.
  4. OR, odds ratio; CI, confidence interval; BMI, body mass index.
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