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Table 2 Odds ratio with 95% confidence intervals for individual SNPs in all subjects and in subjects stratified by menopausal status

From: Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case–control study in Japanese women

  

All women (n = 936)

Premenopausal (n = 385)

Postmenopausal (n = 551)

SNP

 

No. of

Adjusted ORb

Multivariate ORc

No. of

Adjusted ORb

Multivariate ORc

No. of

Adjusted ORb

Multivariate ORc

Gene/location

Genotypea

Case/Control

OR (95% CI)

OR (95% CI)

Case/Control

OR (95% CI)

OR (95% CI)

Case/Control

OR (95% CI)

OR (95% CI)

rs1562430

CC

7/4

Ref.

 

Ref.

 

2/3

Ref.

 

Ref.

  

Ref.

 

Ref.

 

/8q24

TC

96/102

0.54

(0.14-1.85)

0.62

(0.15‒2.32)

33/42

1.24

(0.19-9.85)

1.10

(0.15-10.05)

5/1

0.24

(0.01-1.54)

0.35

(0.02-2.80)

 

TT

369/351

0.61

(0.16-2.05)

0.67

(0.16‒2.45)

155/146

1.64

(0.27-12.63)

1.72

(0.24-15.14)

63/60

0.24

(0.01-1.52)

0.29

(0.01-2.25)

 

Per allele

 

1.05

(0.79-1.39)

1.02

(0.75‒1.39)

 

1.08

(0.81-1.45)

1.62

(1.08-2.44)

214/205

1.07

(0.85-1.36)

0.80

(0.56-1.14)

rs889132

AA

76/91

Ref.

 

Ref.

 

34/36

Ref.

 

Ref.

  

Ref.

 

Ref.

 

MAP3K1/5q

CA

227/211

1.27

(0.89-1.83)

1.27

(0.86‒1.88)

91/95

0.96

(0.55-1.65)

0.82

(0.45-1.50)

42/55

1.59

(0.98-2.58)

1.57

(0.91-2.76)

 

CC

164/160

1.21

(0.83-1.76)

1.21

(0.81‒1.81)

64/61

1.07

(0.60-1.92)

0.98

(0.52-1.84)

136/116

1.35

(0.82-2.23)

1.30

(0.74-2.30)

 

Per allele

 

1.07

(0.89-1.29)

1.07

(0.88‒1.31)

 

1.08

(0.81-1.45)

1.11

(0.83-1.49)

100/99

1.07

(0.85-1.36)

1.05

(0.81-1.36)

rs13283615

AA

75/75

Ref.

 

Ref.

 

29/31

Ref.

 

Ref.

  

ref.

 

ref.

 

/8q24

GA

211/206

1.04

(0.71-1.51)

1.09

(0.73‒1.65)

73/80

0.97

(0.53-1.76)

1.13

(0.60-2.17)

46/44

1.10

(0.68-1.79)

1.17

(0.67-2.05)

 

GG

180/177

1.03

(0.70-1.51)

1.02

(0.67‒1.55)

86/78

1.14

(0.63-2.05)

1.18

(0.62-2.24)

138/126

0.97

(0.58-1.61)

1.09

(0.61-1.97)

 

Per allele

 

1.01

(0.84-1.21)

1.00

(0.81‒1.22)

 

1.11

(0.84-1.47)

1.03

(1.00-1.05)

94/99

0.95

(0.74-1.21)

0.99

(0.76-1.28)

rs981782

TT

166/149

Ref.

 

Ref.

 

67/64

Ref.

 

Ref.

  

Ref.

 

Ref.

 

HCN1/5p12

TG

220/234

0.85

(0.64-1.14)

0.82

(0.60‒1.13)

88/98

0.85

(0.54-1.33)

0.78

(0.48-1.26)

99/85

0.87

(0.59-1.27)

0.83

(0.54-1.29)

 

GG

82/76

0.96

(0.66-1.41)

0.88

(0.58‒1.34)

31/28

1.03

(0.56-1.91)

0.97

(0.50-1.90)

132/136

0.93

(0.57-1.52)

0.76

(0.43-1.34)

 

Per allele

 

0.95

(0.79-1.14)

0.97

(0.80‒1.17)

 

1.00

(0.75-1.35)

1.01

(0.74-1.38)

51/48

0.93

(0.73-1.18)

0.86

(0.66-1.13)

rs3803662

CC

74/91

Ref.

 

Ref.

 

24/42

Ref.

 

Ref.

  

Ref.

 

Ref.

 

TNRC9/16q12

TC

230/227

1.25

(0.88-1.79)

1.32

(0.89‒1.96)

89/96

1.59

(0.90-2.85)

1.50

(0.81-2.80)

50/49

1.08

(0.68-1.72)

1.25

(0.73-2.16)

 

TT

160/142

1.41

(0.97-2.08)

1.61

(1.06‒2.45)

72/53

2.29

(1.25-4.26)

2.29

(1.20-4.46)

141/131

1.04

(0.63-1.71)

1.27

(0.72-2.24)

 

Per allele

 

1.18

(0.98-1.42)

1.28

(1.07‒1.55)

 

1.54

(1.15-2.09)

1.58

(1.17-2.16)

88/89

1.00

(0.78-1.28)

1.07

(0.83-1.39)

rs381798

TT

339/347

Ref.

 

Ref.

 

138/140

Ref.

 

Ref.

  

Ref.

 

Ref.

 

LSP1/11p15.5

CT

120/107

1.14

(0.85-1.55)

1.07

(0.77‒1.49)

46/49

0.92

(0.58-1.48)

1.00

(0.60-1.68)

201/207

1.30

(0.87-1.94)

1.18

(0.75-1.86)

 

CC

10/5

2.04

(0.72-6.60)

1.63

(0.52‒5.66)

4/1

3.98

(0.58-78.39)

3.29

(0.42-68.89)

74/58

1.65

(0.46-6.55)

1.39

(0.32-6.31)

 

Per allele

 

1.19

(0.91-1.56)

1.11

(0.83‒1.49)

 

1.07

(0.70-1.64)

1.21

(0.77-1.90)

6/4

1.27

(0.90-1.81)

1.14

(0.78-1.66)

rs2046210

GG

213/244

Ref.

 

Ref.

 

83/107

Ref.

 

Ref.

  

Ref.

 

Ref.

 

ESR1/6q25.1

AG

194/185

1.21

(0.92-1.59)

1.22

(0.90‒1.64)

78/72

1.41

(0.92-2.17)

1.63

(1.03-2.61)

130/137

1.11

(0.78-1.59)

0.99

(0.67-1.48)

 

AA

61/34

2.03

(1.29-3.25)

2.16

(1.32‒3.59)

27/14

2.46

(1.23-5.10)

2.93

(1.40-6.40)

116/113

1.69

(0.93-3.14)

1.69

(0.84-3.50)

 

Per allele

 

1.34

(1.10-1.63)

1.37

(1.11‒1.70)

 

1.49

(1.10-2.03)

1.70

(1.24-2.35)

34/20

1.23

(0.95-1.59)

1.14

(0.86-1.51)

rs909116

CC

166/178

Ref.

 

Ref.

 

71/64

Ref.

 

Ref.

  

Ref.

 

Ref.

 

LSP/11p15.5

CT

225/228

1.08

(0.81-1.43)

1.04

(0.77‒1.42)

88/106

0.76

(0.49-1.18)

0.90

(0.55-1.47)

95/114

1.36

(0.94-1.97)

1.20

(0.79-1.83)

 

TT

79/57

1.49

(0.99-2.24)

1.40

(0.90‒2.19)

30/23

1.21

(0.64-2.30)

1.23

(0.62-2.48)

137/122

1.72

(1.02-2.90)

1.69

(0.94-3.09)

 

Per allele

 

1.18

(0.97-1.42)

1.15

(0.93‒1.41)

 

0.98

(0.72-1.32)

1.11

(0.81-1.52)

49/34

1.32

(1.03-1.69)

1.24

(0.95-1.63)

rs30099

CC

225/216

Ref.

 

Ref.

 

93/84

Ref.

 

Ref.

  

Ref.

 

Ref.

 

/5q

TC

205/198

0.82

(0.52-1.29)

1.08

(0.80‒1.45)

82/84

0.87

(0.57-1.33)

0.96

(0.61-1.53)

132/132

1.08

(0.76-1.54)

1.21

(0.80-1.83)

 

TT

42/50

0.99

(0.76-1.30)

0.86

(0.52‒1.41)

15/25

0.53

(0.26-1.06)

0.51

(0.24-1.08)

123/114

1.12

(0.61-2.06)

1.19

(0.58-2.45)

 

Per allele

 

0.93

(0.76-1.13)

0.98

(0.79‒1.22)

 

0.78

(0.57-1.06)

0.85

(0.92-1.16)

27/25

1.04

(0.81-1.36)

1.12

(0.83-1.50)

rs2981282

CC

220/226

Ref.

 

Ref.

 

86/94

Ref.

 

Ref.

  

Ref.

 

Ref.

 

FGFR2 /10q26

TC

210/190

1.15

(0.87-1.50)

1.19

(0.89‒1.60)

91/81

1.23

(0.81-1.87)

1.48

(0.94-2.35)

134/132

1.10

(0.77-1.58)

1.08

(0.72-1.62)

 

TT

41/45

0.92

(0.58-1.47)

0.84

(0.50‒1.40)

13/17

0.89

(0.41-1.92)

1.07

(0.46-2.50)

119/109

0.95

(0.53-1.71)

0.76

(0.38-1.48)

 

Per allele

 

1.03

(0.84-1.25)

1.02

(0.82‒1.27)

 

1.04

(0.75-1.43)

1.27

(0.91-1.78)

28/28

1.04

(0.80-1.34)

0.94

(0.71-1.24)

rs795399

TT

255/249

Ref.

 

Ref.

 

90/107

Ref.

 

Ref.

  

Ref.

 

Ref.

 

IGF1/12q23.2

CT

180/173

0.84

(0.51-1.36)

1.05

(0.78‒1.41)

82/65

1.49

(0.97-2.30)

1.56

(0.98-2.48)

165/142

0.80

(0.56-1.15)

0.78

(0.52-1.18)

 

CC

34/41

1.03

(0.78-1.35)

0.85

(0.49‒1.45)

15/20

0.86

(0.41-1.77)

1.04

(0.46-2.27)

98/108

0.87

(0.44-1.70)

0.93

(0.43-1.99)

 

Per allele

 

0.96

(0.79-1.18)

0.97

(0.78‒1.21)

 

1.13

(0.83-1.55)

1.25

(0.91-1.72)

19/21

0.87

(0.66-1.14)

0.88

(0.66-1.17)

rs3757318

GG

249/281

Ref.

 

Ref.

 

95/111

Ref.

 

Ref.

  

Ref.

 

Ref.

 

ESR1/6q25.1

AG

182/162

1.27

(0.97-1.67)

1.25

(0.93‒1.69)

76/72

1.25

(0.82-1.91)

1.22

(0.77-1.92)

154/170

1.27

(0.88-1.81)

1.20

(0.79-1.80)

 

AA

34/19

2.01

(1.13-3.68)

2.05

(1.09‒3.97)

14/8

2.02

(0.83-5.25)

1.90

(0.73-5.25)

106/90

1.96

(0.92-4.37)

2.14

(0.88-5.49)

 

Per allele

 

1.34

(1.08-1.66)

1.33

(1.05‒1.69)

 

1.30

(0.93-1.83)

1.34

(0.95-1.91)

20/11

1.32

(1.00-1.76)

1.27

(0.93-1.75)

  1. aAlleles on upper line are common alleles; bAdjusted for age; cMultivariate adjusted for age, BMI, smoking, meat intake, mushroom intake, green and yellow vegetable intake, coffee intake, green tea intake, leisure-time exercise and education. Significant dates are showed in boldface. OR, odds ratio; CI, confidence interval.
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