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Table 5 Risks of oral cavity cancer related to family history of cancer in first-degree relatives stratified by tobacco smoking and alcohol drinking

From: Family history of cancer, personal history of medical conditions and risk of oral cavity cancer in France: the ICARE study

  Any first-degree relative
  History of cancer (any site) History of head and neck cancer
  No Yes OR (95% CI) §No Yes OR (95% CI)
  Cases/controls Cases/controls   Cases/controls Cases/controls  
Smoking       
Never 19/563 27/559 1.1 (0.6-2.1) 35/994 6/51 2.4 (1.0-7.0)
Ever 231/1002 306/1030 1.3 (1.1-1.5) 427/1785 58/104 2.7 (1.8-3.4)
Drinking       
≤2 glasses/day 75/961 75/954 0.9 (0.6-1.4) 123/1704 11/88 1.9 (1.0-3.5)
>2 glasses/day 167/597 254/631 1.4 (1.0-1.8) 329/1066 52/67 2.6 (1.2-3.3)
Smoking & drinking      
NS & D ≤2 glasses/day 16/412 17/425 0.9 (0.4-1.9) 30/740 1/39 1.2 (0.3-4.7)
ES & D ≤2 glasses/day 59/548 58/526 0.9 (0.6-1.4) 93/962 10/47 1.6 (1.0-3.9)
NS & D >2 glasses/day 3/147 8/129 2.7 (0.6-11.6) 5/248 4/10 18.8 (2.9-119.8)
ES & D >2 glasses/day 164/449 246/499 1.4 (1.0-1.8) 324/815 48/57 2.1 (1.3-2.9)
  1. OR adjusted for age, gender, area of residence, education level, tobacco smoking (duration, quantity and status), alcohol drinking (quantity) and BMI two years before the interview.
  2. NS = never smoking; ES = ever smoking; D = drinking.
  3. Reference category: no history of cancer (any site) in first-degree relatives.
  4. §Reference category: no history of head and neck cancer in first-degree relatives.