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Table 3 Risks of oral cavity cancer associated with family history of cancer among first-degree relatives

From: Family history of cancer, personal history of medical conditions and risk of oral cavity cancer in France: the ICARE study

 

Cases N

Controls N

OR (95% CI)†, ‡

Family history of cancer (father)

   

All type of cancer

   

Never

430

2503

1 (reference)

Ever

185

796

1.3 (0.9-1.6)

Head and neck cancer

   

Never

576

3200

1 (reference)

Ever

39

99

1.5 (0.9-2.4)

Family history of cancer (mother)

   

All type of cancer

   

Never

543

2784

1 (reference)

Ever

97

603

0.9 (0.6-1.2)

Head and neck cancer

   

Never

633

3378

1 (reference)

Ever

7

9

5.2 (1.2-23.9)

Family history of cancer (brothers)

   

All type of cancer

   

Never

229

1218

1 (reference)

Ever

77

288

1.4 (0.9-2.1)

Head and neck cancer

   

Never

286

1467

1 (reference)

Ever

20

39

2.6 (1.2-5.8)

Family history of cancer (sisters)

   

All type of cancer

   

Never

190

1236

1 (reference)

Ever

72

309

1.4 (0.9-2.1)

Head and neck cancer

   

Never

251

1517

1 (reference)

Ever

11

28

1.7 (0.6-4.2)

Family history of cancer (any first-degree relative)

  

All type of cancer

   

Never

250

1567

1 (reference)

Ever

333

1595

1.2 (0.9-1.5)

1-2

329

1552

1.0 (0.8-1.3)

≥3

4

43

1.5 (1.0-2.1)

Head and neck cancer

   

Never

462

2784

1 (reference)

Ever

68

157

1.9 (1.2-2.8)

1-2

64

150

1.7 (1.1-2.6)

≥3

4

7

7.2 (1.3-40.1)

  1. OR adjusted for age, gender, area of residence, education level, tobacco smoking (duration, quantity and status), alcohol drinking (quantity) and BMI two years before the interview.
  2. OR adjusted, in addition to the variables of the first model, for the number of brothers, sisters or siblings, respectively.