Table 3 Cox proportional hazards regression analysis of 5-year distant disease-free survival according to St Gallen Molecular subtypes with luminal A as reference group
A. Univariable analysis | ||||||
|---|---|---|---|---|---|---|
Primary tumour | Lymph node metastases | |||||
FrequencyN(%) | HR (95% CI) | p-value | FrequencyN (%) | HR (95% CI) | p-value | |
luminal A | 45 (53) | 1.0 | 38 (45) | 1.0 | ||
luminal B | 17 (20) | 2.8 (0.94-8.4) | 0.064 | 23 (27) | 3.1(1.0-9.5) | 0.048 |
HER2-positive | 11 (13) | 4.5 (1.4-14) | 0.011 | 11 (13) | 7.3 (2.2-24) | 0.001 |
Triple negative | 12 (14) | 5.9 (2.1-17) | 0.001 | 13 (15) | 4.6 (1.4-15) | 0.011 |
B. Multivariable analysis | ||||||
Primary tumour 1 | Lymph node metastases 1 | |||||
Frequency N (%) | HR (95% CI) | p -value | Frequency N (%) | HR (95% CI) | p -value | |
luminal A | 45 (53) | 1.0 | 38 (45) | 1.0 | ||
luminal B | 17 (20) | 2.9 (0.96-8.8) | 0.059 | 23 (27) | 2.9 (0.92-9.0) | 0.070 |
HER2-positive | 11 (13) | 3.1 (0.94-10) | 0.063 | 11 (13) | 4.8 (1.3-17) | 0.016 |
Triple negative | 12 (14) | 4.6 (1.6-13) | 0.006 | 13 (15) | 3.9 (1.2-13) | 0.029 |