Table 5 *ORs for the associations between UGT2B15 and UGT2B17 SNPs and PC in African American and Caucasian men
| Â | African American | Caucasian | ||||
|---|---|---|---|---|---|---|
SNP # Allele | Cases n (%) | Controls n (%) | Adjusted OR (95% CI)* | Cases n (%) | Controls n (%) | Adjusted OR (95% CI)* |
UGT2B15 | Â | Â | Â | Â | Â | Â |
rs1580083 | Â | Â | Â | Â | Â | Â |
TT | 0 (0) | 1 (0.72) | Reference | 2 (2.30) | 4 (20.9) | Reference |
TA | 86 (58.90) | 94 (68.12) | --- | 64 (73.56) | 155 (77.11) | 1.22 (0.10-14.43) |
AA | 60 (41.10) | 43 (31.16) | --- | 21 (24.14) | 42 (1.99) | 1.36 (0.11-16.96) |
AA/TA | 146 (100.0) | 137 (99.27) | --- | 85 (97.70) | 159 (79.1) | 1.25 (0.11-14.73) |
Log additive | Â | Â | -- | Â | Â | 1.12 (0.58-2.17) |
rs1960773 | Â | Â | Â | Â | Â | Â |
TT | 0 (0) | 2 (1.45) | Reference | 1 (1.16) | 3 (23.38) | Reference |
GT | 82 (56.94) | 93 (67.39) | -- | 62 (72.09) | 151 (75.12) | -- |
GG | 62 (43.06) | 43 (31.16) | - | 23 (26.74) | 47 (1.49) | -- |
GG/GT | 144 (100.0) | 136 (98.55) | -- | 85 (98.83) | 198 (76.62) | -- |
Log additive | Â | Â | -- | Â | Â | -- |
rs9994887 | Â | Â | Â | Â | Â | Â |
AA | 16 (10.96) | 28 (20.44) | Reference | 22 (25.29) | 63 (31.50) | Reference |
AG | 65 (44.52) | 63 (45.99) | 1.92 (0.72-5.10) | 43 (49.43) | 93 (46.50) | 1.93 (0.90-4.14) |
GG | 65 (44.52) | 46 (33.58) | 2.96 (1.09-8.04) | 22 (25.29) | 44 (22.00) | 1.87 (0.77-4.54) |
GG/AG | 130 (89.04) | 109 (79.56) | 2.34 (0.93-5.88) | 65 (74.71) | 137 (68.50) | 1.91 (0.92-3.96) |
Log additive | Â | Â | 1.66 (1.05-2.63) | Â | Â | 1.35 (0.88-2.08) |
rs13112099 | Â | Â | Â | Â | Â | Â |
TT | 16 (10.96) | 28 (20.00) | Reference | 22 (25.29) | 63 (31.18) | Reference |
GT | 67 (45.89) | 68 (48.57) | 1.96 (0.74-5.20) | 43 (49.43) | 95 (47.03) | 1.88 (0.88-4.05) |
GG | 63 (43.15) | 44 (31.43) | 2.94 (1.07-8.05) | 22 (25.29) | 44 (21.78) | 1.87 (0.77-4.54) |
GG/GT | 130 (89.04) | 112 (80.00) | 2.34 (0.93-5.88) | 65 (74.71) | 139 (68.81) | 1.88 (0.91-3.91) |
Log additive | Â | Â | 1.66 (1.03-2.63) | Â | Â | 1.35 (0.88-2.08) |
rs7686914 | Â | Â | Â | Â | Â | Â |
TT | 16 (11.03) | 28 (20.14) | Reference | 22 (25.58) | 63 (31.50) | Reference |
CT | 67 (46.21) | 67 (48.20) | 2.00 (0.75-5.31) | 42 (48.84) | 93 (46.50) | 1.88 (0.87-4.05) |
CC | 62 (42.75) | 44 (31.65) | 2.94 (1.07-8.05) | 22 (25.58) | 44 (22.00) | 1.87 (0.77-4.54) |
CC/CT | 129 (88.96) | 111 (79.86) | 2.37 (0.94-5.96) | 64 (74.42) | 137 (68.50) | 1.88 (0.91-3.91) |
Log additive | Â | Â | 1.64 (1.03-2.63) | Â | Â | 1.35 (0.88-2.08 |
rs7696472 | Â | Â | Â | Â | Â | Â |
GG | 16 (10.96) | 29 (20.70) | Reference | 22 (25.29) | 63 (31.66) | Reference |
AG | 67 (45.89) | 67 (47.86) | 1.96 (0.74-5.20) | 43 (49.43) | 90 (45.23) | 2.01 (0.93-4.32) |
AA | 63 (43.15) | 44 (31.43) | 2.94 (1.07-8.05) | 22 (25.29) | 46 (23.12) | 1.77 (0.73-4.27) |
AA/AG | 130 (89.04) | 111 (79.28) | 2.34 (0.93-5.88) | 65 (74.71) | 136 (68.34) | 1.93 (0.93-4.04) |
Log additive | Â | Â | 1.64 (1.03-2.63) | Â | Â | 1.31 (0.86-2.00) |
rs4148269 | Â | Â | Â | Â | Â | Â |
CC | 9 (6.25) | 11 (7.86) | Reference | 34 (39.53) | 68 (34.00) | Reference |
CA | 34 (23.61) | 58 (41.43) | 0.73 (0.20-2.70) | 38 (44.19) | 102 (51.00) | 0.89 (0.46-1.73) |
AA | 101 (70.14) | 71 (50.71) | 2.34 (0.67-7.83) | 14 (16.28) | 30 (15.00) | 1.46 (0.57-3.77) |
AA/CA | 135 (93.75) | 129 (92.14) | 1.65 (0.51-5.34) | 52 (60.46) | 132 (66.00) | 0.99 (0.53-1.85) |
Log additive | Â | Â | 2.04 (1.19-3.44) | Â | Â | 1.12 (0.71-1.75) |
rs3100 | Â | Â | Â | Â | Â | Â |
TT | 18 (12.86) | 32 (23.02) | Reference | 36 (41.38) | 74 (36.63) | Reference |
TC | 31 (22.14) | 42 (30.22) | 1.57 (0.54-4.55) | 37 (42.53) | 98 (48.51) | 0.91 (0.47-1.72) |
CC | 91 (65.00) | 65 (46.76) | 3.36 (1.36-8.30) | 14 (16.09) | 30 (14.85) | 1.48 (0.58-3.78) |
CC/TC | 122 (87.14) | 107 (76.97) | 2.75 (1.15-6.58) | 51 (58.62) | 128 (63.36) | 1.00 (0.54-1.84) |
Log additive | Â | Â | 1.89 (1.22-2.94) | Â | Â | 1.12 (0.72-1.75) |
Cis acting on UGT2B expression | Â | Â | Â | Â | Â | Â |
rs2168047 | Â | Â | Â | Â | Â | Â |
AA | 42 (28.97) | 36 (26.09) | Reference | 11 (12.64) | 23 (11.50) | Reference |
GA | 69 (47.59) | 65 (47.10) | 0.83 (0.39-1.75) | 43 (49.43) | 104 (52.00) | 0.92 (0.35-2.42) |
GG | 34 (23.44) | 37 (26.81) | 0.91 (0.37-2.21) | 33 (37.94) | 73 (36.50) | 1.07 (0.39-2.93) |
GG/GA | 103 (71.03) | 102 (73.91) | 0.85 (0.42-1.72) | 76 (87.35) | 177 (88.50) | 0.98 (0.38-2.48) |
Log additive | Â | Â | 0.94 (0.61-1.47) | Â | Â | 1.07 (0.67-1.72) |
rs6822259 | Â | Â | Â | Â | Â | Â |
CC | 1 (0.69) | 4 (2.86) | Reference | 2 (2.30) | 8 (3.98) | Reference |
CT | 25 (17.24) | 38 (27.14) | 0.61 (0.03-10.56) | 33 (37.93) | 59 (29.35) | 1.60 (0.86-2.96) |
TT | 119 (82.07) | 98 (70.00) | 0.91 (0.05-14.99) | 52 (59.77) | 134 (66.67) | 0.70 (0.14-3.54) |
TT/CT | 144 (99.31) | 136 (97.14) | 0.83(0.05-13.61) | 85 (97.70) | 193 (96.01) | 1.47 (0.81-2.67) |
Log additive | Â | Â | 1.34 (0.68-2.77) | Â | Â | 1.23 (0.75-2.03) |
rs17147338 | Â | Â | Â | Â | Â | Â |
TT | 91 (62.33) | 100 (71.43) | Reference | 77 (88.51) | 0 (0) | Reference |
CT | 46 (31.51) | 35 (25.00) | 1.72 (0.84-3.54) | 9 (10.34) | 16 (7.96) | -- |
CC | 9 (6.16) | 5 (3.57) | 1.51 (0.23-9.88) | 1 (1.15) | 185 (92.04) | -- |
CC/CT | 55 (37.67) | 40 (28.57) | 1.70 (0.85-3.40) | 10 (11.49) | 16 (7.96) | -- |
Log additive | Â | Â | 1.53 (0.84-2.82) | Â | Â | -- |
UGT2B17 | Â | Â | Â | Â | Â | Â |
rs7435827 | Â | Â | Â | Â | Â | Â |
GG | 13 (9.35) | 13 (9.56) | Reference | 40 (50.00) | 93 (49.21) | Reference |
GA | 22 (15.83) | 27 (19.85) | 0.47 (0.12-1.92) | 21 (26.25) | 51 (26.98) | 0.78 (0.37-1.66) |
AA | 104 (74.82) | 96 (70.59) | 0.80 (0.24-2.68) | 19 (23.75) | 45 (23.81) | 0.86 (0.40-1.85) |
AA/GA | 126 (90.65) | 123 (90.44) | 0.72 (0.22-2.41) | 40 (50.00) | 96 (50.79) | 0.82 (0.44-1.52) |
Log additive | Â | Â | 1.08 (0.64-1.85) | Â | Â | 1.08 (0.75-1.59) |
rs7686008 | Â | Â | Â | Â | Â | Â |
AA | 83 (56.85) | 92 (66.19) | Reference | 84 (96.55) | 189 (93.56) | Reference |
AT | 32 (21.92) | 25 (17.99) | 1.65 (0.74-3.69) | 2 (2.3) | 7 (3.47) | 0.70 (0.13-3.71) |
TT | 31 (21.23) | 22 (15.83) | 1.51 (0.67-3.44) | 1 (1.15) | 6 (2.97) | 0.99 (0.10-10.04) |
TT/AT | 63 (43.15) | 47 (33.81) | 1.58 (0.83-3.01) | 3 (3.45) | 13 (6.44) | 0.78 ( 0.20-3.08) |
Log additive | Â | Â | 1.28 (0.86-1.90) | Â | Â | 0.88 (0.33-2.36) |
rs7671342 | Â | Â | Â | Â | Â | Â |
GG | 22 (15.07) | 23 (16.43) | Reference | 15 (17.44) | 33 (16.34) | Reference |
GA | 25 (17.12) | 35 (25.00) | 0.66 (0.24-1.88) | 21 (24.42) | 50 (24.75) | 1.06 (0.42-2.67) |
AA | 99 (67.81) | 82 (58.57) | 1.51 (0.63-3.64) | 50 (58.14) | 119 (58.91) | 1.15 (0.51-2.59) |
AA/GA | 124 (84.93) | 117 (83.57) | 1.21 (0.52-2.84) | 71 (82.55) | 169 (83.66) | 1.12 (0.51-2.46) |
Log additive | Â | Â | 1.36 (0.90-2.08) | Â | Â | 1.07 (0.73-1.59) |
rs59678213 | Â | Â | Â | Â | Â | Â |
CC | 10 (7.35) | 8 (5.97) | Reference | 32 (40.00) | 73 (40.11) | Reference |
TC | 19 (13.97) | 24 (17.91) | 0.45 (0.10-2.00) | 27 (33.75) | 50 (27.47) | 1.04 (0.49-2.20) |
TT | 107 (78.68) | 102 (76.12) | 0.65 (0.18-2.41) | 21 (26.25) | 59 (32.42) | 0.80 (0.37-1.71) |
TT/TC | 126 (92.65) | 126 (94.02) | 0.62 (0.17-2.24) | 48 (60.00) | 109 (59.89) | 0.91 (0.48-1.73) |
Log additive | Â | Â | 0.99 (0.64-1.69) | Â | Â | 1.11 (0.76-1.61) |