Skip to main content

Table 5 *ORs for the associations between UGT2B15 and UGT2B17 SNPs and PC in African American and Caucasian men

From: Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study

  African American Caucasian
SNP # Allele Cases n (%) Controls n (%) Adjusted OR (95% CI)* Cases n (%) Controls n (%) Adjusted OR (95% CI)*
UGT2B15       
rs1580083       
TT 0 (0) 1 (0.72) Reference 2 (2.30) 4 (20.9) Reference
TA 86 (58.90) 94 (68.12) --- 64 (73.56) 155 (77.11) 1.22 (0.10-14.43)
AA 60 (41.10) 43 (31.16) --- 21 (24.14) 42 (1.99) 1.36 (0.11-16.96)
AA/TA 146 (100.0) 137 (99.27) --- 85 (97.70) 159 (79.1) 1.25 (0.11-14.73)
Log additive    --    1.12 (0.58-2.17)
rs1960773       
TT 0 (0) 2 (1.45) Reference 1 (1.16) 3 (23.38) Reference
GT 82 (56.94) 93 (67.39) -- 62 (72.09) 151 (75.12) --
GG 62 (43.06) 43 (31.16) - 23 (26.74) 47 (1.49) --
GG/GT 144 (100.0) 136 (98.55) -- 85 (98.83) 198 (76.62) --
Log additive    --    --
rs9994887       
AA 16 (10.96) 28 (20.44) Reference 22 (25.29) 63 (31.50) Reference
AG 65 (44.52) 63 (45.99) 1.92 (0.72-5.10) 43 (49.43) 93 (46.50) 1.93 (0.90-4.14)
GG 65 (44.52) 46 (33.58) 2.96 (1.09-8.04) 22 (25.29) 44 (22.00) 1.87 (0.77-4.54)
GG/AG 130 (89.04) 109 (79.56) 2.34 (0.93-5.88) 65 (74.71) 137 (68.50) 1.91 (0.92-3.96)
Log additive    1.66 (1.05-2.63)    1.35 (0.88-2.08)
rs13112099       
TT 16 (10.96) 28 (20.00) Reference 22 (25.29) 63 (31.18) Reference
GT 67 (45.89) 68 (48.57) 1.96 (0.74-5.20) 43 (49.43) 95 (47.03) 1.88 (0.88-4.05)
GG 63 (43.15) 44 (31.43) 2.94 (1.07-8.05) 22 (25.29) 44 (21.78) 1.87 (0.77-4.54)
GG/GT 130 (89.04) 112 (80.00) 2.34 (0.93-5.88) 65 (74.71) 139 (68.81) 1.88 (0.91-3.91)
Log additive    1.66 (1.03-2.63)    1.35 (0.88-2.08)
rs7686914       
TT 16 (11.03) 28 (20.14) Reference 22 (25.58) 63 (31.50) Reference
CT 67 (46.21) 67 (48.20) 2.00 (0.75-5.31) 42 (48.84) 93 (46.50) 1.88 (0.87-4.05)
CC 62 (42.75) 44 (31.65) 2.94 (1.07-8.05) 22 (25.58) 44 (22.00) 1.87 (0.77-4.54)
CC/CT 129 (88.96) 111 (79.86) 2.37 (0.94-5.96) 64 (74.42) 137 (68.50) 1.88 (0.91-3.91)
Log additive    1.64 (1.03-2.63)    1.35 (0.88-2.08
rs7696472       
GG 16 (10.96) 29 (20.70) Reference 22 (25.29) 63 (31.66) Reference
AG 67 (45.89) 67 (47.86) 1.96 (0.74-5.20) 43 (49.43) 90 (45.23) 2.01 (0.93-4.32)
AA 63 (43.15) 44 (31.43) 2.94 (1.07-8.05) 22 (25.29) 46 (23.12) 1.77 (0.73-4.27)
AA/AG 130 (89.04) 111 (79.28) 2.34 (0.93-5.88) 65 (74.71) 136 (68.34) 1.93 (0.93-4.04)
Log additive    1.64 (1.03-2.63)    1.31 (0.86-2.00)
rs4148269       
CC 9 (6.25) 11 (7.86) Reference 34 (39.53) 68 (34.00) Reference
CA 34 (23.61) 58 (41.43) 0.73 (0.20-2.70) 38 (44.19) 102 (51.00) 0.89 (0.46-1.73)
AA 101 (70.14) 71 (50.71) 2.34 (0.67-7.83) 14 (16.28) 30 (15.00) 1.46 (0.57-3.77)
AA/CA 135 (93.75) 129 (92.14) 1.65 (0.51-5.34) 52 (60.46) 132 (66.00) 0.99 (0.53-1.85)
Log additive    2.04 (1.19-3.44)    1.12 (0.71-1.75)
rs3100       
TT 18 (12.86) 32 (23.02) Reference 36 (41.38) 74 (36.63) Reference
TC 31 (22.14) 42 (30.22) 1.57 (0.54-4.55) 37 (42.53) 98 (48.51) 0.91 (0.47-1.72)
CC 91 (65.00) 65 (46.76) 3.36 (1.36-8.30) 14 (16.09) 30 (14.85) 1.48 (0.58-3.78)
CC/TC 122 (87.14) 107 (76.97) 2.75 (1.15-6.58) 51 (58.62) 128 (63.36) 1.00 (0.54-1.84)
Log additive    1.89 (1.22-2.94)    1.12 (0.72-1.75)
Cis acting on UGT2B expression       
rs2168047       
AA 42 (28.97) 36 (26.09) Reference 11 (12.64) 23 (11.50) Reference
GA 69 (47.59) 65 (47.10) 0.83 (0.39-1.75) 43 (49.43) 104 (52.00) 0.92 (0.35-2.42)
GG 34 (23.44) 37 (26.81) 0.91 (0.37-2.21) 33 (37.94) 73 (36.50) 1.07 (0.39-2.93)
GG/GA 103 (71.03) 102 (73.91) 0.85 (0.42-1.72) 76 (87.35) 177 (88.50) 0.98 (0.38-2.48)
Log additive    0.94 (0.61-1.47)    1.07 (0.67-1.72)
rs6822259       
CC 1 (0.69) 4 (2.86) Reference 2 (2.30) 8 (3.98) Reference
CT 25 (17.24) 38 (27.14) 0.61 (0.03-10.56) 33 (37.93) 59 (29.35) 1.60 (0.86-2.96)
TT 119 (82.07) 98 (70.00) 0.91 (0.05-14.99) 52 (59.77) 134 (66.67) 0.70 (0.14-3.54)
TT/CT 144 (99.31) 136 (97.14) 0.83(0.05-13.61) 85 (97.70) 193 (96.01) 1.47 (0.81-2.67)
Log additive    1.34 (0.68-2.77)    1.23 (0.75-2.03)
rs17147338       
TT 91 (62.33) 100 (71.43) Reference 77 (88.51) 0 (0) Reference
CT 46 (31.51) 35 (25.00) 1.72 (0.84-3.54) 9 (10.34) 16 (7.96) --
CC 9 (6.16) 5 (3.57) 1.51 (0.23-9.88) 1 (1.15) 185 (92.04) --
CC/CT 55 (37.67) 40 (28.57) 1.70 (0.85-3.40) 10 (11.49) 16 (7.96) --
Log additive    1.53 (0.84-2.82)    --
UGT2B17       
rs7435827       
GG 13 (9.35) 13 (9.56) Reference 40 (50.00) 93 (49.21) Reference
GA 22 (15.83) 27 (19.85) 0.47 (0.12-1.92) 21 (26.25) 51 (26.98) 0.78 (0.37-1.66)
AA 104 (74.82) 96 (70.59) 0.80 (0.24-2.68) 19 (23.75) 45 (23.81) 0.86 (0.40-1.85)
AA/GA 126 (90.65) 123 (90.44) 0.72 (0.22-2.41) 40 (50.00) 96 (50.79) 0.82 (0.44-1.52)
Log additive    1.08 (0.64-1.85)    1.08 (0.75-1.59)
rs7686008       
AA 83 (56.85) 92 (66.19) Reference 84 (96.55) 189 (93.56) Reference
AT 32 (21.92) 25 (17.99) 1.65 (0.74-3.69) 2 (2.3) 7 (3.47) 0.70 (0.13-3.71)
TT 31 (21.23) 22 (15.83) 1.51 (0.67-3.44) 1 (1.15) 6 (2.97) 0.99 (0.10-10.04)
TT/AT 63 (43.15) 47 (33.81) 1.58 (0.83-3.01) 3 (3.45) 13 (6.44) 0.78 ( 0.20-3.08)
Log additive    1.28 (0.86-1.90)    0.88 (0.33-2.36)
rs7671342       
GG 22 (15.07) 23 (16.43) Reference 15 (17.44) 33 (16.34) Reference
GA 25 (17.12) 35 (25.00) 0.66 (0.24-1.88) 21 (24.42) 50 (24.75) 1.06 (0.42-2.67)
AA 99 (67.81) 82 (58.57) 1.51 (0.63-3.64) 50 (58.14) 119 (58.91) 1.15 (0.51-2.59)
AA/GA 124 (84.93) 117 (83.57) 1.21 (0.52-2.84) 71 (82.55) 169 (83.66) 1.12 (0.51-2.46)
Log additive    1.36 (0.90-2.08)    1.07 (0.73-1.59)
rs59678213       
CC 10 (7.35) 8 (5.97) Reference 32 (40.00) 73 (40.11) Reference
TC 19 (13.97) 24 (17.91) 0.45 (0.10-2.00) 27 (33.75) 50 (27.47) 1.04 (0.49-2.20)
TT 107 (78.68) 102 (76.12) 0.65 (0.18-2.41) 21 (26.25) 59 (32.42) 0.80 (0.37-1.71)
TT/TC 126 (92.65) 126 (94.02) 0.62 (0.17-2.24) 48 (60.00) 109 (59.89) 0.91 (0.48-1.73)
Log additive    0.99 (0.64-1.69)    1.11 (0.76-1.61)
  1. *Adjusted for age and BMI.