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Table 4 *ORs for the associations between UGT2B15 and UGT2B17 SNPs and PC in low grade and high grade PC cases

From: Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study

SNP # Allele Low gleason <8 n (%) Adjusted OR (95% CI) High gleason ≥8 n (%) Adjusted OR* (95% CI)
UGT2B15     
rs1580083     
TT 0 (0) Reference 2 (10.00) Reference
TA 139 (65.88) -- 10 (50.00) 0.20 (0.02-2.42)
AA 72 (34.12) -- 8 (40.00) 0.33 (0.02-4.36)
AA/TA 211 (100.0) -- 18 (90.00) 0.13 (0.02-0.74)
Log additive   --   3.20 (0.30-33.45)
rs1960773     
TT 0 (0) Reference 1 (5.26) Reference
GT 132 (63.16) -- 11 (57.89) --
GG 77 (36.84) -- 7 (36.84) --
GG/GT 209 (100.0) -- 18 (94.73) --
Log additive   --   --
rs9994887     
AA 32 (15.17) Reference 5 (25.00) Reference
AG 101 (47.87) 2.13 (1.13-4.00) 7 (35.00) 0.86 (0.19-3.80)
GG 78 (36.97) 2.53 (1.30-4.99) 8 (40.00) 1.27 (0.26-6.17)
GG/AG 179 (84.83) 2.27 (1.24-4.14) 15 (75.00) 1.00 (0.25-3.90)
Log additive   1.94 (1.06-3.53)   2.34 (1.22-4.49)
rs13112099     
TT 32 (15.16) Reference 5 (25.00) Reference
GT 103 (48.81) 2.12 (1.13-3.98) 7 (35.00) 0.84 (0.19-3.71)
GG 76 (36.01) 2.50 (1.26-4.93) 8 (40.00) 1.30 (0.26-6.28)
GG/GT 179 (84.83) 2.25 (1.23-4.10) 15 (75.00) 1.00 (0.25-3.87)
Log additive   1.93 (1.06-3.52)   2.31 (1.20-4.44)
rs7686914     
TT 32 (15.23) Reference 7 (36.83) Reference
CT 102 (48.57) 2.14 (1.14-4.02) 7 (36.84) 0.86 (0.19-3.78)
CC 76 (36.19) 2.50 (1.26-4.92) 5 (26.32) 1.30 (0.26-6.30)
CC/CT 178 (84.76) 2.25 (1.23-4.13) 12 (63.16) 1.00 (0.26-3.92)
Log additive   1.94 (1.06-3.54)   2.31 (1.20-4.44)
rs7696472     
AA 32 (15.17) Reference 8 (40.00) Reference
AG 103 (48.82) 2.20 (1.16-4.12) 7 (35.00) 0.86 (0.19-3.82)
GG 76 (36.02) 2.43 (1.23-4.81) 5 (25.00) 1.26 (0.26-6.11)
GG/AG 179 (84.83) 2.30 (1.25-4.16) 12 (60.00) 1.00 (0.26-3.92)
Log additive   1.99 (1.10-3.63)   2.26 (1.18-4.33)
rs4148269     
CC 38 (18.18) Reference 5 (26.32) Reference
CA 66 (31.58) 0.76 (0.42-1.40) 5 (26.32) 2.16 (0.23-20.26)
AA 105 (50.24) 1.70 (0.86-3.36) 9 (47.36) 13.55 (1.34-136.99)
AA/CA 171 (81.81) 1.00 (0.56-1.74) 14 (73.68) 3.94 (0.47-2.58)
Log additive   0.81 (0.45-1.47)   1.96 (1.01-3.82)
rs3100     
TT 46 (22.33) Reference 7 (36.84) Reference
TC 64 (31.07) 1.04 (0.60-1.83) 4 (21.05) 1.10 (0.17-6.86)
CC 96 (46.60) 1.96 (1.06-3.63) 8 (42.10) 8.22 (1.31-51.60)
CC/TC 160 (77.66) 1.34 (0.81-2.22) 12 (63.16) 2.42 (0.50-11.83)
Log additive   1.04 (0.60-1.81)   2.16 (1.18-3.95)
rs2168047     
AA 49 (23.22) Reference 3 (15.79) Reference
GA 99 (46.92) 0.78 (0.43-1.42) 12 (63.16) 2.61 (0.30-22.38)
GG 63 (29.86) 0.96 (0.50-1.84) 4 (21.05) 1.92 (0.18-20.07)
GG/GA 162 (76.77) 0.84 (0.48-1.48) 16 (84.21) 2.38 (0.30-19.86)
Log additive   0.85 (0.51-1.40)   1.01 (0.53-1.91)
rs6822259     
CC 3 (1.43) Reference 0 (0) Reference
CT 50 (23.81) 1.25 (0.30-5.10) 7 (35.00) --
TT 157 (74.76) 1.27 (0.32-5.03) 13 (65.00) --
TT/CT 207 (98.57) 1.26 (0.32-4.95) 20 (100.00) --
Log additive   1.11 (0.68-1.79)   --
rs17147338     
CC 154 (72.99) Reference 12 (60.00) Reference
CT 48 (22.75) 1.64 (0.92-2.93) 7 (35.00) 2.78 (0.65-11.96)
TT 9 (4.27) 1.92 (0.30-12.18) 1 (5.00) 12.86 (0.91-181.95)
TT/CT 57 (27.01) 1.67 (0.94-2.91) 8 (40.00) 3.41 (0.89-13.08)
Log additive   1.70 (1.00-3.01)   2.44 (0.42-12.17)
UGT2B17     
rs7435827     
GG 50 (25.00) Reference 3 (16.67) Reference
GA 38 (19.00) 0.67 (0.34-1.31) 4 (22.22) 0.73 (0.11-4.72)
AA 112 (56.00) 0.87 (0.46-1.63) 11 (61.11) 1.33 (0.26-6.84)
AA/GA 150 (75.00) 0.78 (0.44-1.37) 15 (83.33) 1.03 (0.23-4.65)
Log additive   0.67 (0.35-1.32)   0.90 (0.49-1.66)
rs7686008     
AA 154 (72.99) Reference 12 (60.00) Reference
AT 29 (13.74) 1.25 (0.61-2.58) 4 (20.00) 5.42 (1.05-27.96)
TT 28 (13.27) 1.30 (0.60-2.80) 4 (20.00) 5.05 (0.72-35.66)
TT/AT 57 (27.01) 1.27 (0.71-2.28) 8 (40.00) 5.30 (1.19-23.55)
Log additive   1.41 (0.70-2.84)   1.42 (0.67-3.01)
rs7671342     
GG 34 (16.19) Reference 3 (14.28) Reference
GA 43 (20.48) 0.89 (0.44-1.81) 4 (19.05) 0.61 (0.08-4.60)
AA 133 (63.33) 1.31 (0.71-2.41) 14 (66.67) 1.28 (0.26-6.35)
AA/GA 176 (83.81) 1.17 (0.64-2.11) 18 (85.71) 1.05 (0.22-5.04)
Log additive   0.86 (0.43-1.73)   1.30 (0.72-2.36)
rs59678213     
CC 40 (20.20) Reference 2 (11.76) Reference
TC 41 (20.71) 0.99 (0.54-1.81) 4 (23.53) 2.77 (0.27-28.17)
TT 117 (59.09) 0.76 (0.40-1.45) 11 (64.71) 3.60 (0.38-33.75)
TT/TC 158 (79.79) 0.76 (0.42-1.38) 15 (88.23) 3.21 (0.37-27.47)
Log additive   1.02 (0.56-1.82)   1.18 (0.63-2.21)
  1. *Adjusted for age, race and BMI.