Table 4 *ORs for the associations between UGT2B15 and UGT2B17 SNPs and PC in low grade and high grade PC cases
SNP # Allele | Low gleason <8 n (%) | Adjusted OR (95% CI) | High gleason ≥8 n (%) | Adjusted OR* (95% CI) |
|---|---|---|---|---|
UGT2B15 | Â | Â | Â | Â |
rs1580083 | Â | Â | Â | Â |
TT | 0 (0) | Reference | 2 (10.00) | Reference |
TA | 139 (65.88) | -- | 10 (50.00) | 0.20 (0.02-2.42) |
AA | 72 (34.12) | -- | 8 (40.00) | 0.33 (0.02-4.36) |
AA/TA | 211 (100.0) | -- | 18 (90.00) | 0.13 (0.02-0.74) |
Log additive | Â | -- | Â | 3.20 (0.30-33.45) |
rs1960773 | Â | Â | Â | Â |
TT | 0 (0) | Reference | 1 (5.26) | Reference |
GT | 132 (63.16) | -- | 11 (57.89) | -- |
GG | 77 (36.84) | -- | 7 (36.84) | -- |
GG/GT | 209 (100.0) | -- | 18 (94.73) | -- |
Log additive | Â | -- | Â | -- |
rs9994887 | Â | Â | Â | Â |
AA | 32 (15.17) | Reference | 5 (25.00) | Reference |
AG | 101 (47.87) | 2.13 (1.13-4.00) | 7 (35.00) | 0.86 (0.19-3.80) |
GG | 78 (36.97) | 2.53 (1.30-4.99) | 8 (40.00) | 1.27 (0.26-6.17) |
GG/AG | 179 (84.83) | 2.27 (1.24-4.14) | 15 (75.00) | 1.00 (0.25-3.90) |
Log additive | Â | 1.94 (1.06-3.53) | Â | 2.34 (1.22-4.49) |
rs13112099 | Â | Â | Â | Â |
TT | 32 (15.16) | Reference | 5 (25.00) | Reference |
GT | 103 (48.81) | 2.12 (1.13-3.98) | 7 (35.00) | 0.84 (0.19-3.71) |
GG | 76 (36.01) | 2.50 (1.26-4.93) | 8 (40.00) | 1.30 (0.26-6.28) |
GG/GT | 179 (84.83) | 2.25 (1.23-4.10) | 15 (75.00) | 1.00 (0.25-3.87) |
Log additive | Â | 1.93 (1.06-3.52) | Â | 2.31 (1.20-4.44) |
rs7686914 | Â | Â | Â | Â |
TT | 32 (15.23) | Reference | 7 (36.83) | Reference |
CT | 102 (48.57) | 2.14 (1.14-4.02) | 7 (36.84) | 0.86 (0.19-3.78) |
CC | 76 (36.19) | 2.50 (1.26-4.92) | 5 (26.32) | 1.30 (0.26-6.30) |
CC/CT | 178 (84.76) | 2.25 (1.23-4.13) | 12 (63.16) | 1.00 (0.26-3.92) |
Log additive | Â | 1.94 (1.06-3.54) | Â | 2.31 (1.20-4.44) |
rs7696472 | Â | Â | Â | Â |
AA | 32 (15.17) | Reference | 8 (40.00) | Reference |
AG | 103 (48.82) | 2.20 (1.16-4.12) | 7 (35.00) | 0.86 (0.19-3.82) |
GG | 76 (36.02) | 2.43 (1.23-4.81) | 5 (25.00) | 1.26 (0.26-6.11) |
GG/AG | 179 (84.83) | 2.30 (1.25-4.16) | 12 (60.00) | 1.00 (0.26-3.92) |
Log additive | Â | 1.99 (1.10-3.63) | Â | 2.26 (1.18-4.33) |
rs4148269 | Â | Â | Â | Â |
CC | 38 (18.18) | Reference | 5 (26.32) | Reference |
CA | 66 (31.58) | 0.76 (0.42-1.40) | 5 (26.32) | 2.16 (0.23-20.26) |
AA | 105 (50.24) | 1.70 (0.86-3.36) | 9 (47.36) | 13.55 (1.34-136.99) |
AA/CA | 171 (81.81) | 1.00 (0.56-1.74) | 14 (73.68) | 3.94 (0.47-2.58) |
Log additive | Â | 0.81 (0.45-1.47) | Â | 1.96 (1.01-3.82) |
rs3100 | Â | Â | Â | Â |
TT | 46 (22.33) | Reference | 7 (36.84) | Reference |
TC | 64 (31.07) | 1.04 (0.60-1.83) | 4 (21.05) | 1.10 (0.17-6.86) |
CC | 96 (46.60) | 1.96 (1.06-3.63) | 8 (42.10) | 8.22 (1.31-51.60) |
CC/TC | 160 (77.66) | 1.34 (0.81-2.22) | 12 (63.16) | 2.42 (0.50-11.83) |
Log additive | Â | 1.04 (0.60-1.81) | Â | 2.16 (1.18-3.95) |
rs2168047 | Â | Â | Â | Â |
AA | 49 (23.22) | Reference | 3 (15.79) | Reference |
GA | 99 (46.92) | 0.78 (0.43-1.42) | 12 (63.16) | 2.61 (0.30-22.38) |
GG | 63 (29.86) | 0.96 (0.50-1.84) | 4 (21.05) | 1.92 (0.18-20.07) |
GG/GA | 162 (76.77) | 0.84 (0.48-1.48) | 16 (84.21) | 2.38 (0.30-19.86) |
Log additive | Â | 0.85 (0.51-1.40) | Â | 1.01 (0.53-1.91) |
rs6822259 | Â | Â | Â | Â |
CC | 3 (1.43) | Reference | 0 (0) | Reference |
CT | 50 (23.81) | 1.25 (0.30-5.10) | 7 (35.00) | -- |
TT | 157 (74.76) | 1.27 (0.32-5.03) | 13 (65.00) | -- |
TT/CT | 207 (98.57) | 1.26 (0.32-4.95) | 20 (100.00) | -- |
Log additive | Â | 1.11 (0.68-1.79) | Â | -- |
rs17147338 | Â | Â | Â | Â |
CC | 154 (72.99) | Reference | 12 (60.00) | Reference |
CT | 48 (22.75) | 1.64 (0.92-2.93) | 7 (35.00) | 2.78 (0.65-11.96) |
TT | 9 (4.27) | 1.92 (0.30-12.18) | 1 (5.00) | 12.86 (0.91-181.95) |
TT/CT | 57 (27.01) | 1.67 (0.94-2.91) | 8 (40.00) | 3.41 (0.89-13.08) |
Log additive | Â | 1.70 (1.00-3.01) | Â | 2.44 (0.42-12.17) |
UGT2B17 | Â | Â | Â | Â |
rs7435827 | Â | Â | Â | Â |
GG | 50 (25.00) | Reference | 3 (16.67) | Reference |
GA | 38 (19.00) | 0.67 (0.34-1.31) | 4 (22.22) | 0.73 (0.11-4.72) |
AA | 112 (56.00) | 0.87 (0.46-1.63) | 11 (61.11) | 1.33 (0.26-6.84) |
AA/GA | 150 (75.00) | 0.78 (0.44-1.37) | 15 (83.33) | 1.03 (0.23-4.65) |
Log additive | Â | 0.67 (0.35-1.32) | Â | 0.90 (0.49-1.66) |
rs7686008 | Â | Â | Â | Â |
AA | 154 (72.99) | Reference | 12 (60.00) | Reference |
AT | 29 (13.74) | 1.25 (0.61-2.58) | 4 (20.00) | 5.42 (1.05-27.96) |
TT | 28 (13.27) | 1.30 (0.60-2.80) | 4 (20.00) | 5.05 (0.72-35.66) |
TT/AT | 57 (27.01) | 1.27 (0.71-2.28) | 8 (40.00) | 5.30 (1.19-23.55) |
Log additive | Â | 1.41 (0.70-2.84) | Â | 1.42 (0.67-3.01) |
rs7671342 | Â | Â | Â | Â |
GG | 34 (16.19) | Reference | 3 (14.28) | Reference |
GA | 43 (20.48) | 0.89 (0.44-1.81) | 4 (19.05) | 0.61 (0.08-4.60) |
AA | 133 (63.33) | 1.31 (0.71-2.41) | 14 (66.67) | 1.28 (0.26-6.35) |
AA/GA | 176 (83.81) | 1.17 (0.64-2.11) | 18 (85.71) | 1.05 (0.22-5.04) |
Log additive | Â | 0.86 (0.43-1.73) | Â | 1.30 (0.72-2.36) |
rs59678213 | Â | Â | Â | Â |
CC | 40 (20.20) | Reference | 2 (11.76) | Reference |
TC | 41 (20.71) | 0.99 (0.54-1.81) | 4 (23.53) | 2.77 (0.27-28.17) |
TT | 117 (59.09) | 0.76 (0.40-1.45) | 11 (64.71) | 3.60 (0.38-33.75) |
TT/TC | 158 (79.79) | 0.76 (0.42-1.38) | 15 (88.23) | 3.21 (0.37-27.47) |
Log additive | Â | 1.02 (0.56-1.82) | Â | 1.18 (0.63-2.21) |