Table 3 *ORs for the associations between UGT2B15 and UGT2B17 SNPs and PC
SNP # Allele | Cases n (%) | Controls n (%) | OR (95% CI)* |
|---|---|---|---|
UGT2B15 | Â | Â | Â |
rs1580083 | Â | Â | Â |
TT | 2 (0.86) | 5 (1.47) | Reference |
TA | 150 (64.38) | 249 (73.45) | 2.32 (0.23-23.81) |
AA | 81 (34.76) | 85 (25.07) | 3.24 (0.31-33.93) |
AA/TA | 231 (99.14) | 334 (98.52) | 2.54 (0.25-26.00) |
Log additive | Â | Â | 1.43 (0.91-2.26) |
rs1960773 | Â | Â | Â |
TT | 1 (0.43) | 5 (1.47) | Reference |
GT | 144 (62.61) | 244 (71.98) | -- |
GG | 85 (36.96) | 90 (26.55) | -- |
TT/GT | 229 (99.56) | 334 (98.52) | -- |
Log additive | Â | Â | -- |
rs9994887 | Â | Â | Â |
AA | 38 (16.31) | 91 (26.84) | Reference |
AG | 108 (46.35) | 158 (46.61) | 1.94 (1.06-3.53) |
GG | 87 (37.34) | 90 (26.55) | 2.38 (1.24-4.55) |
GG/AG | 195 (83.69) | 248 (73.15) | 2.10 (1.18-3.71) |
Log additive | Â | Â | 1.49 (1.09-2.04) |
rs13112099 | Â | Â | Â |
TT | 38 (16.31) | 91 (26.61) | Reference |
GT | 110 (47.21) | 163 (47.66) | 1.93 (1.06-3.52) |
GG | 85 (36.48) | 88 (25.73) | 2.35 (1.22-4.51) |
GG/GT | 195 (83.69) | 251 (73.39) | 2.07 (1.12-3.67) |
Log additive | Â | Â | 1.48 (1.08-2.03) |
rs7686914 | Â | Â | Â |
TT | 38 (16.45) | 91 (26.84) | Reference |
CT | 109 (47.19) | 160 (47.20) | 1.94 (1.06-3.55) |
CC | 84 (36.36) | 88 (25.96) | 2.34 (1.22-4.50) |
CC/CT | 193 (83.55) | 248 (73.81) | 2.10 (1.17-3.70) |
Log additive | Â | Â | 1.48 (1.08-2.03) |
rs7696472 | Â | Â | Â |
GG | 38 (16.31) | 92 (26.97) | Reference |
AG | 110 (47.21) | 157 (46.04) | 2.00 (1.10-3.63) |
AA | 85 (36.48) | 90 (26.39) | 2.30 (1.20-4.40) |
AA/AG | 195 (83.69) | 249 (73.02) | 2.10 (1.18-3.72) |
Log additive | Â | Â | 1.49 (1.06-2.00) |
rs4148269 | Â | Â | Â |
CC | 43 (18.45) | 79 (23.23) | Reference |
CA | 72 (30.90) | 160 (47.05) | 0.81 (0.45-1.46) |
AA | 115 (49.35) | 101 (29.70) | 1.98 (1.02-3.85) |
AA/CA | 190 (81.54) | 261 (76.76) | 1.10 (0.63-1.90) |
Log additive | Â | Â | 1.45 (1.03-2.03) |
rs3100 | Â | Â | Â |
TT | 54 (23.78) | 106 (31.08) | Reference |
TC | 68 (29.95) | 140 (41.05) | 1.04 (0.60-1.81) |
CC | 105 (46.25) | 95 (27.85) | 2.18 (1.19-3.99) |
CC/TC | 173 (76.21) | 235 (68.91) | 1.41 (0.86-2.31) |
Log additive | Â | Â | 1.46 (1.08-1.98) |
Cis acting on UGT2B expression | Â | Â | Â |
rs2168047 | Â | Â | Â |
AA | 53 (22.84) | 59 (17.45) | Reference |
GA | 112 (48.27) | 169 (50.00) | 0.86 (0.48-1.53) |
GG | 67 (28.87) | 110 (32.54) | 1.00 (0.52-1.88) |
GG/GA | 179 (77.15) | 279 (82.54) | 0.90 (0.52-1.57) |
Log additive | Â | Â | 1.01 (0.74-1.38) |
rs6822259 | Â | Â | Â |
CC | 3 (1.29) | 12 (3.52) | Reference |
CT | 58 (25.00) | 97 (28.44) | 1.48 (0.36-6.02) |
TT | 171 (73.70) | 232 (68.03) | 1.34 (0.34-5.31) |
TT/CT | 229 (98.70) | 329 (96.48) | 1.39 (0.35-5.43) |
Log additive | Â | Â | 1.02 (0.68-1.53) |
rs17147338 | Â | Â | Â |
CC | 168 (72.1) | 285 (83.58) | Reference |
CT | 55 (23.61) | 51 (14.96) | 1.68 (0.96-2.97) |
TT | 10 (4.29) | 5 (1.47) | 2.41 (0.42-13.94) |
TT/CT | 65 (27.9) | 56 (16.42) | 1.73 (1.00-3.00) |
Log additive | Â | Â | 1.65 (1.00-2.70) |
UGT2B17 | Â | Â | Â |
rs7435827 | Â | Â | Â |
GG | 53 (24.20) | 106 (32.61) | Reference |
GA | 43 (19.63) | 78 (24.00) | 0.67 (0.35-1.30) |
AA | 123 (56.16) | 141 (43.38) | 0.90 (0.49-1.66) |
AA/GA | 166 (75.79) | 219 (67.38) | 0.80 (0.46-1.38) |
Log additive | Â | Â | 0.97 (0.71-1.36) |
rs7686008 | Â | Â | Â |
AA | 168 (71.79) | 281 (82.4) | Reference |
AT | 34 (14.53) | 32 (9.38) | 1.40 (0.69-2.79) |
TT | 32 (13.68) | 28 (8.21) | 1.40 (0.66-2.96) |
TT/AT | 66 (28.21) | 60 (17.6) | 1.39 (0.79-2.44) |
Log additive | Â | Â | 1.21 (0.85-1.73) |
rs7671342 | Â | Â | Â |
GG | 37 (15.94) | 56 (16.37) | Reference |
GA | 46 (19.83) | 85 (24.85) | 0.86 (0.43-1.73) |
AA | 149 (64.22) | 201 (58.77) | 1.32 (0.73-2.40) |
AA/GA | 195 (84.05) | 286 (83.62) | 1.17 (0.65-2.08) |
Log additive | Â | Â | 1.21 (0.91-1.61) |
rs59678213 | Â | Â | Â |
CC | 42 (19.44) | 81 (25.63) | Reference |
TC | 46 (21.29) | 74 (23.42) | 0.84 (0.43-1.63) |
TT | 128 (59.26) | 161 (50.94) | 0.85 (0.45-1.59) |
TT/TC | 174 (80.55) | 235 (74.37) | 0.84 (0.47-1.50) |
Log additive | Â | Â | 0.92 (0.68-1.26) |