Figure 4

Gene networks generated by Ingenuity Pathway Analysis of 204 differentially expressed genes. a. Highest scoring signalling network 1 showing the IGF1, PI3K/Akt, NFkB and ERK signalling axes. Molecular relationships with genes from the current study (highlighted in green/red), as well as from the IPA knowledge base, are shown. Green indicates over-expressed whereas red indicates under-expressed genes. Other signalling pathways such as E2f, Vegf and estrogen receptor are also seen. Associated functions include cellular development, cellular growth and proliferation, and cell cycle. b. Signalling network 2 showing the MYC and RB1 signalling axis. Molecular relationships with genes from the current study (highlighted in green/red), as well as from the IPA knowledge base, are shown. Associated functions include cell cycle, connective tissue development and function, cell death and survival. c. Signalling network 3 showing the TP53 and CCND1 signalling axis. Associated functions include cell morphology, cellular assembly and organization, and cellular development. d. Signalling network 4 showing the IGF1R, MAPK8 and TP53 complex signalling axes. Associated functions include cell cycle, cell death and survival, and cellular development. e. Signalling network 5 showing the TNF and SREBF1 complex signalling pathways. Associated functions include lipid metabolism, molecular transport, and small molecule biochemistry.